Project Grant R01AG100044
- Federal Grant Award Summary Yale University received a $746,160 Project Grant from the National Institute on Aging (Aging Research program, CFDA 93.866) awarded on March 20, 2026, with completion targeted for February 28, 2031. The grant funds research investigating how peripheral inflammation interacts with aging to increase dementia risk. The research will generate scientific knowledge regarding the cellular and molecular mechanisms through which acute and chronic peripheral immune...
- Federal Project Grant Award Summary Yale University received a $681,277 Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), awarded May 15, 2026, with a completion date of April 30, 2031. This grant funds research investigating cell size inheritance and innate immune memory, with particular focus on understanding how enlarged immune cells maintain proliferative capacity without transitioning into senescence. The research examines the role of...
- Federal Grant Award Summary Yale University received a $380,748 Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), awarded September 1, 2025, with completion targeted for May 31, 2028. The research project, conducted in Boston, MA, investigates the immunological mechanisms underlying exercise's beneficial effects on skeletal muscle aging. The grant supports scientific research aimed at understanding how mechanical stress-induced immune...
- Federal Project Grant Award Summary Yale University received a $461,146 Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), awarded on May 15, 2025, with completion targeted for April 30, 2027. The award funds research investigating the dysregulation of cortical astrocytes in Alzheimer's disease (AD) models. The primary deliverable is novel scientific research employing advanced mesoscopic imaging techniques to longitudinally measure...
- Federal Grant Award Summary Yale University received a $921,822 Project Grant from the National Institute on Aging under the Aging Research program (CFDA 93.866) awarded June 9, 2025, with completion targeted for May 31, 2027. The grant funds research investigating lysosomal regulation and functions of Tank-Binding Kinase 1 (TBK1) in neurodegenerative diseases, specifically amyotrophic lateral sclerosis and frontotemporal dementia. The research will deliver molecular and mechanistic insights...
- Federal Grant Award Summary Yale University received a $461,146 Project Grant from the National Institute on Aging under the Aging Research program (CFDA 93.866) awarded May 15, 2025, with completion targeted for April 30, 2027. The project, titled "Toward Developing a Navigation Model of the Aging Brain in the Marmoset," focuses on understanding the physiological function and organization of the entorhinal cortex (ERC) in marmosets to advance knowledge of Alzheimer's disease pathology...
- Federal Grant Award Summary Yale University received a $735,631 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded April 1, 2026, with a completion date of March 31, 2031. The award funds investigator-initiated biomedical research examining the origin, function, and immune-modulating properties of a novel population of CX3CR1+ neutrophils—specialized white blood cells distinct from...
- Federal Project Grant Award Summary Yale University received a $461,311 Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866) for a two-year period from May 1, 2026 through April 30, 2028. The funded research project, titled "Vascular Smooth Muscle Aging and the Epigenetic Clock," will be conducted at Yale's New Haven, Connecticut facility and aims to develop novel methodologies for assessing and reversing biological aging in vascular...
- Federal Project Grant Award Summary Yale University received a $461,313 Project Grant award from the National Institute on Aging (Aging Research program, CFDA 93.866) effective June 1, 2025 through May 31, 2027. The grant supports research investigating the role of cysteine string protein alpha (CSPα) in presynaptic autophagy and its relationship to neurodegeneration. The project will generate scientific knowledge products including characterization of synaptic vesicles, autophagosomes, and...
- Federal Grant Award Summary Yale University received a $4.9 million Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded on July 14, 2025, with a completion date of June 30, 2029. The grant supports biomedical research investigating the mechanistic pathways by which gut microbiota and white adipose tissue control the CD4 T-cell compartment and facilitate T-cell migration from the...
Yale University received a Project Grant of $544,318 from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), effective June 1, 2026 through May 31, 2031. This research award supports an investigation into immunometabolic regulation of inflammaging through the study of nerve-associated macrophages (NAMs). The project will deliver scientific knowledge regarding how NAMs—specialized immune cells residing on sympathetic nerve fibers—regulate nerve integrity, neurotransmitter bioavailability, and tissue metabolic function as part of the aging process. Research outputs will include characterization of NAM functional heterogeneity, examination of age-related decline in NAM repair capacity, and evaluation of NAMs as neuro-immune buffers that modulate sympathetic nervous system responses through catecholamine degradation. The research conducted at Yale University's New Haven, Connecticut facility will generate insights into chronic inflammation (inflammaging) mechanisms and their relationship to age-related tissue dysfunction. Specific research deliverables will include molecular and cellular biology data, intra-vital microscopy characterization of NAM morphology and behavior, and experimental findings from transgenic mouse models designed to illuminate the intersection of neural and innate immune sensing in aging biology. These research products directly support the NIA's mission to advance understanding of aging processes and develop evidence-based approaches to preventing and treating age-related disease.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $544.3k | 6/3/26 |