Project Grant R01AG094861
- Federal Grant Award Summary The National Institute on Aging awarded a Project Grant of $157,760 to The General Hospital Corporation (Massachusetts General Hospital) effective August 20, 2026, through August 19, 2027, under the Aging Research program (CFDA 93.866). This research project investigates a novel mechanism of autophagic degradation in cellular senescence, specifically examining how ATG8 (autophagy-related protein 8) family proteins facilitate protein degradation through covalent...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded a Project Grant totaling $132,705.00 on June 15, 2025, to The Children's Hospital Corporation (Boston Children's Hospital) under the Aging Research program (CFDA 93.866). This award supports research addressing hematopoietic clonal dominance during aging—a condition in which driver mutations cause a limited number of hematopoietic stem and progenitor cell (HSPC) clones to disproportionately contribute to blood cell...
- Federal Project Grant Award Summary Massachusetts General Hospital received a $269,452 Project Grant from the National Institute on Aging (Aging Research program, CFDA 93.866) awarded February 18, 2026, with completion targeted for November 30, 2028. The grant supports research titled "Deciphering Proteomic Aging: From Causal Mechanisms to Frailty Prediction," which aims to identify causal protein drivers of age-related diseases and develop predictive clinical tools. The research...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded J. David Gladstone Institutes a Project Grant totaling $1,587,554 under the Aging Research program (CFDA 93.866) to conduct biomedical research investigating mitochondrial deoxyribonucleic acid (mtDNA) compaction and its relationship to somatic mutation accumulation across the human lifespan. The research project, initiated on June 17, 2025, and scheduled for completion by April 30, 2030, will deliver scientific...
- Federal Grant Award Summary The National Institute on Aging awarded the University of Pennsylvania a $2.8 million Project Grant under the Aging Research program (CFDA 93.866) for the five-year period from February 1, 2026, through January 31, 2031. The grant supports research on the epigenetics of aging and age-associated diseases, with particular focus on two mechanisms: chromostasis (homeostatic mechanisms that maintain dynamic chromatin stability) and the senescence-associated secretory...
- Federal Project Grant Award Summary The National Institute on Aging (part of the Aging Research program, CFDA 93.866) awarded a $397,416 Project Grant to the University of Massachusetts Medical School on September 4, 2025, with a completion date of May 31, 2027. Under the direction of Principal Investigator Dr. Zintis Inde, this award funds research investigating apoptotic dysregulation across cell types in aging and neurodegeneration, with specific focus on understanding how programmed cell...
- Federal Grant Award Summary The Broad Institute of MIT and Harvard received a $610,836 Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866) effective September 1, 2025, through May 31, 2030. This award supports research on the genetic dissection of mitochondrial-nuclear (mitonuclear) interactions in aging and neurodegenerative disease, with particular focus on Alzheimer's disease and related dementias (ADRD). The research leverages two key...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded the University of Colorado-Denver $547,371 on May 1, 2026, under the Aging Research program (CFDA 93.866) to support a five-year research project extending through January 31, 2031. The project focuses on investigating telomere entanglements—persistent DNA bridges that form when replication forks stall at dysfunctional telomeres—and their impact on genome stability. The research will examine the molecular...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded Massachusetts General Hospital a $629,562 Project Grant on August 15, 2025, under the Aging Research program (CFDA 93.866) to investigate the role of mechanical stiffening of the intestine in age-related decline of intestinal health and function. The research project, scheduled for completion on July 31, 2030, will deliver scientific research and analysis examining how aging-associated mechanical changes in intestinal...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded the University of Massachusetts Medical School a Project Grant totaling $452,783 (Award Date: June 1, 2026; Completion Date: May 31, 2028) under the Aging Research program (CFDA 93.866) to conduct biomedical research on the molecular mechanisms of neuronal cell death and neurodegeneration. The primary research deliverables include investigation of how context-specific molecular pathways protect against age-related...
The National Institute on Aging (NIA) awarded Massachusetts General Hospital a $463,000 Project Grant effective May 1, 2026, through January 31, 2031, under the Aging Research program (CFDA 93.866). This research project investigates the chromatin mechanisms underlying cytoplasmic chromatin fragments (CCF) formation during cellular senescence and aging. The research will employ cGAS (cyclic GMP-AMP synthase) immunoprecipitation followed by unbiased sequencing to identify the genetic origins and composition of CCF and their role in activating chronic inflammation pathways. Preliminary findings indicate that CCF in senescent cells are enriched in H3K27ME3 (tri-methylation of lysine 27 on histone H3), a heterochromatic mark associated with gene repression, with the research team investigating the functional role of the chromatin reader protein CBX8 in this process. This project advances understanding of senescence and aging-associated inflammation by clarifying the genetic identity and derivation of CCF—knowledge critical to understanding how cellular senescence contributes to age-related pathologies. The research builds upon the investigator group's prior contributions establishing that the CCF-cGAS-STING pathway represents a central mechanism in chronic inflammation during senescence and aging, findings that have been independently validated by other research groups. The study will generate scientific insights into the genetic alterations occurring during aging and the origins of chronic inflammation, supporting the NIA's mission to understand aging processes and age-related diseases.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $463.0k | 4/29/26 |