Project Grant K99MH141192
- Federal Grant Award Summary The National Institute of Mental Health (NIMH) awarded The Leland Stanford Junior University a $1,066,793 Project Grant under the Mental Health Research Grants program (CFDA 93.242) effective April 1, 2026, with a completion date of January 31, 2028. This research initiative, titled "Early TMS-EEG Potentials as Biomarkers for Personalized Neuromodulation in Treatment-Resistant Depression," develops and validates a personalized intermittent theta-burst...
- Federal Grant Award Summary The National Institute of Mental Health (NIMH) awarded The Leland Stanford Junior University a Project Grant totaling $160,272 under the Mental Health Research Grants program (CFDA 93.242) for the period of June 1, 2025, through May 31, 2027. This research project, titled "Theta Burst Modulation of Hippocampal-Cortical Rhythms in Schizophrenia," investigates whether connectivity-guided theta burst stimulation (TBS) can alter hippocampal neural activity and...
- Federal Grant Award Summary The National Institute of Mental Health (NIMH) awarded McLean Hospital a $777,016 Project Grant under the Mental Health Research Grants program (CFDA 93.242) effective July 1, 2025, through April 30, 2030. This research project investigates the synaptic mechanisms of continuous theta burst stimulation (cTBS), an FDA-cleared repetitive transcranial magnetic stimulation (rTMS) protocol used to treat treatment-resistant depression. The primary deliverables include...
- Federal Grant Award Summary The National Institute of Mental Health (NIMH) awarded The Leland Stanford Junior University a Project Grant totaling $192,192.00 (CFDA 93.242, Mental Health Research Grants) beginning April 15, 2026, and concluding March 31, 2031. This award supports the development of an artificial intelligence foundation model designed to advance the understanding and treatment of Major Depressive Disorder (MDD) through functional neuroimaging analysis. The project leverages...
- Federal Grant Award Summary The National Institute of Mental Health (NIMH) awarded the University of Pennsylvania a $762,440 Project Grant (CFDA 93.242 – Mental Health Research Grants) beginning April 1, 2026, and continuing through January 31, 2031, to develop and validate a standardized research protocol combining transcranial magnetic stimulation (TMS) with functional magnetic resonance imaging (fMRI). The primary deliverable is the creation of an interleaved TMS/fMRI protocol capable of...
- Federal Grant Award Summary The National Institute of Mental Health (NIMH) awarded the University of Wisconsin-Madison a $427,625 Project Grant under the Mental Health Research Grants program (CFDA 93.242) for the period April 1, 2026, through March 31, 2028. This award supports research aimed at enhancing sleep spindle activity through temporal interference transcranial electric stimulation (TI-TES) directed at the thalamus. The research addresses sleep spindle deficits as a promising biomarker...
- Federal Grant Award Summary The National Institute of Mental Health (NIMH) awarded The Leland Stanford Junior University a $744,121 Project Grant (CFDA 93.242: Mental Health Research Grants) effective July 14, 2025, through April 30, 2030, to develop Foundation Models (FMs) for human functional neuroimaging with applications to psychiatric disorders. The research initiative aims to create an integrated framework combining foundation models with explainable artificial intelligence (XAI)...
- Federal Grant Award Summary Ampa Inc. received a $1.2 million Project Grant from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) to develop and validate a next-generation Transcranial Magnetic Stimulation (TMS) system designed to democratize access to advanced depression treatment. The award, obligated on September 15, 2025, with a completion date of August 31, 2027, supports the company's development of the NextGenTM TMS system—a...
- Federal Grant Award Summary The National Institute of Mental Health (NIMH) awarded Washington University a Project Grant totaling $284,333 under the Mental Health Research Grants program (CFDA 93.242) on August 4, 2025, for research on mechanism-based dose titration strategies to modify brain electrophysiology during antidepressant therapy for treatment-resistant depression (TRD). The research will be conducted through June 30, 2029, and focuses on developing personalized medicine approaches...
- Federal Grant Award Summary The Laureate Institute for Brain Research, Inc. received a $514,178 Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242), effective July 1, 2025, through April 30, 2030. The award funds a five-year research initiative investigating the mechanistic relationships between brain circuits and negative valence system behaviors in treatment-resistant depression (TRD) using low-intensity...
The National Institute of Mental Health (NIMH) awarded Stanford University a $116,837 Project Grant (CFDA 93.242 - Mental Health Research Grants) effective May 4, 2026, through April 30, 2028, to advance transcranial magnetic stimulation (TMS) research for depression treatment. The project, titled "Sleep Theta Burst Stimulation for Improved Prefrontal Neuromodulation in Depression," develops and tests innovative neuromodulation techniques that deliver intermittent theta burst stimulation (ITBS) to the dorsolateral prefrontal cortex (DLPFC) during non-rapid eye movement sleep rather than during wakefulness. The research leverages the enhanced neural plasticity that occurs during sleep, particularly during slow-wave sleep and sleep spindles, to potentially improve TMS therapeutic efficacy for depression—a condition that currently achieves only moderate success with existing treatments. The project deliverables include basic neuroscience investigations utilizing intracranial electrical stimulation and intracranial electroencephalography (EEG) measurements in neurosurgical patients to quantify evoked responses and assess plasticity changes, as well as translational research testing TMS-delivered DLPFC stimulation during sleep. Research outputs will contribute to peer-reviewed publications and mechanistic insights into brain function relevant to mental health treatment, with the ultimate goal of establishing sleep-targeted TMS as a superior therapeutic approach for improving both brain function and behavioral outcomes in depression.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $116.8k | 5/7/26 |