This Project Grant award from the National Eye Institute (NEI) of the National Institutes of Health (CFDA 93.867 - Vision Research) provides $658,889 to the University of Rochester to investigate the role of the pro-inflammatory enzyme PLA2G2A/sPLA2-IIA in age-related macular degeneration (AMD). The research aims to utilize human donor eyes, patient-derived induced pluripotent stem cells, and transgenic mouse models to critically evaluate the mutation-independent pathogenic role of PLA2G2A in...
This Project Grant award from the National Eye Institute (CFDA 93.867 - Vision Research) provides $1,241,223 to the University of Pittsburgh to conduct research on the genetic and epigenetic circuits underlying retinal transcription programs and how perturbations in the retinal core regulatory networks lead to congenital vision disorders. The key objectives are to: 1) Use mouse models to dissect the molecular, cellular, and genomic effects of genetic mutations on retinal development; 2)...
This $429,016 federal Project Grant awarded by the National Eye Institute (CFDA 93.867 - Vision Research) to Oakland University supports research to identify the mechanisms by which a subset of retinal amacrine cells, called starburst amacrine cells, initiate and propagate spontaneous cholinergic waves in the developing retina. The objectives are to determine the distribution and properties of these cholinergic wave "pacemaker" cells (Aim 1) and to elucidate the calcium-dependent...
This Project Grant award, funded by the National Eye Institute (NEI) under the Vision Research federal grant program (CFDA 93.867), supports a research project focused on understanding genetic and glial support mechanisms in acute and chronic models of photoreceptor degeneration. The total award amount is $385,000.00 over a 4-year period from August 1, 2025 to July 31, 2029. The project, led by researchers at Wayne State University, aims to compare the transcriptional, cellular, and functional...
This $439,137 Project Grant was awarded by the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867) to the University of Arkansas for Medical Sciences (UAMS) to support research aimed at identifying cellular mechanisms and therapeutic targets for retinal neurovascular diseases such as diabetic retinopathy, retinal artery/vein occlusion, and traumatic optic neuropathy. The research will focus on studying the process of "efferocytosis", which refers to the...
The U.S. National Eye Institute (NEI) awarded a $184,117 Project Grant (CFDA 93.867 - Vision Research) to Oakland University to determine the role of G-coupled protein receptors GPR31 and GPR39 in the pathogenesis of diabetic retinopathy. The project aims to investigate the affinities and substrate specificities of GPR31 and GPR39 for 12- and 15-HETE metabolites in retinal endothelial cells and Müller cells under normal and hyperglycemic conditions. It will also examine the effects of GPR31 or...
The National Eye Institute (NEI) awarded a $624,230 Project Grant under the Vision Research program (CFDA 93.867) to the University of California, Los Angeles (UCLA) for the period of May 1, 2025 to April 30, 2029. The grant supports research to investigate the physiology of retinal degeneration and how the retina maintains visual processing as photoreceptors are lost. Key objectives include documenting changes in rod function and connectivity to bipolar cells, and exploring the plasticity and...
This $121,665 Project Grant, awarded by the National Eye Institute under the Vision Research program (CFDA 93.867), supports research at the University of Wisconsin-Madison to investigate signal processing mechanisms in the macaque retina. The project examines how regional variations in neural architecture, specifically differences in cell density and connectivity, impact the sensitivity and spatial encoding capabilities of two key retinal pathways - the rod pathway for dim light vision and...
This Project Grant awarded by the National Eye Institute (CFDA 93.867 Vision Research) provides $695,018 over a 5-year period starting August 1, 2025 to The Johns Hopkins University to conduct research on regulating retinal ganglion cell regeneration using Müller glia cells in zebrafish as a model. The key objectives are to: 1) Identify genes that regulate retinal ganglion cell regeneration and determine if they have universal or context-specific effects across other retinal cell types; 2)...
This Project Grant award from the National Eye Institute (CFDA 93.867 - Vision Research) provides $475,442 to the University of California, Los Angeles (UCLA) to conduct research focused on understanding the mechanisms underlying the ingestion of photoreceptor outer segment tips by the retinal pigment epithelium (RPE). The research aims to investigate the dynamic actin polymerization and trogocytosis process involved in this essential cellular function, as well as the daily timing of outer...