The National Institute on Aging (NIA) awarded a $673,650 Project Grant under the Aging Research program (CFDA 93.866) to the Mayo Clinic in Rochester, Minnesota. The objective of this 5-year grant is to evaluate the hypothesis that inflamed adipose tissue contributes to blunted exercise response and muscle dysfunction in older adults. Key activities include in vivo imaging and molecular phenotyping of abdominal and intermuscular adipose tissue, as well as cell culture experiments using muscle...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $1,545,208 to the Florida Institute for Human & Machine Cognition (IHMC) to conduct a 5-year research study on exercise response heterogeneity in older adults. The project aims to understand the mechanisms driving variability in older adults' responses to combined endurance and resistance training, with a focus on factors related to aging hallmarks like proteostasis, mitochondrial...
The National Institute on Aging (NIA), under the Aging Research federal grant program (CFDA 93.866), awarded a $3,161,352 project grant (R01AG089069) to the University of Colorado-Denver. The 5-year grant, beginning on August 15, 2024, will fund a randomized controlled trial to investigate the molecular mechanisms underlying the heterogeneous effects of aerobic exercise training on peripheral and cerebrovascular function in adults of different ages and sexes. Key research activities include...
This $485,375 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will fund research at the University of Washington to investigate genomic alterations in skeletal muscle associated with aging. The key objectives are to: Explore if alternative splicing of mRNA results in quantitative differential isoform changes associated with aging, potentially leading to increased expression of non-functional proteins relevant for healthy muscle function. The researchers...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will fund research to examine the role of the MYC gene in regulating skeletal muscle function, metabolism, and age-related changes. The $141,890 award to the University of Arkansas will support the development of mouse models to investigate how MYC induction and exercise impact muscle at the cellular and molecular levels, including DNA methylation "clock" age. The research aims to provide...
This federal Project Grant award of $2,358,537.00 from the National Institute on Aging (CFDA 93.866 - Aging Research) supports a research project titled "Epigenetic Aging, Cognitive Function and Exercise in Older Adults" at the University of Pittsburgh. The project aims to investigate the impact of exercise on epigenetic aging and its relationship to cognitive function, brain health, and Alzheimer's disease biomarkers in non-cognitively impaired older adults. The award period runs from...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $649,679 to the Regents of the University of Minnesota to conduct research on mechanisms of aging. The project aims to evaluate how a population of mouse T cells can be iteratively boosted and passaged among young mice for over 11 years, exceeding the normal mouse lifespan, while retaining functional competence and proliferative potential. The research will investigate factors such as...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $133,353.00 to Mayo Clinic to conduct research on the molecular mechanisms of T cell-mediated surveillance of senescent cells under both physiological and aging conditions. The primary objectives are to: 1) Define how various types of senescent cells deploy their secretome to sensitize human T cells toward activation, survival, and retention; 2) Assess co-stimulatory and co-inhibitory...
This Project Grant from the National Institutes of Health's National Institute on Aging, under the Aging Research program (CFDA 93.866), provides $287,218.16 in funding to the University of Maryland, Baltimore from August 1, 2021 through March 27, 2022. The award supports research aimed at better understanding the impact of aging on muscle excitability and action potential conduction velocity. Specifically, the recipient will use electrophysiology techniques and optical imaging to examine...
This $485,375 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will support the development and evaluation of a 3D engineered muscle tissue model to study the metabolic response to muscle contraction in the context of aging. The University of Washington, a prominent research institution, will lead this 2-year project to: 1) examine the mitochondrial mechanisms underlying the decreased metabolic response to muscle contraction in aged human 3D engineered...
This federal Project Grant award from the National Institute on Aging (NIA), under the Aging Research program (CFDA 93.866), provides $1,294,013 to Mayo Clinic to conduct a randomized clinical trial examining the impact of biological mechanisms of aging on exercise response variability in older adults. The project aims to define the heterogeneity in physical function and insulin sensitivity outcomes in response to a 6-month resistance training intervention, with a focus on investigating the roles of cellular senescence and epigenetics. The research will involve state-of-the-art molecular profiling of skeletal muscle and blood-based biomarkers, as well as predictive analyses to understand how these biological mechanisms, clinical factors, and behavioral variables mediate the variable exercise responses. The award period is from September 1, 2024, to August 31, 2029. Sub-awards have been made to Tufts Medical Center and Tufts University School of Medicine to support various aspects of the research study.