The University of Pittsburgh was awarded a $2,358,537 Project Grant from the National Institute on Aging (CFDA 93.866 - Aging Research) to investigate the relationship between epigenetic aging, cognitive function, and the effects of exercise in older adults. The project, titled "Epigenetic Aging, Cognitive Function and Exercise in Older Adults," will leverage data and biospecimens from the existing IGNITE (Investigating Gains in Neurocognition in an Intervention Trial of Exercise) study involving 648 community-dwelling older adults aged 65-80 without cognitive impairment. Key objectives include elucidating the biologic underpinnings linking cognitive function, brain health, Alzheimer's disease biomarkers, and response to exercise interventions, with a focus on understanding how variation in biological aging processes contributes to these outcomes. The award period runs from September 1, 2024 through August 31, 2027.
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