This federal Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), will provide $1,867,823 to the Childrens Hospital Medical Center in Cincinnati, Ohio to study the genomic and developmental mechanisms underlying frontonasal dysplasia, a congenital craniofacial disorder. The project aims to investigate how structural variations, such as deletions and duplications, can disrupt the...
This federal Project Grant award, valued at $294,000 and spanning September 2024 to September 2026, was provided by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research (CFDA 93.121) program. The grant supports research to understand the mechanisms of craniofacial cartilage differentiation from human neural crest stem cells, with the goal of developing tissue engineering approaches to repair birth defects and injuries to the head and...
The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $521,209.45 Project Grant (CFDA 93.121 - Oral Diseases and Disorders Research) to The Research Foundation For The State University Of New York (RF SUNY) to conduct research on the role of the transcriptional repressor ZEB2 in human neural crest cell formation and craniofacial pathology. The project aims to delineate ZEB2's function in regulating TGF-beta signaling during neural crest cell development and how...
This National Institute of Dental and Craniofacial Research (NIDCR) Project Grant award under the Oral Diseases and Disorders Research program (CFDA 93.121) provides $320,053 to the University of Southern California (USC) to conduct comprehensive research on the craniofacial skeleton and connective tissue development. The 8-year project will utilize advanced techniques in spatial transcriptomics and mouse genetics to identify genes and pathways regulating the assembly of the craniofacial...
This Project Grant award of $889,616.00 from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), supports research on RNA localization in neural crest migratory protrusions. The goal is to understand the cellular and molecular mechanisms by which specific RNAs and proteins enriched in neural crest cell (NCC) projections promote NCC migration, which is critical for normal development and addressing related birth...
The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $178,848 five-year Project Grant (CFDA 93.121 - Oral Diseases and Disorders Research) to The Regents of the University of California, San Francisco (UCSF) to study the role of the p120-catenin protein in craniofacial development and disease. The project aims to elucidate the molecular mechanisms underlying cleft lip formation, leveraging newly developed mouse models and live imaging approaches to understand how...
This federal Project Grant award, totaling $619,304.36 and issued by the National Institute of Dental and Craniofacial Research (NIDCR), supports research under the Oral Diseases and Disorders Research program (CFDA 93.121). The award aims to develop and apply tools to precisely modulate the dosage of transcription factors involved in craniofacial development, particularly focusing on the transcription factor SOX9. The research seeks to understand the rules governing which regulatory elements...
The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $452,681 Project Grant under the Oral Diseases and Disorders Research program (CFDA 93.121) to The Regents of the University of California, San Francisco (UCSF) for the project "Control of Mammalian Craniofacial Morphogenesis by the ESCRT Machinery". The research aims to determine the tissue-specific roles of the ESCRT machinery in regulating signaling pathways and lipid metabolism during mammalian...
The National Institute of Dental and Craniofacial Research (NIDCR) has awarded a $148,176 Project Grant under the Oral Diseases and Disorders Research program (CFDA 93.121) to The Regents of the University of California, Berkeley. The funding will support research to uncover novel gene regulatory networks underlying craniofacial development and specialization in pupfish species. The project aims to leverage the unique evolutionary model of Cyprinodon pupfishes on San Salvador Island to...
This federal Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), is funding research to investigate the role of SOX transcription factors in the specialization of neural crest cells and the underlying causes of craniofacial disorders. The $821,236.30 award, which runs from September 16, 2024 to August 31, 2027, will be conducted by the University of Kentucky Research Foundation. The...
This Project Grant award for $493,458, provided by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121), supports research to investigate the cellular and molecular mechanisms that govern cranial neural crest cell (CNCC) development and differentiation. The key objectives are to determine how the ARID1A and ARID1B chromatin remodeling proteins regulate CNCC multipotency, epithelial-to-mesenchymal transition, and migration, as well as how they interact with transcription factors like GLI3 to integrate developmental signaling pathways like Hedgehog and Wnt. The award will fund 5 years of research at the Children's Hospital Medical Center in Cincinnati, Ohio, to advance the understanding of CNCC biology and its implications for craniofacial development.