Project Grant R21AG099044
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded Icahn School of Medicine at Mount Sinai a $835,417 Project Grant effective June 1, 2025, through March 31, 2030, under the Aging Research program (CFDA 93.866). The award supports the development and evaluation of novel lipid nanoparticle (LNP) formulations designed to deliver nucleic acid therapeutics across the blood-brain barrier for treatment of Alzheimer's disease. Key deliverables include the synthesis of...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded the Broad Institute of MIT and Harvard a Project Grant of $610,836 under the Aging Research program (CFDA 93.866) for the period September 1, 2025 through May 31, 2030. This award supports research on genetic dissection of mitonuclear interactions in aging and neurodegenerative disease. The research will leverage two technological advances—mitochondrial DNA (mtDNA) editing using DDCBE base editors and biobank-scale...
- Federal Project Grant Award Summary Boston University Medical Campus received a $147,486 Project Grant from the National Institute on Aging under the Aging Research program (CFDA 93.866), awarded February 19, 2025, with completion scheduled for November 7, 2026. This award supports functional epitranscriptomic profiling research investigating N6-methyladenosine (m6A) RNA modifications in Alzheimer's disease. The research deliverables include identification of m6A-modified RNA sites and...
- Federal Grant Award Summary Harvard Medical School received a $125,901 Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), awarded August 15, 2025, with a completion date of May 31, 2027. The grant supports research investigating cell-type-specific dysregulation and genetic control of alternative polyadenylation (APA) in neurodegenerative disease, specifically Alzheimer's disease and Parkinson's disease. The research delivers novel...
- Federal Project Grant Award Summary The University of Massachusetts Medical School received a $445,130 Project Grant award from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), effective January 1, 2026 through December 31, 2030. This research project focuses on elucidating the mechanisms by which Membrane Spanning 4A (MS4A) genes regulate neurodegeneration in Alzheimer's disease and related neurodegenerative disorders, including frontotemporal dementia,...
- Federal Project Grant Award Summary Boston University Medical Campus received $781,008 in project grant funding from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), with an award date of September 15, 2025 and completion date of June 30, 2030. The grant supports basic scientific research investigating the relationship between transfer RNA (tRNA) modifications and mitochondrial dysfunction in Alzheimer's disease and related dementias (AD/ADRD). The research...
- Federal Project Grant Award Summary Northeastern University received a $2.24 million project grant from the National Institute on Aging under the Aging Research program (CFDA 93.866), awarded May 15, 2025, with completion targeted for February 28, 2030. The award funds comprehensive proteogenomic profiling research to characterize aberrant and mis-processed proteins in Alzheimer's disease (AD) and tauopathy models. The research integrates genomic, transcriptomic, and proteomic data through a...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded Tufts University School of Medicine a $470,000 Project Grant under the Aging Research program (CFDA 93.866) on February 1, 2026, with a completion date of January 31, 2028. This grant funds research titled "Elucidating the Interplay Between AD Genetic Variants Using Human iPSC-Derived Brain Cells," which investigates the genetic mechanisms underlying Alzheimer's disease (AD). Given that AD has an estimated...
- Federal Project Grant Award Summary Boston University Medical Campus received a $636,342 Project Grant award from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), effective August 1, 2025 through April 30, 2030. This award supports multiscale modeling and empirical studies investigating normal and pathological brain aging, specifically examining myelin dystrophy, synaptic loss, and neuronal hyperexcitability in the neocortex as common hallmark changes in both...
- Federal Grant Award Summary The University of Massachusetts Medical School received a $3.32 million Project Grant from the National Institute on Aging (Aging Research program, CFDA 93.866) awarded on August 15, 2025, with a completion date of July 31, 2029. This award supports collaborative research by the Bosco and Massi laboratories investigating the role of profilin-1 (PFN1) mutations in amyotrophic lateral sclerosis (ALS) pathogenesis. The research employs multiple investigative models,...
Massachusetts Institute of Technology received a $466,340 Project Grant from the National Institute on Aging under the Aging Research program (CFDA 93.866), awarded February 1, 2026, with completion targeted for January 31, 2028. This award supports the development and pilot testing of nucleic acid nanoparticles (NANPs), a novel non-viral vector technology designed to deliver therapeutic nucleic acids—including short interfering RNAs (siRNAs), antisense oligonucleotides (ASOs), and messenger RNAs (mRNAs)—to specific regions and cell types within the central nervous system. The research addresses a critical gap in treatment options for Alzheimer's disease and related neurodegenerative disorders by utilizing intrathecal administration to bypass blood-brain barrier delivery challenges that have limited previous therapeutic approaches. The project deliverables focus on developing NANP formulations capable of targeted central nervous system distribution following intrathecal administration, with the goal of enabling safe, effective, and repeated dosing of therapeutic nucleic acid therapies. The technology seeks to advance treatment capabilities for Alzheimer's disease and other neurological conditions by overcoming manufacturing scalability challenges and achieving cell-type specificity within brain tissue—objectives aligned with the National Institute on Aging's mission to support research advancing prevention and treatment of age-related diseases and dementias.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $466.3k | 1/21/26 |