Project Grant R01AG094086
- Federal Project Grant Award Summary New York University School of Medicine received a $130,302 Project Grant award from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), effective July 15, 2025, with an ultimate completion date of March 31, 2030. This research award supports a multi-aim investigation into the selective vulnerability of basal forebrain cholinergic neurons (BFCNs) to tau pathology in Alzheimer's disease. The project will deliver scientific...
- Federal Grant Award Summary New York University received a $1,012,879 Project Grant from the National Institute on Aging under the Aging Research program (CFDA 93.866), awarded September 5, 2025, with completion anticipated by August 31, 2029. The award supports the development of three novel statistical machine learning methods designed to enhance the understanding, diagnosis, and prediction of Alzheimer's disease using multi-view data integration. The primary deliverables include: (1) a...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded The Trustees of Columbia University in the City of New York a $2,957,210 Project Grant under the Aging Research program (CFDA 93.866) on September 15, 2025, with a completion date of August 31, 2029. This award funds comprehensive biomedical research investigating the role of CD44 astrocytes in Alzheimer's disease (AD) pathophysiology. The research project will elucidate the functional mechanisms by which CD44 upregulation...
- Federal Grant Award Summary New York University was awarded $1,049,816 through the National Institute on Aging's Aging Research program (CFDA 93.866) effective May 15, 2025, with a completion date of January 31, 2029. This project grant supports the development of statistical methodologies to improve the estimation and prediction of Alzheimer's disease (AD) progression using longitudinal cohort study data. The research addresses critical gaps in current analytical approaches by developing...
- Federal Grant Award Summary Award Overview New York University School of Medicine received a $712,578 Project Grant from the National Institute on Aging (Aging Research program, CFDA 93.866) effective February 1, 2026, through December 31, 2030. This prospective research study investigates the relationship between viral infections and Alzheimer's disease (AD) risk in aging populations, addressing a critical public health gap as AD prevalence is projected to triple to 13 million cases in the...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded Tufts University School of Medicine a $470,000 Project Grant under the Aging Research program (CFDA 93.866) on February 1, 2026, with a completion date of January 31, 2028. This grant funds research titled "Elucidating the Interplay Between AD Genetic Variants Using Human iPSC-Derived Brain Cells," which investigates the genetic mechanisms underlying Alzheimer's disease (AD). Given that AD has an estimated...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded Icahn School of Medicine at Mount Sinai a Project Grant totaling $839,933 under the Aging Research program (CFDA 93.866), effective September 1, 2025, through May 31, 2030. This award supports research investigating the role of N6-methyladenosine (M6A) RNA modifications in microglial dysfunction and Alzheimer's disease pathogenesis. The research will systematically map M6A RNA modification landscapes in microglia...
- Federal Grant Award Summary J. David Gladstone Institutes received a $1.46 million Project Grant from the National Institute on Aging under the Aging Research program (CFDA 93.866) to conduct research on inhibitory neuron dysfunction in Alzheimer's disease models. The award, effective August 1, 2025 through July 31, 2027, supports the development and implementation of innovative methodologies to monitor and manipulate parvalbumin (PVALB) and somatostatin (SST) inhibitory interneuron...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded The Trustees of Columbia University in the City of New York $852,273 through the Aging Research program (CFDA 93.866) to conduct a comprehensive genetic mapping study of RNA modifications in the aging human brain and their association with Alzheimer's disease (AD). This project grant, initiated September 1, 2025, with completion targeted for May 31, 2030, will deliver a multi-faceted research effort examining how genetic...
- Federal Project Grant Award Summary Duke University's Office of Research Administration received a $509,413 Project Grant award from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), effective September 15, 2025 through May 31, 2030. This award funds scientific research investigating epitranscriptomic regulation of microglia in Alzheimer's disease (AD), with the primary deliverable being novel research findings and analysis concerning how adenosine methylation...
New York University School of Medicine received a $642,063 Project Grant award from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), effective January 15, 2026, with completion targeted for December 31, 2030. The award supports a collaborative research investigation examining gabaergic microcircuits in the hippocampal CA1 region to identify cellular targets and neuromodulatory mechanisms for early-stage Alzheimer's disease (AD) therapeutics. The research will focus on vasoactive intestinal peptide (VIP+) and cholecystokinin (CCK+) inhibitory neurons that gate activity from the lateral entorhinal cortex, with the objective of developing targeted interventions that improve memory-guided behavior and entorhinal cortex-CA1 circuit dynamics in AD patients. The project deliverables include a cross-species comparison of gabaergic circuits in AD mouse models and human patients to assess pathological vulnerability and resilience across disease stages. This multidisciplinary effort, led by a neuroscientist specializing in cortico-hippocampal circuit function and a physician-scientist with expertise in early AD-related circuit dysfunction, is designed to generate translatable scientific findings and establish a framework for targeted therapeutic development. The research aligns with the NIA's mission to support biomedical and behavioral research directed toward preventing and treating Alzheimer's disease and related dementias through innovative basic and translational science approaches.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $642.1k | 1/14/26 |