This $1,545,208 federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will fund a multi-phase clinical trial study conducted by the Florida Institute for Human & Machine Cognition (IHMC). The study aims to understand the factors underlying the variability in exercise response among older adults, with a focus on evaluating the role of aging-related biological processes such as proteostasis, mitochondrial function, inflammation, and circadian...
This Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) supports research to optimize aerobic fitness and physical function in older adults through exercise interventions. The $625,835 award, with a project period from Jul 2024 to Jun 2029, will evaluate the efficacy of a combined high-intensity interval training (HIIT) and high-intensity resistance training (HIRT) regimen compared to standard moderate-intensity aerobic and resistance training. The goal is to...
This $2,358,537 federal Project Grant award from the National Institute on Aging's Aging Research program (CFDA 93.866) supports research to understand the impact of epigenetic aging on cognitive function and response to exercise in non-cognitively impaired older adults. The primary awardee, the University of Pittsburgh, will harness data and biospecimens from the Investigating Gains in Neurocognition in an Intervention Trial of Exercise (IGNITE) project to elucidate the biological underpinnings...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $639,997 to The Spaulding Rehabilitation Hospital Corporation to investigate how exercise regulates molecular cargo within circulating extracellular vesicles and impacts knee joint health in the context of knee osteoarthritis. The 5-year project, beginning in May 2025, aims to provide mechanistic insights into how exercise-induced molecular factors in the blood can promote cartilage...
This federal Project Grant award, provided by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), will fund research to investigate the role of endothelial signaling and reactive oxygen species (ROS) in determining the mitochondrial metabolic responses to exercise in skeletal muscle. The total funding amount is $354,200.00, with the award date of September 20, 2024, and a targeted...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $332,096 to The General Hospital Corporation (Massachusetts General Hospital) to evaluate the feasibility of non-invasive imaging techniques to monitor the metabolic and vascular functions of the brain and heart in a mouse model of Alzheimer's disease. The project aims to investigate the effects of moderate exercise on these key functions over time and whether there are any gender differences in...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $431,750 to Rutgers, The State University of New Jersey to identify molecular features associated with vascular alterations in aging. The project aims to isolate and characterize peptide ligands targeting vascular endothelial cells (VECs) in young versus aged mice, as well as senescent versus non-senescent murine VECs in vitro. The research seeks to enhance understanding of the molecular...
This federal Project Grant award, funded by the National Institute on Aging under the Aging Research program (CFDA 93.866), supports a $160,834 research study at Duke University to investigate the effects of exercise training on T cell function, metabolism, and aging in patients with rheumatoid arthritis (RA). The principal investigator plans to utilize data from a previous NIH-funded trial to determine if a remotely supervised caloric restriction and exercise training (CRET) program leads to...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $768,427 in funding to the University of Delaware to conduct a 3-year longitudinal study on the impact of midlife cerebrovascular pulsatility on brain tissue integrity and cognitive aging. The key objectives are to: (1) determine the early mechanisms leading to age-related increases in cerebrovascular pulsatility, (2) assess the spatial and temporal correlation between changes in...
This $715,500 federal Project Grant awarded by the National Science Foundation's (NSF) Engineering program will support research at the University of Illinois to investigate the relationship between exercise and cognitive health. The project aims to determine how muscle contraction during exercise may influence the activity and growth of cells in the hippocampus, the part of the brain involved in memory and learning. The research will conduct in vitro experiments culturing mouse muscle and...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $3,161,352 in funding to the University of Colorado-Denver to investigate the effects of aerobic exercise training on peripheral endothelial function and cerebrovascular function in adults of different ages and sexes. The 5-year research project will conduct a randomized controlled trial to assess changes in vascular function outcomes and analyze associated molecular biomarkers, including circulating exerkines and endothelial microvesicles. The goal is to better understand the heterogeneity in vascular adaptations to exercise across age and sex, which could inform personalized exercise recommendations and identify molecular targets for interventions to enhance the cardiovascular and cerebrovascular benefits of exercise, particularly in non-responders or those unable to exercise. The award commenced on August 15, 2024 and is scheduled for completion on July 31, 2029.