Project Grant R01AG096593
- The National Institute on Aging awarded Duke University $1.597 million on September 15, 2025, under the Aging Research program (CFDA 93.866) to support research on epitranscriptomic regulation of microglia in Alzheimer's disease. The research investigates how m6a methylation of adenosine residues in messenger RNA regulates microglial cell function and transitions between resting and activated states during Alzheimer's disease pathogenesis, with the goal of identifying novel...
- The National Institute on Aging awarded the University of Virginia $131,166 on August 5, 2026, under the Aging Research program (CFDA 93.866) to investigate the role of microglia-pericyte signaling in maintaining basal capillary tone in health and Alzheimer's disease. The research examines how microglia, brain-resident immune cells implicated in Alzheimer's disease pathology, regulate blood flow through capillaries by modulating pericyte function via cyclooxygenase-1 (COX1) and prostaglandin...
- The National Institute on Aging awarded Virginia Commonwealth University $552,883 on January 1, 2026, under the Aging Research program (CFDA 93.866) to conduct research on the selective vulnerability of cholinergic neurons in Alzheimer's disease. The award is a Project Grant with performance extending through November 30, 2030, at the Richmond, Virginia campus. The funded research investigates how soluble oligomeric amyloid-beta 42 (oAB42) drives selective degeneration of basal forebrain...
- The National Institute on Aging awarded the University of Virginia $433,417 on September 1, 2026, under the Aging Research program (CFDA 93.866) to investigate the role of hippocampal perineuronal net complexity in Alzheimer's disease-associated social memory dysfunction. The research examines how disruptions in perineuronal nets—specialized extracellular matrix structures surrounding neurons in the hippocampal CA2 region—contribute to social memory deficits in Alzheimer's disease. The project...
- The National Institute on Aging awarded the University of Virginia $2.877 million on July 1, 2026, under the Aging Research program (CFDA 93.866) to investigate microglia's role in neurovascular coupling and hypertensive cerebral small vessel disease. The project will test the hypothesis that microglial dysregulation of cerebral blood flow leads to hypertensive vascular dementia and endothelial rarefaction as common pathological events with Alzheimer's disease. Aim 1 will employ laser speckle...
- The National Institute on Aging awarded New York University $642,063 under the Aging Research program (CFDA 93.866) on January 15, 2026, to investigate gabaergic circuit targets for modulating entorhinal cortex and hippocampal dynamics in Alzheimer's disease. The research examines vasoactive intestinal peptide and cholecystokinin inhibitory neuron microcircuits within hippocampal area CA1, with the hypothesis that modulating activity in these circuits can improve lateral entorhinal cortex–CA1...
- The National Institute on Aging, part of the Department of Health and Human Services, awarded Duke University $493,972 on January 1, 2026, under the Aging Research program (CFDA 93.866) to investigate cell type-specific epitranscriptomic regulation in the brain during aging and Alzheimer's disease. The research will determine how age-dependent differential methylation of adenosine (M6A) in distinct brain cell types influences the expression of genes associated with Alzheimer's disease. The...
- The National Institute on Aging awarded $427,625 to The Washington University on September 1, 2026, under the Aging Research program (CFDA 93.866) to probe cerebellar cortex computations in Alzheimer's disease. The work examines cerebellar nodulus and uvula function in two Alzheimer's disease mouse models—APP/PS1 and 3XTG-AD—at 3, 6, and 12 months of disease progression to assess how hallmarks of Alzheimer's disease contribute to cerebellar dysfunction. The project tests the hypothesis that...
- The National Institute on Aging awarded the University of Pittsburgh $664,619 on January 1, 2026, under the Aging Research program (CFDA 93.866) to develop multiscale computational and experimental models of neurometabolic coupling across age-related cognitive decline and late-onset Alzheimer's disease. The research integrates in vivo two-photon microscopy, multispectral wide-field imaging, and magnetic resonance imaging to characterize the relationship between neuronal activity and metabolic...
- The National Institute on Aging, part of the Department of Health and Human Services, awarded the University of California, Los Angeles $146,750 under the Aging Research program (CFDA 93.866) on July 1, 2026, to identify molecular-neuropathological signatures in Alzheimer's disease, frontotemporal lobar degeneration, and long COVID. The recipient will employ single-cell spatial multi-omics on postmortem brain tissues to characterize molecular and cellular alterations linked to selective...
The National Institute on Aging awarded the University of Virginia $583,815 on August 15, 2026, under the Aging Research program (CFDA 93.866) to support research into oligodendrocyte lineage dysfunction during aging and Alzheimer's disease. The project aims to understand how myelin loss—a pathology common to both aging and Alzheimer's disease—develops in the central nervous system and to identify therapeutic targets for cognitive impairment. The research focuses on oligodendrocyte precursor cells and their dependence on norepinephrine signaling, particularly in relation to dysfunction of the locus coeruleus, the brain region most affected by early Alzheimer's pathology. Work is performed in Charlottesville, Virginia, with a period of performance extending through May 31, 2031. This Project Grant supports biomedical research directed toward understanding the aging process and diseases affecting older adults, consistent with the National Institute on Aging's mission to prevent and treat Alzheimer's disease and related dementias.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $93.4k | 8/18/26 | ||
| Not listed | $490.4k | 8/12/26 |