The National Institute on Aging (NIA) awarded a 5-year, $1,294,013 Project Grant (CFDA 93.866 - Aging Research) to Mayo Clinic to study the impact of biological mechanisms of aging on response variability to resistance training in older adults. The research will conduct a randomized clinical trial to define the exercise response heterogeneity in physical function and insulin sensitivity, examining cellular senescence and DNA methylation in skeletal muscle. The project involves collaboration with...
This $485,375 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will support the development and testing of a 3D engineered muscle tissue model to study the metabolic response to muscle contraction in the context of aging. The University of Washington, a major research institution, will lead this effort in partnership with the Study of Muscle, Mobility and Aging research program (R01 AG059416). The project aims to 1) examine the mitochondrial mechanisms...
The National Institute on Aging (NIA) awarded a 5-year, $141,890 Project Grant (CFDA 93.866 - Aging Research) to the University of Arkansas to examine the role of the MYC gene in regulating skeletal muscle function, metabolism, and aging throughout the lifespan. The project aims to determine if MYC induction can mimic the effects of exercise and amplify the benefits of exercise training, as well as reverse age-related molecular and cellular changes in muscle. Key research activities include...
The National Institute on Aging (NIA) awarded a $1,545,208 Project Grant under the Aging Research federal grant program (CFDA 93.866) to the Florida Institute for Human & Machine Cognition Inc. (IHMC). The award, effective September 15, 2024 through August 31, 2029, will fund a multidimensional study to understand the factors contributing to exercise response heterogeneity in older adults. Specifically, the research will investigate how aging hallmarks such as proteostasis, mitochondrial...
This $143,874 federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), aims to identify mechanisms by which resistance exercise training (RET) enhances muscle insulin sensitivity. The award will support research at the Mayo Clinic to: 1) measure synthesis rates of individual muscle proteins in response to RET using stable isotope labeling in human...
This federal Project Grant award, totaling $153,512.00, was provided by the National Institute on Aging (CFDA 93.866 - Aging Research) to the Regents of the University of Minnesota. The grant will fund research to characterize the biochemistry and cellular signaling underlying cellular senescence induced by lipid aldehydes in adipose tissue. The proposed work aims to define mitochondrial protein targets of carbonylation during obesity and aging, and investigate the role of mitochondrial stress...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $159,512 to the University of Florida to conduct research on targeting muscle kynurenine aminotransferases and the aryl hydrocarbon receptor (AhR) pathway to mitigate age-related physical decline. The research aims to investigate if elevated levels of the metabolite L-kynurenine and increased AhR activity play a causal role in the decline of muscle and physical function with aging. The...
This Federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $195,896.00 to Wake Forest University Health Sciences to enhance an ongoing 12-month weight loss trial among older adults with obesity. The key products and services to be delivered include: Developing an automated image analysis platform to measure muscle quantity, quality, and changes over the 12-month trial using computed tomography (CT) scans. This will provide techniques to...
The National Institute on Aging has awarded a $1,473,241 Project Grant (CFDA 93.866) to Mayo Clinic to investigate the role of adipose senescent cells in cognitive function and Alzheimer's disease progression. The 5-year grant, awarded on August 15, 2024, will support research aimed at determining whether the accumulation of senescent cells in adipose tissue contributes to cognitive decline and neurodegeneration through endocrine effects. The project will utilize a novel mouse model to deplete...
This $820,142 federal Project Grant awarded by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under CFDA 93.846 "Arthritis, Musculoskeletal and Skin Diseases Research" will fund research to investigate the impact of early-life physical inactivity on adult muscle quality, function, and frailty development in mice. The primary objectives are to: 1) examine the effect of varying levels of early-life physical inactivity on muscle quality and function in...