Project Grant R21AG104417
- The National Institute on Aging awarded Baylor College of Medicine $651,838 under the Aging Research program (CFDA 93.866) on September 1, 2026, to define the regulatory mechanisms of periosteal skeletal stem cells (P-SSCs) in bone maintenance and repair with aging. The research addresses the clinical problem that bone healing capacity declines with age, creating significant healthcare burden from delayed healing and non-union in aged bone defects. The project will characterize the in vivo niche...
- The National Institute on Aging awarded The Trustees of the University of Pennsylvania $723,105 on May 15, 2026, under the Aging Research program (CFDA 93.866) to investigate activin A signaling pathways in bone repair mechanisms. The work targets delayed and nonunion fractures, which occur in 5–10% of fractures and pose substantial morbidity and quality-of-life impacts, particularly in aging populations where geriatric fractures are rising in prevalence. The recipient will conduct research on...
- The National Institute on Aging, part of the Department of Health and Human Services National Institutes of Health, awarded $1.373 million to the University of California, Davis on May 15, 2026 under the Aging Research program (CFDA 93.866) to investigate skeletal stem cell-based cartilage regeneration in aged and osteoarthritic joints. The recipient will elucidate cellular dynamics and molecular mechanisms underlying skeletal stem cell (SSC)-mediated cartilage repair, with particular focus on...
- The National Institute on Aging awarded University of Massachusetts Medical School $626,409 on February 1, 2026, under the Aging Research program (CFDA 93.866) to investigate how aging impairs wound healing through hematopoietic stem cell dysfunction. The research uses single-cell epigenomics to characterize how aging affects gene expression of individual immune cells and the epigenetic modifications that regulate that expression. The project addresses whether aging impairs cutaneous wound...
- The National Institute on Aging awarded Duke University $470,881 on August 15, 2026, under the Aging Research program (CFDA 93.866) to investigate reductive tricarboxylic acid (TCA) cycle metabolism in muscle stem cell aging. The research examines glutamine metabolism pathways in muscle stem cells and how age-related dysfunction in these pathways impairs tissue regeneration. The project uses stable isotope-enabled metabolic flux analysis to characterize both oxidative and reductive glutamine...
- The National Institute on Aging awarded Duke University $1.597 million on September 15, 2025, under the Aging Research program (CFDA 93.866) to support research on epitranscriptomic regulation of microglia in Alzheimer's disease. The research investigates how m6a methylation of adenosine residues in messenger RNA regulates microglial cell function and transitions between resting and activated states during Alzheimer's disease pathogenesis, with the goal of identifying novel...
- The National Institute on Aging awarded Yale University $544,318 under the Aging Research program (CFDA 93.866) on June 1, 2026, to conduct research on immunometabolic regulation of inflammaging by nerve-associated macrophages (NAMs). The project investigates how nerve-associated macrophages—a subset of macrophages residing on sympathetic nerve fibers—regulate the sympathetic nervous system and innate immune response to control chronic inflammation associated with aging. The research addresses...
- The National Institute on Aging awarded the University of Rochester $227,250 on September 1, 2026, under the Aging Research program (CFDA 93.866) to investigate macrophage spatial heterogeneity in regulating hematopoietic aging and inflammation-related stem cell dysfunction. The research examines how resident macrophages in different bone marrow microenvironments regulate hematopoietic stem cell (HSC) division symmetry and fitness during aging. Using intravital microscopy and HSC reporter...
- The National Institute on Aging awarded The Washington University $518,372 on May 1, 2026, under the Aging Research program (CFDA 93.866) to investigate bone marrow adipocyte regulation of skeletal health and neural control of bone remodeling. The research defines neuro-adipose-bone crosstalk within the skeletal niche to develop strategies supporting bone health and preventing age- and disease-associated bone loss. Specific aims include establishing mechanisms of bone marrow adipocyte-mediated...
- The National Institute on Aging awarded Beth Israel Deaconess Medical Center, Inc. $518,555 on September 1, 2026, under the Aging Research program (CFDA 93.866) to develop spatially validated human lymphoid follicles-on-chip for modeling inflammaging and age-related immune dysfunction. The recipient will establish a lymphoid follicle organ-on-chip platform that recapitulates key hallmarks of human lymphoid function, including germinal center formation, AID expression, and antiviral antibody...
The National Institute on Aging awarded Duke University $444,125 under the Aging Research program (CFDA 93.866) on August 15, 2026, to investigate B cell rejuvenation as a mechanism to improve bone fracture healing in aged populations. The project will test whether maresin 1 treatment of B cells isolated from aged mice can restore interleukin-7 receptor (IL7R) expression, enhance anti-inflammatory cytokine secretion, and improve fracture healing outcomes when injected at fracture sites. The research uses single-cell RNA sequencing and flow cytometry to characterize age-dependent changes in the B cell population within the fracture callus, building on preliminary findings showing that maresin 1 treatment rescues IL7R expression and increases IL-10 secretion while reducing interferon gamma production in aged B cells. The project will complete specific aims testing whether maresin 1-treated B cells improve aged fracture healing compared to vehicle-treated controls. Work is performed in Durham, North Carolina. The period of performance extends from the award date through July 31, 2028. This is a Project Grant, an assistance type under the Aging Research program supporting biomedical and behavioral research directed toward understanding aging processes and age-related diseases.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $444.1k | 8/10/26 |