Project Grant R21EY037437
- The National Eye Institute (NEI) awarded a $437,310 Project Grant under the Vision Research federal grant program (CFDA 93.867) to the University of Rochester to conduct research on the molecular and physiological mechanisms of inner retinal remodeling in retinal degeneration. The research aims to elucidate the mechanisms behind genetic, morphological, and physiological changes in retinal ganglion cells that lead to decreased signal-to-noise ratio and corruption of retinal circuits, with the...
- The National Eye Institute (NEI) awarded a $190,538 Project Grant under the Vision Research federal grant program (CFDA 93.867) to the University of Nebraska Medical Center (UNMC) for a 2-year project titled "Using Optical Sensors to Measure Synaptic Glutamate Release from Retinal Rod Photoreceptor Cells". The project aims to develop and characterize the use of a genetically-modified fluorescent glutamate sensor to optically measure glutamate release at the synapses of rod...
- This federal Project Grant award of $146,922 from the National Eye Institute (NEI), under the Vision Research federal grant program (CFDA 93.867), supports research to investigate the role of ankyrins in mediating the development of synaptic connections between photoreceptors and their respective targets in the mammalian retina. The award to Baylor College of Medicine aims to elucidate the early molecular events that coordinate the selective wiring of photoreceptors, which is essential for...
- The National Eye Institute (NEI), under the federal Vision Research grant program (CFDA 93.867), awarded a $144,200 Project Grant to Pennsylvania State University's Milton S. Hershey Medical Center. The grant, effective June 1, 2025 through November 30, 2027, will fund research to characterize the molecular mechanisms underlying increased levels of the protein REDD1 in the retina due to diabetes, and explore alternative intervention strategies for preventing retinal complications caused by...
- The National Eye Institute (NEI), under the federal Vision Research grant program (CFDA 93.867), awarded a $595,302 project grant to Thomas Jefferson University, doing business as Sidney Kimmel Medical College, for the period of April 1, 2025 to March 31, 2030. The project aims to investigate how glucose and lactate support photoreceptor health and function in order to develop new treatment strategies to prevent vision loss. Specifically, the researchers will determine whether the retinal...
- This Project Grant award from the National Eye Institute (NEI), part of the U.S. Department of Health and Human Services, provides $385,000.00 in funding to Wayne State University to conduct research on genetic and glial support mechanisms in acute and chronic models of photoreceptor degeneration. The research aims to understand, prevent, and treat vision-related conditions and diseases, a focus area of NEI's Vision Research federal grant program (CFDA 93.867). The study will compare...
- The National Eye Institute (NEI) awarded a $451,000 Project Grant under the Vision Research federal grant program (CFDA 93.867) to the University of Chicago. The grant supports the "Development of the RGC Projectome" project, which aims to create comprehensive models describing how hundreds of thousands of retinal ganglion cell (RGC) axons faithfully grow in the proper direction during embryogenesis to establish proper vision. This research is critical, as disruptions in this process...
- This Project Grant award from the National Eye Institute's Vision Research program (CFDA 93.867) is supporting research at the Cleveland Clinic Lerner College of Medicine of Case Western Reserve University to investigate the role of neuronal activity on retinal angiogenesis and blood-retina barrier (BRB) maturation. The $248,999 award, effective from May 1, 2025 to April 30, 2028, aims to elucidate how neuronal synaptic activity, specifically cholinergic and glutamatergic neurotransmitters,...
- This federal Project Grant award of $624,230 was provided by the National Eye Institute (NEI) under the Vision Research federal grant program (CFDA 93.867) to the University of California, Los Angeles (UCLA) starting on May 1, 2025. The grant will support research to investigate changes in rod photoreceptor function and connectivity in the retina during the progression of retinal degeneration, with the goal of understanding how the retina maintains visual processing during cell loss. The...
- The National Eye Institute (NEI) awarded a $312,239 Project Grant under the Vision Research federal grant program (CFDA 93.867) to Shift Pharmaceuticals Holdings, Inc. for the development of an antisense oligonucleotide (ASO) therapeutic to inhibit retinoic acid signaling and mitigate vision loss in retinitis pigmentosa and age-related macular degeneration. The project aims to create a targeted ASO therapy that can block the production of retinoic acid receptors at the cellular level within...
The National Eye Institute (NEI), under the federal Vision Research grant program (CFDA 93.867), awarded a $431,750 Project Grant to the University of Louisville to study the role of neurexin proteins in retinal structure and function. The grant, effective from September 1, 2025 to August 31, 2027, aims to 1) determine the function of three neurexin genes and their isoform-specific expression patterns within the retina, and 2) characterize the cell-type-specific expression of neurexin isoforms using advanced single-cell sequencing techniques. The research seeks to provide the first comprehensive understanding of how neurexins, which are known to be important in neural disorders, contribute to maintaining the structure and function of the retina's first synapse. This project grant award is part of NEI's broader efforts to support vision research addressing leading causes of blindness and visual impairment.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $431.8k | 8/29/25 |