Project Grant R44AG090240
- This $500,000 Project Grant was awarded on September 15, 2024 by the National Institute on Aging (CFDA 93.866 Aging Research program) to Neucyte Inc., a minority-owned small business specializing in advanced biomedical research and development. The funding will support the development of a miniaturized "mini-brain" microphysiological system (MPS) platform using Alzheimer's disease (AD) patient-derived cells. The goal is to create a scalable, reproducible in vitro brain model that can...
- This $499,940 federal Project Grant was awarded on September 11, 2025 by the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866) to Adeptrix Corp, a biotechnology company based in Boston, MA. The grant funds the development of TAUTRACE, a novel ultrasensitive immunoassay platform capable of quantifying distinct molecular forms of the tau protein in cerebrospinal fluid and blood plasma at femtogram-per-milliliter concentrations. This technology aims to address the...
- This $287,118 Project Grant was awarded on September 1, 2023 by the National Institute on Aging (NIA) under the Aging Research (CFDA 93.866) grant program. The grant will fund the development of techniques to use deep transfer learning and multimodal data, including brain MRIs, genetic information, and cognitive tests, to enable the early detection and forecasting of Alzheimer's disease progression. The University of Massachusetts (UMass), as the prime awardee, will create an end-to-end...
- This $4.46 million project grant from the National Institute on Aging, part of the Department of Health and Human Services, supports research under the Aging Research program (CFDA 93.866) to develop a new in vivo magnetic resonance imaging biomarker for early detection of Alzheimer's disease neurodegeneration. Specifically, the awardee, Washington University, will utilize quantitative gradient recalled echo MRI techniques to identify two types of hippocampal tissue in preclinical and mild...
- The National Institute on Aging (NIA) awarded a $506,061 Project Grant under the Aging Research Federal Grant Program (CFDA 93.866) to Redwood Neuro Inc. of Irvine, CA. The grant, awarded on September 15, 2025, aims to develop the SIMOLISA platform, an innovative and cost-effective technology designed to enable earlier and more sensitive detection of Alzheimer's disease biomarkers like p-tau proteins and β-amyloid through a blood-based assay. Unlike conventional systems that require expensive...
- The National Institute on Aging (NIA) awarded a $475,014 Project Grant to Enrectec LLC, a for-profit woman-owned limited liability company located in Sioux Falls, South Dakota. The grant, funded under the NIA's Aging Research program (CFDA 93.866), supports the development of a non-erythropoietic, neurotrophic therapeutic molecule for treating the cognitive deficits associated with Alzheimer's disease. The project aims to conduct Phase I feasibility studies, including bioreactor scale-up of...
- This $497,878 Project Grant award was provided by the National Institute on Aging (NIA) under the Aging Research federal grant program (CFDA 93.866) to support a Phase 0 study to evaluate the in vivo characteristics of a myeloperoxidase-targeting PET agent in healthy volunteers and early Alzheimer's disease (AD) patients. The key objectives of this research project are to develop and validate a PET imaging agent, 18F-EH301, that can cross the blood-brain barrier and enable non-invasive detection...
- The National Institute on Aging (NIA) awarded a $1,783,700.00 Project Grant under the Aging Research program (CFDA 93.866) to the University of Illinois to develop novel blood-brain barrier permeable multimodal imaging agents for the diagnosis of neurodegenerative diseases, with a focus on Alzheimer's disease and related dementias. The 3-year grant aims to employ organic and inorganic chemical design principles to generate diagnostic agents capable of detecting protein aggregation,...
- This $481,250 Project Grant was awarded by the National Institute on Aging (CFDA 93.866 Aging Research) to Vanderbilt University Medical Center (VUMC) on September 1, 2024. The award supports the development of an innovative, non-invasive MRI imaging technique to assess membrane lipid properties in Alzheimer's disease (AD). The key objectives are to: 1) verify the relationship between the MRI nuclear Overhauser enhancement (NOE) signal and lipid properties using reconstituted phospholipid...
- This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $483,346 to Meganano Diagnostics Inc. to develop an RT-qPCR assay for early diagnosis of Alzheimer's disease (AD). The project aims to leverage peripheral blood mononuclear cell (PBMC) samples from the Florida Alzheimer's Research Center to analyze T cell receptor (TCR) clonality changes in CD8+ T cells as a potential biomarker for AD and mild cognitive impairment (MCI). The award period runs...
This $499,588 Project Grant was awarded on September 22, 2025 by the National Institute on Aging (NIA) under the Aging Research federal grant program (CFDA 93.866) to Exqor Technologies Inc., a small disadvantaged business located in Boston, MA. The goal of this project is to develop non-radioactive nanoprobes that can be used for magnetic resonance imaging (MRI) of the tropomyosin receptor kinase B (TrkB) protein, which is implicated in the pathology of Alzheimer's disease (AD). The nanoprobes are intended to enable early detection of decreased TrkB expression, which is associated with impaired neurogenesis, synaptic damage, and neuronal death in AD. This work aims to provide a new imaging tool to support rapid prevention and treatment of AD compared to the limitations of current positron emission tomography (PET) techniques for TrkB receptor imaging.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $499.6k | 9/19/25 |