Project Grant R01AG099338
- The National Institute on Aging, part of the Department of Health and Human Services National Institutes of Health, awarded $1.373 million to the University of California, Davis on May 15, 2026 under the Aging Research program (CFDA 93.866) to investigate skeletal stem cell-based cartilage regeneration in aged and osteoarthritic joints. The recipient will elucidate cellular dynamics and molecular mechanisms underlying skeletal stem cell (SSC)-mediated cartilage repair, with particular focus on...
- The National Institute on Aging awarded Duke University $444,125 under the Aging Research program (CFDA 93.866) on August 15, 2026, to investigate B cell rejuvenation as a mechanism to improve bone fracture healing in aged populations. The project will test whether maresin 1 treatment of B cells isolated from aged mice can restore interleukin-7 receptor (IL7R) expression, enhance anti-inflammatory cytokine secretion, and improve fracture healing outcomes when injected at fracture sites. The...
- The National Institute on Aging awarded The Trustees of the University of Pennsylvania $723,105 on May 15, 2026, under the Aging Research program (CFDA 93.866) to investigate activin A signaling pathways in bone repair mechanisms. The work targets delayed and nonunion fractures, which occur in 5–10% of fractures and pose substantial morbidity and quality-of-life impacts, particularly in aging populations where geriatric fractures are rising in prevalence. The recipient will conduct research on...
- The National Institute on Aging awarded The Washington University $518,372 on May 1, 2026, under the Aging Research program (CFDA 93.866) to investigate bone marrow adipocyte regulation of skeletal health and neural control of bone remodeling. The research defines neuro-adipose-bone crosstalk within the skeletal niche to develop strategies supporting bone health and preventing age- and disease-associated bone loss. Specific aims include establishing mechanisms of bone marrow adipocyte-mediated...
- The National Institute on Aging awarded University of Massachusetts Medical School $626,409 on February 1, 2026, under the Aging Research program (CFDA 93.866) to investigate how aging impairs wound healing through hematopoietic stem cell dysfunction. The research uses single-cell epigenomics to characterize how aging affects gene expression of individual immune cells and the epigenetic modifications that regulate that expression. The project addresses whether aging impairs cutaneous wound...
- The National Institute on Aging, part of the Department of Health and Human Services, awarded $533,500 to the Buck Institute for Research on Aging on July 15, 2026, under the Aging Research program (CFDA 93.866). The award funds examination of the role of autonomic innervation in muscle stem cell aging. The research investigates the functional link between autonomic nervous system neurons and muscle stem cells using Drosophila melanogaster as a model organism. The project will refine...
- The National Institute on Aging awarded The Medical College of Wisconsin, Inc. $618,354 on September 1, 2026, under the Aging Research program (CFDA 93.866) to investigate endothelial cell senescence in tissue regeneration and repair. The award is a Project Grant (R01AG095980) with performance through May 31, 2031. The research examines how aging impairs angiogenesis—the formation of new blood capillaries—and how endothelial cell senescence contributes to deficiencies in organ regeneration and...
- The National Institute on Aging awarded Baylor College of Medicine $430,212 under the Aging Research program (CFDA 93.866) on September 1, 2026, for an exploratory R21 project to establish Procotyla fluviatilis, a North American planarian species, as a comparative model for aging research. The funded work will define how stem cell function and tissue structure change across the flatworm's seasonal life cycle, map age-associated cellular and transcriptional changes using single-cell sequencing,...
- The National Institute on Aging awarded the University of Arkansas for Medical Sciences $487,847 under the Aging Research program (CFDA 93.866) on June 1, 2026, to investigate the role of autophagy in skeletal diseases, specifically aging-related bone loss and osteogenesis imperfecta. The research examines how macroautophagy—a cellular recycling process facilitating lysosomal degradation of damaged proteins and organelles—affects bone formation in osteoblast lineage cells. The recipient will...
- The National Institute on Aging awarded the University of California, Berkeley $598,837 on August 15, 2026, under the Aging Research program (CFDA 93.866) to investigate how hematopoietic stem cell aging affects distant tissues and organismal aging. The research will characterize a mouse model that reverses hematopoietic stem cell (HSC) aging by measuring changes in healthspan and lifespan and deciphering the molecular and cellular mechanisms underlying those alterations. The work tests the...
The National Institute on Aging awarded Baylor College of Medicine $651,838 under the Aging Research program (CFDA 93.866) on September 1, 2026, to define the regulatory mechanisms of periosteal skeletal stem cells (P-SSCs) in bone maintenance and repair with aging. The research addresses the clinical problem that bone healing capacity declines with age, creating significant healthcare burden from delayed healing and non-union in aged bone defects. The project will characterize the in vivo niche regulatory mechanisms that suppress P-SSC activity in adult and aged bones, building on preliminary findings that the gene LRP1 and marker CD13 distinguish P-SSCs and that LRP1 expression decreases markedly in aged bone. The work aims to develop novel approaches to activate P-SSC function to improve bone healing outcomes in aged bone injuries. Place of performance is Houston, Texas. The award runs through August 31, 2031.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $651.8k | 8/26/26 |