Project Grant R01AG099235
- The National Institute on Aging awarded The Leland Stanford Junior University $165,887 on August 5, 2026, under the Aging Research program (CFDA 93.866) to conduct research on human adult hematopoietic stem cells through aging, inflammation, and clonal selection. The research addresses functional changes in aging hematopoietic stem cells (HSCs) and their role in maintaining blood cell production. The project investigates how aging HSCs become heterogeneous in function, examining reduced...
- The National Institute on Aging awarded $648,930 to the Regents of the University of California, doing business as University of California, Berkeley, on August 15, 2026, under the Aging Research program (CFDA 93.866) to develop human stem cell-based microphysiological systems for aging research. The recipient will create a novel human aging-on-a-chip platform integrating fat and liver tissues derived from human induced pluripotent stem cells (hiPSCs) and microfluidics using serum from young...
- The National Institute on Aging, part of the Department of Health and Human Services, awarded $533,500 to the Buck Institute for Research on Aging on July 15, 2026, under the Aging Research program (CFDA 93.866). The award funds examination of the role of autonomic innervation in muscle stem cell aging. The research investigates the functional link between autonomic nervous system neurons and muscle stem cells using Drosophila melanogaster as a model organism. The project will refine...
- The National Heart, Lung, and Blood Institute awarded the University of California, San Diego $1,601,981 on September 15, 2025, under the Cardiovascular Diseases Research program (CFDA 93.837) to investigate protein aggregation mechanisms in hematopoietic stem cells and their relationship to stem cell aging. The research examines how hematopoietic stem cells traffic misfolded proteins to aggresomes—cytosolic inclusion bodies that are substrates for selective autophagy—and tests the hypothesis...
- The National Institute on Aging awarded the University of Rochester $227,250 on September 1, 2026, under the Aging Research program (CFDA 93.866) to investigate macrophage spatial heterogeneity in regulating hematopoietic aging and inflammation-related stem cell dysfunction. The research examines how resident macrophages in different bone marrow microenvironments regulate hematopoietic stem cell (HSC) division symmetry and fitness during aging. Using intravital microscopy and HSC reporter...
- The National Institute on Aging awarded Dana-Farber Cancer Institute, Inc. $1,526,573 on July 15, 2026, under the Aging Research program (CFDA 93.866) to conduct research on rejuvenation of aged hematopoietic stem cells and bone marrow niche function via mitochondrial engineering. The research addresses how aging impairs hematopoietic stem cell (HSC) transplantation success by driving mitochondrial dysfunction in donor cells. The work investigates mitochondrial transfer between HSCs and...
- The National Institute on Aging awarded University of Massachusetts Medical School $626,409 on February 1, 2026, under the Aging Research program (CFDA 93.866) to investigate how aging impairs wound healing through hematopoietic stem cell dysfunction. The research uses single-cell epigenomics to characterize how aging affects gene expression of individual immune cells and the epigenetic modifications that regulate that expression. The project addresses whether aging impairs cutaneous wound...
- The National Institute on Aging, part of the Department of Health and Human Services National Institutes of Health, awarded $1.373 million to the University of California, Davis on May 15, 2026 under the Aging Research program (CFDA 93.866) to investigate skeletal stem cell-based cartilage regeneration in aged and osteoarthritic joints. The recipient will elucidate cellular dynamics and molecular mechanisms underlying skeletal stem cell (SSC)-mediated cartilage repair, with particular focus on...
- The National Institute on Aging awarded Dana-Farber Cancer Institute, Inc. $130,680 on August 5, 2026, under the Aging Research program (CFDA 93.866) to investigate epigenetic drivers of stem cell fitness in aging hematopoiesis. The research elucidates how disrupted DNA methylation drives the defective inflammatory response of TET2-mutant hematopoietic stem cells under chronic IL-6 treatment and contributes to their enhanced fitness in aging populations. Over 75% of individuals aged 70 and older...
- The National Institute on Aging awarded Baylor College of Medicine $651,838 under the Aging Research program (CFDA 93.866) on September 1, 2026, to define the regulatory mechanisms of periosteal skeletal stem cells (P-SSCs) in bone maintenance and repair with aging. The research addresses the clinical problem that bone healing capacity declines with age, creating significant healthcare burden from delayed healing and non-union in aged bone defects. The project will characterize the in vivo niche...
The National Institute on Aging awarded the University of California, Berkeley $598,837 on August 15, 2026, under the Aging Research program (CFDA 93.866) to investigate how hematopoietic stem cell aging affects distant tissues and organismal aging. The research will characterize a mouse model that reverses hematopoietic stem cell (HSC) aging by measuring changes in healthspan and lifespan and deciphering the molecular and cellular mechanisms underlying those alterations. The work tests the hypothesis that because the blood system supports all tissues, HSC aging manifests in blood cell progeny and therefore affects distant tissue function and aging across the organism. Clinic-ready compounds will be tested for reversing the effects of HSC aging on tissue functions and organismal aging. This research addresses how somatic mutations accumulating in HSCs over time—which increase risk for blood diseases, myocardial infarctions, strokes, vascular complications of type 2 diabetes, and earlier mortality—may impact distant tissues and contribute to multi-organ dysfunction and multi-morbidities in aging. Performance occurs in Berkeley, California. The award period runs through July 31, 2031.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $598.8k | 8/10/26 |