Project Grant R01AG090585
- Federal Grant Award Summary The Broad Institute of MIT and Harvard received a $1.22 million Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), effective September 1, 2025, through May 31, 2030. The award supports research on genetic dissection of mitonuclear interactions in aging and neurodegenerative disease. The research leverages two novel technological platforms developed by the investigative team: mitochondrial DNA (mtDNA) editing...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded Massachusetts General Hospital a $463,000 Project Grant effective May 1, 2026, through January 31, 2031, under the Aging Research program (CFDA 93.866). This research initiative focuses on understanding the chromatin mechanisms of cytoplasmic chromatin fragments (CCF) that accumulate during cellular senescence and aging. The primary deliverable is scientific research investigating how CCF are generated, their genetic...
- Federal Project Grant Award Summary Massachusetts Institute of Technology received a $466,340 project grant from the National Institute on Aging under the Aging Research program (CFDA 93.866) for the period February 1, 2026 through January 31, 2028. The award supports the development and pilot testing of nucleic acid nanoparticles (NANPs), a novel non-viral vector technology designed to deliver therapeutic nucleic acids—including short interfering ribonucleic acids (siRNAs), antisense...
- Federal Project Grant Award Summary Boston University Medical Campus received a $343,350 Project Grant from the National Institute on Aging (Aging Research program, CFDA 93.866) awarded May 1, 2026, with a completion date of March 31, 2031. The grant funds biomedical research investigating the role of endogenous RNA interference (RNAi) mechanisms in aging control and lifespan extension. The research utilizes Caenorhabditis elegans as a model organism to examine how small RNAs (sRNAs) and...
- Federal Grant Award Summary The National Institute on Aging (NIA), under the Aging Research program (CFDA 93.866), awarded the University of Virginia a Project Grant of $1,044,334 effective August 1, 2025, through May 31, 2030. This research award supports investigation into the mechanisms of ribosomal DNA (rDNA) instability during aging, with the goal of understanding how genomic instability—a hallmark of aging conserved across species—contributes to cellular aging processes. The project will...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded Massachusetts General Hospital $157,760 on August 20, 2026, under the Aging Research program (CFDA 93.866) to investigate a novel mechanism of autophagic degradation in cellular senescence. The research project, with a completion date of August 19, 2027, will examine how autophagy—a cellular self-digestion process—functions differently in senescent cells compared to other cellular states. Specifically, the...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded Massachusetts General Hospital $269,452 on February 18, 2026, under the Aging Research program (CFDA 93.866) to conduct research on proteomic aging and frailty prediction. The project, entitled "Deciphering Proteomic Aging: From Causal Mechanisms to Frailty Prediction," will integrate large-scale genetic, multi-omic, and clinical data from four major biobanks—the UK Biobank, Multi-Ethnic Study of...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded a Project Grant of $781,008 to Boston University (Trustees of Boston University, doing business as Boston University Medical Campus) on September 15, 2025, under the Aging Research program (CFDA 93.866). The award supports a research project titled "tRNA Modifications Regulating Mitochondrial Function and the Mitochondrial Proteome in AD/ADRD," with a completion date of June 30, 2030. The project...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded a Project Grant totaling $132,705.00 on June 15, 2025, to The Children's Hospital Corporation (Boston Children's Hospital) under the Aging Research program (CFDA 93.866). This award supports research addressing hematopoietic clonal dominance during aging—a condition in which driver mutations cause a limited number of hematopoietic stem and progenitor cell (HSPC) clones to disproportionately contribute to blood cell...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded the University of Massachusetts Medical School a Project Grant of $452,783 under the Aging Research program (CFDA 93.866) to conduct biomedical research on molecular mechanisms of neuronal cell death and neurodegeneration. The award, effective June 1, 2026 through May 31, 2028, supports investigation into context-specific molecular pathways that protect against age-related neurodegeneration and axon degeneration. The...
The National Institute on Aging (NIA) awarded Massachusetts Institute of Technology (MIT) a Project Grant of $723,962 under the Aging Research program (CFDA 93.866) effective June 1, 2026 through February 28, 2031. This award funds a systems-level research initiative examining the interplay between DNA adducts, DNA repair mechanisms, and cellular aging processes. The research employs advanced mass spectrometric "adductomics" technologies and in vivo host cell reactivation (FM-HCR) assays to define the comprehensive spectrum of DNA lesions in human cells and identify how these lesions accumulate in senescing cells to drive replication stress and cellular aging. The project utilizes a library of DNA repair gene knockouts developed in retinal epithelial and fibroblast cell lines to assess how loss of base excision repair (BER) pathways contributes to senescence and aging phenotypes. The research deliverables include characterization of DNA adduct landscapes under normal and environmental exposure conditions, identification of DNA repair pathways for key adduct subsets, and mechanistic understanding of how impaired DNA repair drives cell senescence and aging-related phenotypes. This interdisciplinary collaboration addresses fundamental gaps in knowledge regarding the actual substrates of DNA repair enzymes in vivo and the causal relationship between defective DNA repair and human diseases such as premature aging and neurodegeneration, thereby contributing to the NIA's mission of understanding the aging process and age-related diseases.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $724.0k | 5/27/26 |