Project Grant R01AG095155
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded a $146,070 Project Grant to the University of Texas at Austin, effective September 1, 2025, through May 31, 2030, under the Aging Research program (CFDA 93.866). This award supports research investigating how the accumulation of senescent cells and their secretory phenotypes impact osteocyte mechanobiology—the ability of bone cells to sense and respond to mechanical stimuli. The project will develop novel...
- Federal Grant Award Summary The University of California, San Francisco received a $1,381,726 Project Grant from the National Institute on Aging (Aging Research program, CFDA 93.866) awarded August 1, 2025, with completion scheduled for May 31, 2030. This research initiative, titled "Triangulating Mechanisms of Microbiome-Joint Crosstalk," investigates the interorgan communication between the gut microbiome and joints in osteoarthritis (OA) pathogenesis. The project addresses a...
- Federal Grant Award Summary The National Institute on Aging (NIA), under the Aging Research program (CFDA 93.866), awarded The Washington University a project grant of $518,372 effective May 1, 2026, through January 31, 2031. This research project investigates the regulatory mechanisms and functional roles of bone marrow adipose tissue (BMAT) and bone marrow adipocytes (BMADs) in skeletal health and neural regulation of bone. The primary deliverables include scientific research characterizing...
- Federal Grant Award Summary The University of Pennsylvania received a $164,190 Project Grant award from the National Institute on Aging under the Aging Research program (CFDA 93.866), effective November 27, 2025, with a completion date of May 31, 2030. The research project, titled "Modulating Synovial Mechanobiology to Mitigate Disease Progression in Osteoarthritis," will be conducted at the institution's Philadelphia, Pennsylvania facility. This award supports biomedical research...
- Federal Grant Award Summary The National Institute on Aging awarded a $708,137 Project Grant to New York University School of Medicine (Award Date: February 1, 2026; Completion Date: January 31, 2030) under the Aging Research program (CFDA 93.866) to develop and validate advanced technologies for probing the biophysical properties of aging cells. The project focuses on creating Genetically Encoded Multimeric Particles (GEMs)—self-assembling, genetically encoded probe particles that enable...
- Federal Grant Award Summary The University of California, San Diego received a $700,795 Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866) for the period of February 1, 2026, through January 31, 2031. The award funds the development and deployment of REDCAT (Raman Enhanced Determination of Cell Atlas and Typing), an integrated research platform designed to map single-cell metabolic activity in complex tissues and identify transcriptional and...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded The Salk Institute for Biological Studies a Project Grant of $620,441 under the Aging Research program (CFDA 93.866), with an award date of February 15, 2026 and ultimate completion date of January 31, 2031. This research initiative focuses on characterizing activity-dependent changes to neuronal populations in the spinal dorsal horn during aging and determining the functional consequences of dorsal horn remodeling for...
- Federal Project Grant Award Summary The University of Pittsburgh received a $428,123 Project Grant from the National Institute on Aging (Aging Research program, CFDA 93.866) with an award date of February 1, 2026, and completion date of January 31, 2028. The grant funds research to identify and validate molecular targets for enhancing the regenerative capacity of aging chondrocytes and improving cartilage resilience. The research builds on preliminary findings identifying GATA Binding Protein...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded The Regents of the University of California, San Francisco $460,283 through the Aging Research program (CFDA 93.866) to conduct a two-year research project from September 1, 2025 through August 31, 2027. This Project Grant supports biomedical research directed toward understanding the aging process and age-related diseases, with the funded research examining the role of reverse electron transport (RET) inhibition in...
- Federal Grant Award Summary The National Institute on Aging (CFDA 93.866, Aging Research program) awarded University of California, Berkeley a $2.32 million Project Grant effective August 1, 2025, through July 31, 2027, to develop magnetogenetic techniques for studying Alzheimer's disease (AD) pathogenesis. The project will create cell-type-specific tools to manipulate vulnerable brain neurons and astrocytes implicated in tau protein accumulation and spread. The research employs FERIC...
The National Institute on Aging (part of the National Institutes of Health) awarded a Project Grant of $627,212 to the University of California, Davis under the Aging Research program (CFDA 93.866) on May 15, 2026, with a completion date of January 31, 2031. This award supports biomedical research directed toward understanding and treating age-related diseases, specifically osteoarthritis (OA). The research focuses on developing and validating stem cell-based cartilage regeneration therapies to address the progressive destruction of hyaline cartilage that occurs in aging and osteoarthritic joints. The grant funds investigation into Growth-Factor Enhanced Microfracture (GEM), a therapeutic approach that activates tissue-resident skeletal stem cells to regenerate full-thickness cartilage defects. The research team will elucidate the cellular dynamics and molecular mechanisms underlying stem cell-mediated cartilage repair, with particular emphasis on understanding why GEM is less effective in aged populations and how blocking Fibroblast Growth Factor 7 (FGF7) signaling can restore cartilage formation in aged and osteoarthritic joint environments. The outcomes of this research are intended to develop practical strategies for applying GEM in settings with compromised cellular microenvironments, potentially advancing treatment options for degenerative joint disease in older populations.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $627.2k | 5/4/26 |