Project Grant R44MH136880
- The National Institute of Mental Health (NIMH) awarded a $830,409 Project Grant under the Mental Health Research Grants program (CFDA 93.242) to Brigham & Women's Hospital Inc., a subsidiary of Partners Healthcare System, to develop novel software and computational techniques that integrate real-time navigated electric-field mapping and source-space electroencephalogram (EEG) analysis during transcranial magnetic stimulation (TMS) to improve the accuracy of targeting and dosimetry for...
- The National Institute of Mental Health (NIMH) awarded a $156,500 Project Grant under the Mental Health Research Grants program (CFDA 93.242) to Emory University to identify patients with true treatment failure for major depressive disorder (MDD) who may benefit from earlier referral to alternative treatments like transcranial magnetic stimulation, ketamine, and vagus nerve stimulation. The project aims to use trajectory classification methods to empirically separate partial response from true...
- This federal Project Grant award of $777,016.00 from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) supports a study on the synaptic mechanisms underlying repetitive transcranial magnetic stimulation (rTMS) protocols for the treatment of treatment-resistant depression. The study, titled "Synaptic Mechanisms of Continuous Theta Burst Stimulation in Depression," aims to investigate the neural mechanisms of the inhibitory...
- This federal Project Grant award, titled "MAINTENANCE RTMS FOR DEPRESSION (MAITR-DE)", is funded by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242). The $968,769 award will support a multi-site study to investigate the efficacy of maintenance repetitive transcranial magnetic stimulation (rTMS) in sustaining treatment response for individuals with treatment-resistant depression. The study will be conducted by the University of...
- This Project Grant award, provided by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242), supports research to establish reliable markers of prefrontal excitability that can be used to optimize repetitive transcranial magnetic stimulation (rTMS) treatment for depression. The $784,096 award, with a project period from May 1, 2025 to February 28, 2030, will allow researchers at The Leland Stanford Junior University to: 1) investigate how...
- This Project Grant award from the National Institute of Mental Health (NIMH), under CFDA 93.242 Mental Health Research Grants program, will provide $1,651,499.00 over 3 years to Magnetic Tides, Inc. to assess the proof-of-mechanism and efficacy of their novel Kilohertz Transcranial Magnetic Perturbation (KTMP) device for treating anhedonia in patients with major depressive disorder. The goal is to use KTMP to precisely modulate brain activity in the reward circuitry, specifically targeting the...
- The National Institute of Mental Health (NIMH) awarded a $514,178 Project Grant under the Mental Health Research Grants program (CFDA 93.242) to the Laureate Institute For Brain Research, LLC in Oklahoma City, Oklahoma. The grant will support research to better understand the mechanistic relationship between brain circuit function and abnormalities in negative valence system behaviors, such as anhedonia and rumination, that contribute to treatment-resistant depression. The project will employ...
- The National Institute of Mental Health (NIMH) awarded a $1,596,935 Project Grant under the Mental Health Research Grants program (CFDA 93.242) to Petcoil, Inc., a for-profit company based in Sunnyvale, California. The grant, awarded on March 11, 2025, with a planned completion date of February 29, 2028, supports the commercialization of a portable, brain-dedicated Positron Emission Tomography (PET) insert system that can be integrated with existing Magnetic Resonance Imaging (MRI) machines....
- The National Institute of Mental Health (NIMH) awarded a $505,311 Project Grant under the Mental Health Research Grants program (CFDA 93.242) to Intelligent Imaging Innovations, Inc. (3i), a for-profit manufacturer of advanced microscopy equipment and software based in Denver, Colorado. The two-year grant, awarded on January 1, 2025, seeks to establish the feasibility of combining recent advances in optical techniques to produce a commercial instrument that enables large-scale, all-optical...
- This Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), aims to develop personalized medicine strategies for tailored drug dose titration to modify brain electrophysiology during antidepressant therapy for treatment-resistant depression (TRD). The $284,333 award to The Washington University in Missouri will support research to enable dosing based on patient demographics and data-driven inferences of individual...
The National Institute of Mental Health (NIMH) awarded a $1,199,261 Project Grant under the Mental Health Research Grants program (CFDA 93.242) to Ampa Inc. The grant, awarded on September 15, 2025, will fund the development of a next-generation Transcranial Magnetic Stimulation (TMS) system that aims to make highly effective, personalized depression treatment more accessible and scalable. The key innovations include precision TMS targeting using neurocardiac response signals, camera-based neuronavigation, and optimized stimulation waveforms to minimize power requirements. This project seeks to eliminate the need for large equipment and highly specialized personnel, enabling SNT-type therapy to be delivered in a wider range of settings. The goal is to democratize access to state-of-the-art depression treatment and drive meaningful reductions in the nationwide prevalence of depression and suicidality.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $1.2m | 9/12/25 |