Project Grant R01MH139697

Award Date 7/1/25
Completion Date 4/30/30
Dollars Obligated $777K
Federal Grant Program
93.242
Assistance Type
Project Grant
Place of Performance
Belmont, MA 02478, USA
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This federal Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) aims to advance transcranial magnetic stimulation (TMS) technologies for the treatment of psychiatric disorders. The $382,480 award, granted on September 26, 2024, will support research to validate a closed-loop approach for prefrontal TMS using real-time electroencephalographic (EEG) recordings in a non-human primate model. The key objectives are...
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This federal Project Grant award, funded by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242), supports research to investigate the synaptic mechanisms underlying the use of continuous theta burst stimulation (CTBS), an inhibitory repetitive transcranial magnetic stimulation (rTMS) protocol, in the treatment of treatment-resistant depression.

The $777,016 grant, awarded to The Mclean Hospital Corporation in Belmont, MA, will test the role of N-methyl-D-aspartate receptor (NMDAR)-dependent long-term depression and gamma-aminobutyric acid receptor (GABAR)-mediated inhibition in the dorsolateral prefrontal cortex of 70 depressed subjects. The research will use a double-blind, randomized crossover study design to evaluate the underlying synaptic mechanisms of CTBS and how pharmacological modulation of these receptors impacts cortical excitability. The results are expected to guide the development of mechanism-informed, optimized TMS protocols for quieting overactive brain networks in depression and other mental health disorders.

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