Project Grant R21AG093537
- Federal Project Grant Award Summary The National Institute on Aging (part of the Aging Research program, CFDA 93.866) awarded a $397,416 Project Grant to the University of Massachusetts Medical School on September 4, 2025, with a completion date of May 31, 2027. Under the direction of Principal Investigator Dr. Zintis Inde, this award funds research investigating apoptotic dysregulation across cell types in aging and neurodegeneration, with specific focus on understanding how programmed cell...
- Federal Grant Award Summary The University of Massachusetts Medical School received a $445,130 project grant awarded January 1, 2026, through December 31, 2030, from the National Institute on Aging under the Aging Research program (CFDA 93.866). This award funds research investigating the mechanisms by which MS4A (membrane spanning 4A) genes regulate neurodegeneration in Alzheimer's disease and related disorders, including frontotemporal dementia, multiple sclerosis, and amyotrophic lateral...
- Federal Project Grant Summary The National Institute on Aging (NIA) awarded University of Massachusetts Medical School $3.32M through the Aging Research program (CFDA 93.866) on August 15, 2025, for a four-year research project concluding July 31, 2029. The award supports collaborative research by the Bosco and Massi laboratories investigating the molecular mechanisms underlying profilin-1 (PFN1)-mediated amyotrophic lateral sclerosis (ALS), a uniformly lethal neurodegenerative disease. The...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded The Salk Institute for Biological Studies a Project Grant of $620,441 under the Aging Research program (CFDA 93.866), with an award date of February 15, 2026 and ultimate completion date of January 31, 2031. This research initiative focuses on characterizing activity-dependent changes to neuronal populations in the spinal dorsal horn during aging and determining the functional consequences of dorsal horn remodeling for...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded the University of Massachusetts Medical School $643,089 under the Aging Research program (CFDA 93.866) for a project grant beginning September 30, 2025, and concluding August 31, 2026. The project, titled "Medication Self-Administration (MSA) and Awareness of MSA: Life-Relevant Markers of Cognitive Impairment," will conduct objective assessments of medication self-administration capability as an early indicator...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded the University of South Florida $3.297 million under the Aging Research program (CFDA 93.866) for a four-year project period (September 1, 2025 – August 31, 2029) to develop novel peptidomimetic biomaterials that inhibit amyloid-beta (Aβ42) aggregation in Alzheimer's disease. The research deliverables include the rational design and characterization of structurally related analogues to a lead compound that stabilizes Aβ...
- Federal Grant Award Summary Boston University Medical Campus received a $1,224,405 Project Grant from the National Institute on Aging (CFDA 93.866 – Aging Research program) awarded August 1, 2025, with completion scheduled for April 30, 2030. This award supports multiscale modeling and empirical studies investigating the mechanisms underlying normal and pathological brain aging. The research combines computational neuroscience models with empirical studies in rhesus monkey dorsolateral...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded University of Maryland, Baltimore a Project Grant of $649,766 under the Aging Research program (CFDA 93.866) effective March 1, 2026, with a completion date of January 31, 2031. This research project investigates the role of hyperpolarization-activated cyclic nucleotide-gated (HCN) cation channels in olfactory dysfunction associated with aging and neurological diseases, particularly Alzheimer's disease. The project...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded Boston Children's Hospital a Project Grant of $167,940 on August 15, 2025, under the Aging Research program (CFDA 93.866) to investigate the neuronal mechanisms underlying cognitive resilience to Alzheimer's disease (AD). The research project, which will be completed by May 31, 2030, aims to elucidate how MEF2 transcription factors (MEF2A and MEF2C) promote neuronal survival and cognitive resilience in individuals with...
- Federal Grant Award Summary The National Institute on Aging awarded Rutgers, The State University a $909,876 Project Grant on August 15, 2025, under the Aging Research program (CFDA 93.866) to investigate the molecular mechanisms by which exercise protects the aging nervous system. The research utilizes Caenorhabditis elegans (C. elegans) as a model organism to understand how regular physical activity extends longevity, maintains nervous system functionality in aging, and provides...
The National Institute on Aging (NIA) awarded the University of Massachusetts Medical School a Project Grant totaling $452,783 (Award Date: June 1, 2026; Completion Date: May 31, 2028) under the Aging Research program (CFDA 93.866) to conduct biomedical research on the molecular mechanisms of neuronal cell death and neurodegeneration. The primary research deliverables include investigation of how context-specific molecular pathways protect against age-related neurodegeneration, with specific focus on determining the protective mechanisms of TIR-1/SARM1 (a conserved axon degeneration regulator) against excitotoxicity and oxidative stress-induced neuronal damage, as well as characterization of mutations identified through forward genetic screening that suppress neurotoxicity in aged organisms. The research employs Caenorhabditis elegans models of age-related neurotoxicity, including models induced by ionotropic acetylcholine receptor overexpression and paraquat-induced oxidative stress, to generate scientific knowledge regarding conserved molecular pathways relevant to Alzheimer's disease and neurodegeneration. The anticipated products include peer-reviewed scientific findings that identify novel therapeutic targets and mechanisms for preventing neuronal decline, with potential applications to inform therapeutic development for neurodegenerative diseases in human populations.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $452.8k | 5/18/26 |