Project Grant R56AG098971
- The National Institute on Aging awarded Icahn School of Medicine at Mount Sinai $230,388 on March 4, 2026, under the Aging Research program (CFDA 93.866) to dissect the role of the PICALM/EED locus on myeloid cells in Alzheimer's disease. The recipient will conduct research to understand how an Alzheimer's disease risk enhancer on chromosome 11 influences expression of two target genes—PICALM (phosphatidylinositol binding clathrin assembly protein) and EED (embryonic ectoderm development)—and to...
- The National Institute on Aging awarded Icahn School of Medicine at Mount Sinai $746,063 on September 1, 2026, under the Aging Research program (CFDA 93.866) to investigate amyloid beta plaque formation and neuroinflammation in aging people with HIV. The award funds exploration of cell-specific transcriptional changes associated with early amyloid beta deposition in human brain, distinguishing compacted amyloid with early neuritic pathology from diffuse amyloid without neuritic change, and...
- The National Institute on Aging awarded Icahn School of Medicine at Mount Sinai $2.944 million on June 1, 2026, under the Aging Research program (CFDA 93.866) to investigate systemic roles of apolipoprotein E (APOE) genotypes in central nervous system health and Alzheimer's disease pathology. The research uses plasma transfer and parabiosis models to examine how blood-borne factors and APOE genotype-specific mediators influence blood-central nervous system neuroimmune communication. The...
- The National Institute of Neurological Disorders and Stroke awarded Icahn School of Medicine at Mount Sinai $1,967,309 on September 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to dissect the role of small non-coding RNAs in microglia-driven neuroinflammation in Alzheimer's disease. The funded research will elucidate how small non-coding RNAs—including microRNA isoforms, transfer RNA-derived fragments, ribosomal RNA-derived...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded Icahn School of Medicine at Mount Sinai a Project Grant of $2,129,396 under the Aging Research program (CFDA 93.866) on August 1, 2025, with completion targeted for July 31, 2027. This research grant supports the development and validation of novel adeno-associated virus (AAV) constructs designed to enable gene knockdown in follicle-stimulating hormone receptor (FSHR)-positive neurons within Alzheimer's...
- The National Institute of Neurological Disorders and Stroke awarded Icahn School of Medicine at Mount Sinai $670,266 on January 20, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to map the epigenomic and spatial transcriptomic landscape in Parkinson's disease and Alzheimer's disease. The project characterizes shared and distinct transcriptional changes between Parkinson's disease, Alzheimer's disease, and Alzheimer's...
- The National Institute on Aging awarded The Research Foundation For The State University Of New York (operating as Stony Brook University) $454,937 on February 15, 2026, under the Aging Research program (CFDA 93.866) to investigate the regulatory landscape of neurodegeneration using single-cell spatial multiomics approaches. The research integrates chromatin accessibility and protein-level measurements to characterize how cells near Alzheimer's disease hallmarks—amyloid-beta and tau—regulate...
- The National Institute on Aging awarded Icahn School of Medicine at Mount Sinai $1,025,931 on September 20, 2025, under the Aging Research program (CFDA 93.866) to develop and implement the Postbaccalaureate Alzheimer's Disease Development Initiative (PADDI), a two-year comprehensive training program targeting ethnic and racial diversity in Alzheimer's disease and related disorders research. PADDI trains postbaccalaureate researchers in the design, implementation, and ethical conduct of...
- Federal Grant Award Summary The National Institute on Aging awarded Icahn School of Medicine at Mount Sinai a $3.55 million Project Grant under the Aging Research program (CFDA 93.866) effective September 1, 2025, through August 31, 2029. The grant supports research investigating the relationship between individual vulnerability to stress and the development of neuropsychiatric symptoms (NPS) associated with Alzheimer's Disease (AD). The primary research deliverable involves studying how...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded Icahn School of Medicine at Mount Sinai a Project Grant of $463,916 under the Aging Research program (CFDA 93.866) for the period September 1, 2025 through August 31, 2027. The award funds research to identify and characterize the "ankosome," a newly discovered cytoplasmic activation platform for caspase-2 (C2) that assembles in response to cytoskeletal injury. This exploratory research (R21 mechanism)...
The National Institute on Aging awarded Icahn School of Medicine at Mount Sinai $704,145 on September 1, 2026, under the Aging Research program (CFDA 93.866) to develop and apply computational methods for inferring the natural history of Alzheimer's disease from sparse longitudinal molecular and neuroimaging data. The recipient will develop an innovative approach that leverages temporal signal in sparse longitudinal datasets to reconstruct the timeline of Alzheimer's disease progression and validate its accuracy. The work applies this methodology to molecular and neuroimaging data from the Alzheimer's Disease Neuroimaging Initiative (ADNI), Alzheimer Biomarkers Consortium–Down Syndrome (ABC-DS), and Standardized Centralized Alzheimer's & Related Dementias Neuroimaging (SCAN) to reconstruct, replicate, and validate clinically and genetically inferred Alzheimer's timelines. Using these reconstructed timelines, the recipient identifies accessible plasma and imaging biomarkers that mark key disease stages and actionable therapeutic windows. The work further projects blood and brain samples from the Religious Orders Study/Memory and Aging Project (ROSMAP) onto the inferred Alzheimer's timelines and integrates these projections with ROSMAP's deep molecular data to delineate the dynamic molecular etiology of Alzheimer's disease and construct stage-specific biological coexpression networks. Performance occurs at Mount Sinai's location in New York, New York 10029. The period of performance runs from September 1, 2026, through August 31, 2027. The award is classified as a Project Grant, an assistance type supporting targeted biomedical research and research training.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $704.1k | 8/14/26 |