Project Grant K02AG088465

Award Date 6/1/25
Completion Date 7/31/30
Dollars Obligated $142K
Federal Grant Program
93.866
Assistance Type
Project Grant
Place of Performance
Arkansas, USA
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The National Institute on Aging (NIA) awarded a $485,375 Project Grant (CFDA 93.866 - Aging Research) to the University of Washington (UW) to investigate genomic alterations in skeletal muscle associated with aging. The 2-year project (Aug 1, 2024 - Jul 31, 2026) aims to discover mechanisms underlying age-related decline in muscle function. Specifically, the research will: Explore if alternative splicing of mRNA results in quantitative differential isoform changes associated with aging,...
The National Institute on Aging (NIA) awarded a 5-year, $1,294,013 Project Grant (CFDA 93.866 - Aging Research) to Mayo Clinic to study the impact of biological mechanisms of aging on response variability to resistance training in older adults. The research will conduct a randomized clinical trial to define the exercise response heterogeneity in physical function and insulin sensitivity, examining cellular senescence and DNA methylation in skeletal muscle. The project involves collaboration with...
The National Institute on Aging (NIA) awarded a $1,545,208 Project Grant under the Aging Research federal grant program (CFDA 93.866) to the Florida Institute for Human & Machine Cognition Inc. (IHMC). The award, effective September 15, 2024 through August 31, 2029, will fund a multidimensional study to understand the factors contributing to exercise response heterogeneity in older adults. Specifically, the research will investigate how aging hallmarks such as proteostasis, mitochondrial...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) supports research on the effects of aging on the function of the muscle protein myosin and its chaperone UNC-45. The $576,893 award, effective September 15, 2024 through May 31, 2029, aims to investigate how age-related post-translational modifications of these proteins contribute to the loss of muscle mass and function, known as sarcopenia, in older adults. The research team, led by the University...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) for $673,650 aims to evaluate the hypothesis that inflamed adipose tissue contributes to blunted exercise response in skeletal muscle of older adults. The research objectives are to: Determine how adipose tissue influences skeletal muscle function and anabolic response to exercise in older adults using in vivo imaging and molecular phenotyping. Identify the molecular pathways by which abdominal...
This Project Grant award from the National Institute on Aging's Aging Research program (CFDA 93.866) provides $126,042 to the University of Southern California (USC) to investigate the role of mitochondrial proline catabolism, specifically the ALH-6 gene, in muscle-mitochondrial health and its impact on organismal longevity. The project aims to employ innovative techniques, including CRISPR/Cas9-mediated tissue-specific rescues, single-cell RNA sequencing, and mitochondrial assessments, to...
This Project Grant from the National Institutes of Health's National Institute on Aging, under the Aging Research program (CFDA 93.866), provides $287,218.16 in funding to the University of Maryland, Baltimore from August 1, 2021 through March 27, 2022. The award supports research aimed at better understanding the impact of aging on muscle excitability and action potential conduction velocity. Specifically, the recipient will use electrophysiology techniques and optical imaging to examine...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $572,203 to the Regents of the University of Michigan for a 5-year research project to investigate the role of Schwann cells in preserving muscle function and preventing sarcopenia (age-related muscle loss). The key objectives are to: (I) determine how the number and function of different Schwann cell populations change with aging and denervation, (II) analyze the expression patterns of the SPP1...
This $161,922 Project Grant award, funded by the National Institute on Aging's Aging Research program (CFDA 93.866), supports research investigating the mechanisms by which mitochondrial protein import stress can induce myokine signaling and the impact on metabolic and cardiovascular health, particularly during aging. The research, conducted by The Research Foundation for The State University of New York, Upstate Medical Center, aims to uncover the underlying processes by which mitochondrial...
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The National Institute on Aging (NIA) awarded a 5-year, $141,890 Project Grant (CFDA 93.866 - Aging Research) to the University of Arkansas to examine the role of the MYC gene in regulating skeletal muscle function, metabolism, and aging throughout the lifespan. The project aims to determine if MYC induction can mimic the effects of exercise and amplify the benefits of exercise training, as well as reverse age-related molecular and cellular changes in muscle. Key research activities include functional, bioenergetic, and cellular analyses, single-cell RNA sequencing, and global DNA methylation studies in muscle fibers under conditions of MYC induction and exercise. The findings are expected to provide fundamental insights into mechanisms underlying skeletal muscle mass regulation and the age-defying effects of exercise, potentially enabling new directions for improving healthspan.

Generated 6/17/25, 3:17 AM