Project Grant R01AG093759
- The National Institute on Aging awarded Yale University $507,741 under the Aging Research program (CFDA 93.866) on August 1, 2026, to define the spatial relationship between early endosomal abnormalities, amyloid pathology, and early-stage tau hyperphosphorylation in primate models of sporadic Alzheimer's disease. The project addresses a gap in understanding the earliest molecular convergence points in Alzheimer's pathology. While soluble phosphorylated tau at threonine 217 (pT217tau) and...
- The National Institute on Aging awarded $780,217 to the University of Connecticut Health Center on September 1, 2026, under the Aging Research program (CFDA 93.866) to conduct longitudinal imaging of prefrontal cholinergic dynamics and cognitive flexibility in an Alzheimer's disease model. The research combines chronic two-photon imaging, fluorescent acetylcholine reporting, in vivo beta-amyloid labeling, and cell-type-specific chemogenetic and optogenetic control to test whether amyloid-beta...
- The National Institute on Aging awarded Marquette University $309,000 on May 15, 2026, under the Aging Research program (CFDA 93.866) to conduct longitudinal imaging studies in a preclinical Alzheimer's disease model aimed at identifying early biomarkers of cognitive decline. The project uses in vivo calcium imaging of prefrontal cortical neuronal ensembles and two-photon imaging of amyloid-beta deposits in a transgenic rat model to track changes in genetically defined excitatory and...
- The National Institute on Aging awarded the University of Pittsburgh $664,619 on January 1, 2026, under the Aging Research program (CFDA 93.866) to develop multiscale computational and experimental models of neurometabolic coupling across age-related cognitive decline and late-onset Alzheimer's disease. The research integrates in vivo two-photon microscopy, multispectral wide-field imaging, and magnetic resonance imaging to characterize the relationship between neuronal activity and metabolic...
- The National Institute on Aging awarded Icahn School of Medicine at Mount Sinai $704,145 on September 1, 2026, under the Aging Research program (CFDA 93.866) to develop and apply computational methods for inferring the natural history of Alzheimer's disease from sparse longitudinal molecular and neuroimaging data. The recipient will develop an innovative approach that leverages temporal signal in sparse longitudinal datasets to reconstruct the timeline of Alzheimer's disease progression and...
- The National Institute on Aging awarded New York University $642,063 under the Aging Research program (CFDA 93.866) on January 15, 2026, to investigate gabaergic circuit targets for modulating entorhinal cortex and hippocampal dynamics in Alzheimer's disease. The research examines vasoactive intestinal peptide and cholecystokinin inhibitory neuron microcircuits within hippocampal area CA1, with the hypothesis that modulating activity in these circuits can improve lateral entorhinal cortex–CA1...
- The National Institute on Aging awarded Exqor Technologies Inc. $999,176 on September 22, 2025, under the Aging Research program (CFDA 93.866) to develop non-radioactive nanoprobes for magnetic resonance imaging of tropomyosin receptor kinase B (TrkB) in Alzheimer's disease. The project addresses early detection of decreased TrkB expression, which is implicated in impaired neurogenesis, synaptic damage, and neuronal death in Alzheimer's disease. The recipient is developing a two-part...
- The National Institute on Aging awarded Yale University $544,318 under the Aging Research program (CFDA 93.866) on June 1, 2026, to conduct research on immunometabolic regulation of inflammaging by nerve-associated macrophages (NAMs). The project investigates how nerve-associated macrophages—a subset of macrophages residing on sympathetic nerve fibers—regulate the sympathetic nervous system and innate immune response to control chronic inflammation associated with aging. The research addresses...
- The National Institute on Aging awarded the University of Virginia $583,815 on August 15, 2026, under the Aging Research program (CFDA 93.866) to support research into oligodendrocyte lineage dysfunction during aging and Alzheimer's disease. The project aims to understand how myelin loss—a pathology common to both aging and Alzheimer's disease—develops in the central nervous system and to identify therapeutic targets for cognitive impairment. The research focuses on oligodendrocyte precursor...
- The National Institute on Aging awarded the University of Rochester $656,829 under the Aging Research program (CFDA 93.866) on January 1, 2026, to investigate selective vulnerability of the fronto-insular network in aging and Alzheimer's disease through integrated structural, functional, and molecular analyses in mouse models. The research integrates in vivo two-photon imaging to track dendritic spine dynamics and dopaminergic terminal remodeling, fiber photometry to measure neural activity...
The National Institute on Aging awarded Yale University $638,941 under the Aging Research program (CFDA 93.866) on September 1, 2026, to conduct metabolic imaging of olfactory bulb dysfunction in Alzheimer's disease. The research will use longitudinal magnetic resonance imaging (structural MRI and functional MRI) and magnetic resonance spectroscopy to identify structural, functional, and metabolic alterations in the olfactory bulb across transgenic TGF344-AD rats and age-matched wild-type controls from 3 to 15 months of age. The study integrates olfactory behavioral and memory testing to characterize early network dysfunction preceding overt cognitive symptoms. Work will quantify baseline metabolic activity and mitochondrial function using in vivo 31P and 1H-MRS to detect bioenergetic impairments, then determine neuron and astrocyte-specific metabolic deficits using 1H[13C]-MRS validated by histological analysis of amyloid-beta, tau, GFAP, and markers of axonal and synaptic integrity and dystrophy. The research aims to establish the olfactory bulb's value as an early, non-invasive biomarker of Alzheimer's disease progression by defining the mechanistic sequence linking metabolic dysfunction to network disruption and behavioral decline. Performance occurs in Connecticut. The award covers the period from September 1, 2026, through June 30, 2031. This is a Project Grant, the standard assistance type for investigator-initiated research under the National Institute on Aging's portfolio.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $0 | 9/3/26 | ||
| Not listed | $638.9k | 8/25/26 |