Project Grant R01AG086451
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded Boston Children's Hospital $1.87 million through the Aging Research program (CFDA 93.866) to conduct a four-year research project (August 2025 – July 2029) investigating the genetics of exceptional longevity and cellular resilience mechanisms. The primary deliverable is scientific research examining the genome of the ocean quahog (Arctica islandica), the world's longest-lived animal with documented lifespans...
- Federal Grant Award Summary Boston University Medical Campus received a $1,224,405 Project Grant from the National Institute on Aging (CFDA 93.866 – Aging Research program) awarded August 1, 2025, with completion scheduled for April 30, 2030. This award supports multiscale modeling and empirical studies investigating the mechanisms underlying normal and pathological brain aging. The research combines computational neuroscience models with empirical studies in rhesus monkey dorsolateral...
- Federal Grant Award Summary Boston University Medical Campus received a $686,700 Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), awarded August 15, 2025, with completion by July 31, 2027. This grant supports a two-phase research initiative investigating chronic wound stress as a catalyst for systemic aging and functional decline. The project will establish and validate a mouse model simulating chronic wound stress across different adult...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded the University of Massachusetts Medical School a Project Grant totaling $452,783 (Award Date: June 1, 2026; Completion Date: May 31, 2028) under the Aging Research program (CFDA 93.866) to conduct biomedical research on the molecular mechanisms of neuronal cell death and neurodegeneration. The primary research deliverables include investigation of how context-specific molecular pathways protect against age-related...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded Boston University a $781,008 Project Grant (CFDA 93.866, Aging Research program) effective September 15, 2025, through June 30, 2030, to investigate tRNA (transfer RNA) modifications regulating mitochondrial function in Alzheimer's disease and related dementias (AD/ADRD). The research aims to identify genetic mutations in mitochondrial DNA, tRNA genes, and genes encoding the mitochondrial proteome associated with AD status...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded Boston University Medical Campus a Project Grant of $1.7M under the Aging Research program (CFDA 93.866) on September 15, 2025, to investigate tRNA (transfer RNA) epitranscriptome dysregulation and translational dysfunction in Alzheimer's disease and related dementias (ADRD). The research examines how modifications to the ~250 different tRNA molecules in the human body become dysregulated in neurodegenerative disease, with...
- Federal Grant Award Summary The National Institute on Aging awarded The Washington University a Project Grant in the amount of $556,121 under the Aging Research program (CFDA 93.866) on January 15, 2026. The award supports research through December 31, 2030, conducted at the university's St. Louis, Missouri facility. The project investigates transgenerational epigenetic adaptation and longevity changes in response to repeated environmental stresses, utilizing Caenorhabditis elegans (C....
- Federal Grant Award Summary The National Institute on Aging awarded a Project Grant of $157,760 to The General Hospital Corporation (Massachusetts General Hospital) effective August 20, 2026, through August 19, 2027, under the Aging Research program (CFDA 93.866). This research project investigates a novel mechanism of autophagic degradation in cellular senescence, specifically examining how ATG8 (autophagy-related protein 8) family proteins facilitate protein degradation through covalent...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded a Project Grant totaling $132,705.00 on June 15, 2025, to The Children's Hospital Corporation (Boston Children's Hospital) under the Aging Research program (CFDA 93.866). This award supports research addressing hematopoietic clonal dominance during aging—a condition in which driver mutations cause a limited number of hematopoietic stem and progenitor cell (HSPC) clones to disproportionately contribute to blood cell...
- Federal Project Grant Award Summary The University of Virginia received a $522,167 Project Grant from the National Institute on Aging (Aging Research program, CFDA 93.866) awarded August 1, 2025, with a completion date of May 31, 2030. This research project investigates the mechanisms of ribosomal DNA (rDNA) instability during aging, with a focus on understanding how DNA double-strand breaks and genomic instability contribute to cellular aging. The research examines the roles of FOB1 and its...
Grant Award Summary The National Institute on Aging (NIA) awarded Trustees of Boston University a $343,350 Project Grant effective May 1, 2026, through March 31, 2031, under the Aging Research program (CFDA 93.866). This research project investigates the mechanisms by which endogenous double-stranded RNA (dsRNA)-derived small RNAs regulate lifespan extension, with particular focus on major sperm protein (MSP) genes and their role in modulating insulin/insulin-like growth factor-1 signaling pathways. The research employs the model organism Caenorhabditis elegans to elucidate how small RNA and argonaute protein-mediated gene repression in the spermatogenic germline contributes to extended lifespan, potentially revealing conserved aging pathways applicable to mammalian biology. The scientific deliverables include gene expression analyses, lifespan extension studies, and mechanistic investigations of the VAB-1 ephrin receptor pathway and its interaction with DAF-18/PTEN signaling. Boston University Medical Campus will conduct this research at its Roxbury, Massachusetts facility, leveraging the institution's substantial expertise in biomedical research and established track record of federal funding across the NIH portfolio. The project outcomes are intended to advance fundamental understanding of aging processes and identify potential therapeutic targets for age-related diseases.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $343.4k | 4/30/26 |