Project Grant R01AG094715
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded a $146,070 Project Grant to the University of Texas at Austin, effective September 1, 2025, through May 31, 2030, under the Aging Research program (CFDA 93.866). This award supports research investigating how the accumulation of senescent cells and their secretory phenotypes impact osteocyte mechanobiology—the ability of bone cells to sense and respond to mechanical stimuli. The project will develop novel...
- Federal Grant Award Summary The National Institute on Aging (NIA), under the Aging Research program (CFDA 93.866), awarded the University of Virginia a Project Grant of $1,044,334 effective August 1, 2025, through May 31, 2030. This research award supports investigation into the mechanisms of ribosomal DNA (rDNA) instability during aging, with the goal of understanding how genomic instability—a hallmark of aging conserved across species—contributes to cellular aging processes. The project will...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded Indiana University Indianapolis $3,126,515 on August 15, 2025, under the Aging Research program (CFDA 93.866) to support research investigating a novel inter-tissue L-BAIBA/FGF23 (L-beta-aminoisobutyric acid/fibroblast growth factor 23) signaling axis as a therapeutic target for enhancing musculoskeletal remodeling in aging populations. The research project, with a completion date of May 31, 2029, will generate...
- Federal Grant Award Summary The National Institute on Aging awarded a $627,212 Project Grant to the University of California, Davis effective May 15, 2026, through January 31, 2031, under the Aging Research program (CFDA 93.866). This award funds research focused on skeletal stem cell (SSC)-based cartilage regeneration strategies to address osteoarthritis in aged and diseased joint microenvironments. The research builds upon the institution's prior development of Growth-Factor Enhanced...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded the University of Pennsylvania $723,105 under the Aging Research program (CFDA 93.866) to conduct research targeting Activin A signaling to enhance bone repair. The project, which commenced May 15, 2026 and concludes February 28, 2031, focuses on addressing delayed and nonunion fractures that affect 5-10% of patients and represent a significant clinical problem, particularly among aging populations. The research...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded The Washington University a $518,372 Project Grant effective May 1, 2026, through January 31, 2031, under the Aging Research program (CFDA 93.866). This research project will investigate the mechanisms by which bone marrow adipocytes (BMADs) regulate bone health and protect against age- and disease-associated bone loss. The research will produce scientific knowledge regarding neuro-adipose-bone crosstalk within the...
- Federal Grant Award Summary Vanderbilt University Medical Center received a $149,889 Project Grant from the National Institute on Aging under the Aging Research program (CFDA 93.866) beginning September 1, 2025, with a completion date of May 31, 2030. The award supports a discovery-focused research initiative to identify mechanistic associations between epigenetic bone age, frailty measures, and bone imaging findings using artificial intelligence (AI) and deep learning (DL) approaches. The...
- Federal Grant Award Summary The Buck Institute for Research on Aging received a $809,486 Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), awarded February 1, 2026, with completion scheduled for January 31, 2031. This award supports biomedical research investigating the role of oxidation resistance 1 (OXR1) and retromer proteins in brain aging and Alzheimer's Disease and Related Dementias (ADRD). The research deliverables include...
- Federal Project Grant Summary Rowan University received a $530,469 Project Grant award from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), effective August 15, 2025, through July 31, 2028. The grant supports biomedical research investigating the role of orosomucoid1 in skeletal muscle aging and sarcopenia—age-related muscle loss and functional decline. The research focuses on determining whether orosomucoid1 is necessary for improvements in muscle...
- Federal Project Grant Award Summary Oregon Health & Science University has been awarded $471,885 by the National Institute on Aging under the Aging Research program (CFDA 93.866) to conduct a two-year research project (Award Date: June 1, 2025; Completion Date: May 31, 2027) investigating the mechanisms by which hyaluronan protects brain vascular endothelial cells from ferroptosis. The research addresses vascular contributions to cognitive impairment and dementia (VCID), the second leading...
The University of Arkansas for Medical Sciences received a $487,847 Project Grant from the National Institute on Aging under the Aging Research program (CFDA 93.866) effective June 1, 2026, through March 31, 2031. The award supports research investigating the role of autophagy—a cellular recycling process—in skeletal diseases, with particular focus on understanding how autophagy deficiency contributes to reduced bone formation in aging and osteogenesis imperfecta (OI). The research employs advanced methodologies including single-cell RNA sequencing (scRNA-seq) and CRISPR activation techniques to elucidate the mechanisms by which autophagy insufficiency leads to increased cellular senescence in osteoblast lineage cells and to identify therapeutic targets for improving bone mass and strength. The project delivers basic biomedical research products directed toward greater understanding of aging-related skeletal diseases through comparative molecular and cellular analyses. Specifically, the research generates scientific knowledge regarding the relationship between autophagy dysfunction and osteoblast senescence in aging and OI, utilizing innovative genetic models and transcriptomic profiling to characterize biological processes altered in these conditions. Findings from this research are expected to support the National Institute on Aging's mission to identify mechanisms and potential therapeutic interventions for age-related diseases and special problems affecting aging populations.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $487.8k | 5/26/26 |