Project Grant R21AG103300
- The National Institute on Aging awarded Baylor College of Medicine $101,052 under the Aging Research program (CFDA 93.866) on December 25, 2026, to characterize the role of CARHSP1 (calcium-regulated heat stable protein 1) in the aging brain and Alzheimer's disease. The funded research will define the role of CARHSP1 and its Drosophila homolog CG9705 in normal neuronal function through loss- and gain-of-function modeling; identify genetic interactions that mediate CARHSP1-induced toxicity by...
- The National Institute on Aging awarded Baylor College of Medicine $440,000 on May 1, 2026, under the Aging Research program (CFDA 93.866) to conduct single-cell transcriptomic and epigenomic analysis of budding yeast aging. The project, titled "Beyond Genetics: Unveiling Epigenetic Drivers of Lifespan Heterogeneity Through Yeast Single-Cell Aging Atlases," investigates the molecular basis for lifespan variation in genetically identical organisms raised in controlled conditions. The...
- This Project Grant award from the National Institutes of Health (NIH) Office of the Director under the Trans-NIH Research Support program (CFDA 93.310) provides $1,359,000.00 to Baylor College of Medicine to conduct research on age-associated cellular and molecular adaptations that enable whole-organism rejuvenation in the highly regenerative flatworm Schmidtea mediterranea. The research aims to (1) determine how age-associated damage manifests in asexual planaria throughout their lifecycle...
- The National Institute on Aging awarded Baylor College of Medicine $1,343,997 on March 1, 2026, under the Aging Research program (CFDA 93.866) to generate tool compounds and chemical probes for putative Alzheimer's disease and related dementia therapeutic targets using DNA-encoded libraries and machine learning. The project will perform DEL selections on AD/ADRD targets, synthesize enriched DEL hits, and test them for activity. Baylor will share publicly the selection input of 12 DNA-encoded...
- The National Institute on Aging awarded Baylor College of Medicine $651,838 under the Aging Research program (CFDA 93.866) on September 1, 2026, to define the regulatory mechanisms of periosteal skeletal stem cells (P-SSCs) in bone maintenance and repair with aging. The research addresses the clinical problem that bone healing capacity declines with age, creating significant healthcare burden from delayed healing and non-union in aged bone defects. The project will characterize the in vivo niche...
- The National Institute on Aging, part of the Department of Health and Human Services, awarded Baylor College of Medicine $440,000 on September 1, 2026, under the Aging Research program (CFDA 93.866) to develop human proteins that suppress DNA damage as potential agents for cellular and genome protection. The project tests the hypothesis that human proteins functioning as molecular shields can protect cells and DNA from damage, reduce somatic mutation rates, and potentially delay or prevent...
- The National Institute of General Medical Sciences awarded Baylor College of Medicine $440,000 on February 13, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate the physical principles governing nucleolar condensates and their role in ribosome biogenesis. The research develops quantitative microscopy methods to determine how nucleolar composition changes in response to cellular stimuli and during cellular transitions. The work tests the hypothesis...
- The National Institute on Aging awarded Baylor College of Medicine $689,188 under the Aging Research program (CFDA 93.866) on August 15, 2026, to investigate hepatic epigenetic memory mechanisms and metabolic resilience in aging-related metabolic disease. The award funds research examining how high-level estrogen exposure—mimicking pregnancy—initiates persistent chromatin accessibility and histone hyperacetylation at an enhancer region of the transcription factor BNC2 in liver tissue. The...
- The National Institute on Aging awarded Texas A&M University $640,059 on September 1, 2026, under the Aging Research program (CFDA 93.866) to investigate cerebellar changes in aging and cognitive decline through longitudinal neuroimaging and functional analysis. The project examines how cerebellar structure, white matter circuits, and task-based functional activation change over time in older adults, with particular focus on individuals experiencing subjective cognitive decline—self-reported...
- The National Institute on Aging awarded Drexel University $420,554 under Aging Research (CFDA 93.866) on September 1, 2026, to establish an integrated system for studying senescence and aging in the central nervous system. The award funds two research aims: characterization of the molecular and functional consequences of senescence in astrocyte and neuronal cultures, and evaluation of senescence impact in a multicellular context using hiPSC-derived vascularized cortical organoids. Single-cell...
The National Institute on Aging awarded Baylor College of Medicine $430,212 under the Aging Research program (CFDA 93.866) on September 1, 2026, for an exploratory R21 project to establish Procotyla fluviatilis, a North American planarian species, as a comparative model for aging research. The funded work will define how stem cell function and tissue structure change across the flatworm's seasonal life cycle, map age-associated cellular and transcriptional changes using single-cell sequencing, and test whether conserved genetic and environmental regulators of lifespan operate in this regenerative species. P. fluviatilis undergoes rapid somatic decline following egg-laying despite maintaining abundant stem cells and robust regenerative abilities, offering a unique opportunity to dissect relationships between regeneration, tissue maintenance, and longevity. By integrating stem cell biology, molecular genetics, and functional perturbation, the project aims to reveal how regeneration intersects with loss of somatic maintenance, generating insights into conserved mechanisms governing tissue health and longevity. Performance occurs in Houston, Texas through August 31, 2028. Baylor College of Medicine is a private non-profit research-intensive academic health sciences institution with substantial NIH portfolio activity; the institution competes full-and-open across its federal grants, which numbered 4,839 awards as of 2026 Q4.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $430.2k | 8/31/26 |