Project Grant R01AG095980
- The National Institute on Aging awarded University of Massachusetts Medical School $626,409 on February 1, 2026, under the Aging Research program (CFDA 93.866) to investigate how aging impairs wound healing through hematopoietic stem cell dysfunction. The research uses single-cell epigenomics to characterize how aging affects gene expression of individual immune cells and the epigenetic modifications that regulate that expression. The project addresses whether aging impairs cutaneous wound...
- The National Institute on Aging awarded Vanderbilt University Medical Center $3,079,819 for a Project Grant (R01AG092663) on January 1, 2026, under the Aging Research program (CFDA 93.866). The award funds research probing mechanistic links between endothelial aging and dementia. The recipient will passage human induced pluripotent stem cells differentiated to endothelial cells (hiPSC-ECs) obtained from healthy adults and individuals with vascular contributions to cognitive impairment and...
- The National Institute on Aging awarded Cleveland Clinic Lerner College of Medicine of Case Western Reserve University $659,309 on December 15, 2025, under the Aging Research program (CFDA 93.866) to investigate endothelial toll-like receptor 2 and 4 signaling in sex dimorphism of pathological angiogenesis and aging. The research examines molecular mechanisms underlying sex-dependent differences in endothelial cell function that may influence outcomes of angiogenesis-driven diseases and aging....
- The National Institute on Aging awarded Baylor College of Medicine $651,838 under the Aging Research program (CFDA 93.866) on September 1, 2026, to define the regulatory mechanisms of periosteal skeletal stem cells (P-SSCs) in bone maintenance and repair with aging. The research addresses the clinical problem that bone healing capacity declines with age, creating significant healthcare burden from delayed healing and non-union in aged bone defects. The project will characterize the in vivo niche...
- The National Institute on Aging awarded The College of Wooster $482,620 on April 15, 2026, under the Aging Research program (CFDA 93.866) to build and experimentally validate single-cell regulatory network models that reproduce environment-dependent commitment of epithelial cells to senescence, hybrid epithelial-to-mesenchymal transition (E/M), and mesenchymal states as a function of age. The project addresses how aging disrupts wound healing in epithelial sheets and spouting angiogenesis by...
- The National Institute on Aging awarded Albany Medical College $246,000 on September 1, 2026, under the Aging Research program (CFDA 93.866) to investigate inter-organelle dynamics during aging in eukaryotic cells. The work will characterize spatial contexts of inter-organelle communication using C. elegans as a model system to identify organellar signatures that develop during aging and proteostasis decline, establishing a platform to understand how aging impacts organelle interactions and...
- The National Institute on Aging awarded Tufts Medical Center Parent, Inc. (doing business as Tufts Medical Center) $357,000 under the Aging Research program (CFDA 93.866) on September 1, 2026, to investigate endothelial pannexin1-induced inflammation in Alzheimer's disease. The research tests the hypothesis that amyloid-beta upregulates cerebral endothelial pannexin1 expression, which promotes vascular dysfunction and Alzheimer's disease progression through increased neuroinflammation and...
- The National Institute on Aging, part of the Department of Health and Human Services, awarded Old Dominion University $160,000 on September 1, 2026, to develop and test a three-dimensional bioprinted mammary model system for investigating age-related cellular dysfunction and regenerative microenvironment mechanisms under the Aging Research program (CFDA 93.866). The project addresses molecular mechanisms underlying cellular and tissue rejuvenation through a regenerative microenvironment model....
- The National Institute on Aging awarded Yale University $461,311 under the Aging Research program (CFDA 93.866) on May 1, 2026, to investigate vascular smooth muscle cell aging and epigenetic reprogramming as a pathway to reducing cardiovascular disease risk. The research examines how smooth muscle cells in arterial walls undergo epigenetic alterations—particularly DNA methylation changes—that drive vascular stiffening and atherosclerosis in aging. Yale's team has developed smooth muscle...
- The National Institute on Aging awarded Beth Israel Deaconess Medical Center, Inc. $518,555 on September 1, 2026, under the Aging Research program (CFDA 93.866) to develop spatially validated human lymphoid follicles-on-chip for modeling inflammaging and age-related immune dysfunction. The recipient will establish a lymphoid follicle organ-on-chip platform that recapitulates key hallmarks of human lymphoid function, including germinal center formation, AID expression, and antiviral antibody...
The National Institute on Aging awarded The Medical College of Wisconsin, Inc. $618,354 on September 1, 2026, under the Aging Research program (CFDA 93.866) to investigate endothelial cell senescence in tissue regeneration and repair. The award is a Project Grant (R01AG095980) with performance through May 31, 2031. The research examines how aging impairs angiogenesis—the formation of new blood capillaries—and how endothelial cell senescence contributes to deficiencies in organ regeneration and repair. The work uses mouse skin wound models, unilateral pneumonectomy models, and human endothelial cell organoid systems to determine the role of endothelial cell senescence in angiogenesis during tissue regeneration and repair in young versus aged tissues. The investigation focuses on the roles of the Wnt receptor low-density lipoprotein receptor-related protein 5 (LRP5) and the adipokine adiponectin in regulating angiogenesis and cellular senescence. Performance occurs at The Medical College of Wisconsin's location in Wauwatosa, Wisconsin.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $618.4k | 8/21/26 |