This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to the University of California, San Diego totals $651,793 and runs from July 15, 2024 to June 30, 2029. The grant supports research to investigate if young adult hematopoietic stem cells (HSCs) have elevated translation fidelity compared to progenitors and aged HSCs, and to determine if enhancing translation fidelity can increase HSC fitness and longevity. The project aims to develop a...
The National Institute on Aging (NIA) awarded a $614,625 Project Grant under the Aging Research federal grant program (CFDA 93.866) to the University of Oregon (UO) to develop a novel genome engineering system for comprehensive screening of mutations that increase longevity in the model organism Caenorhabditis elegans. The project aims to (1) create a library-based mutagenesis approach called "Transgenic Arrays Resulting in Diversity of Integrated Sequences" (TARDIS) that enables...
The National Institute on Aging (NIA), under the Aging Research Federal Grant Program (CFDA 93.866), awarded a $652,286 Project Grant to Northeastern University. The grant, titled "Genome-Wide CRISPR Activation: A Novel Strategy for Identifying Anti-Aging Targets," aims to systematically identify genes that modulate lifespan and health in the model organism C. elegans using advanced CRISPR activation technology. The research team, with expertise in aging genetics and high-throughput...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $506,404.00 to The Trustees of the University of Pennsylvania for a research project investigating the role of epigenetic mechanisms in aging and age-related diseases. The key objectives are to: (1) examine how changes in enhancer regulation and chromatin organization during senescence drive gene expression patterns; (2) elucidate the mechanisms underlying inappropriate "cryptic"...
The National Institute on Aging (NIA) awarded a $400,000 project grant (CFDA 93.866 - Aging Research) to The Trustees of the University of Pennsylvania, effective from September 15, 2024 to August 31, 2025. The grant supports the development of computational methods to measure epigenetic, transcriptomic, and splicing noise as indicators of cellular aging and senescence. The research aims to establish quantitative profiles of cellular aging and understand how gene dysregulation, senescence, and...
The National Institute on Aging (NIA) awarded a $1,334,474 Project Grant (CFDA 93.866 Aging Research) to the Regents of the University of Minnesota to develop single-cell and imaging methods using metal-bearing probes to monitor metabolic processes in live cells. The goal is to expand the use of mass cytometry (CyTOF and MIBI-TOF) in the biotechnological and biomedical fields. Key objectives include delivering molecular probes to viable cells, barcoding prenylation probes to explore molecular...
This National Institute on Aging (NIA) Project Grant award under CFDA 93.866 (Aging Research) will support research by the University of Minnesota to investigate the role of lipid metabolism, mitochondrial stress, and cellular senescence in age- and obesity-related metabolic dysfunction. The $153,512 grant, awarded on November 16, 2024, will fund a 10-month research project to characterize the biochemical and signaling mechanisms by which reactive lipid aldehydes can induce cellular...
This federal Project Grant award, with funding of $105,952 from the National Institute on Aging's Aging Research program (CFDA 93.866), supports the identification and characterization of clonal expansions in aging and aging-related diseases. The key objectives are to: Develop tools to accurately identify somatic variants at scale from publicly available data, and apply these tools to analyze the clonal architecture of conditions like diabetes, obesity, and hypertension in older individuals....
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to Brandeis University will support research investigating the role of retrotransposon activity in aging and age-related diseases using the Drosophila model system. The $331,187 award, effective from September 1, 2024 to August 31, 2028, aims to establish and characterize a Drosophila-based system to determine whether transposon activity is a cause or effect of the aging process. The research...
This federal Project Grant award, valued at $107,948.00, was provided by the National Institute on Aging under the Aging Research program (CFDA 93.866) to the Regents of the University of Minnesota. The primary objective of this research project is to investigate the role of regulatory T cells (Tregs) in Alzheimer's disease (AD) progression. Specifically, the research aims to characterize the types and spatial localization of Tregs in aging wild-type and AD mouse brains (Aim 1), and to determine...