Project Grant R01MH138375
- Federal Grant Award Summary The National Institute of Mental Health (NIMH) awarded McLean Hospital a $777,016 Project Grant under the Mental Health Research Grants program (CFDA 93.242) effective July 1, 2025, through April 30, 2030. This research project investigates the synaptic mechanisms of continuous theta burst stimulation (cTBS), an FDA-cleared repetitive transcranial magnetic stimulation (rTMS) protocol used to treat treatment-resistant depression. The primary deliverables include...
- Federal Grant Award Summary The National Institute of Mental Health (NIMH) awarded Stanford University a $1.46 million Project Grant under the Mental Health Research Grants program (CFDA 93.242) to develop optimized methods for measuring brain excitability in depression. Initiated on May 1, 2025, with completion targeted for February 28, 2030, this research addresses critical limitations in Repetitive Transcranial Magnetic Stimulation (rTMS) treatment for depression, which currently exhibits...
- Federal Grant Award Summary The National Institute of Mental Health (NIMH) awarded The Leland Stanford Junior University a Project Grant totaling $160,272 under the Mental Health Research Grants program (CFDA 93.242) for the period of June 1, 2025, through May 31, 2027. This research project, titled "Theta Burst Modulation of Hippocampal-Cortical Rhythms in Schizophrenia," investigates whether connectivity-guided theta burst stimulation (TBS) can alter hippocampal neural activity and...
- Federal Grant Award Summary Ampa Inc. received a $1.2 million Project Grant from the National Institute of Mental Health under the Mental Health Research Grants program (CFDA 93.242), awarded on September 15, 2025, with completion targeted for August 31, 2027. The project involves validation and development of NextGenTM, a next-generation Transcranial Magnetic Stimulation (TMS) system designed to democratize access to advanced depression treatment by eliminating the need for expensive, complex...
- Federal Grant Award Summary The National Institute of Mental Health (NIMH) awarded The Leland Stanford Junior University a $1,066,793 Project Grant (CFDA 93.242 – Mental Health Research Grants) effective April 1, 2026, through January 31, 2028, to develop and validate a personalized Intermittent Theta-Burst Stimulation (ITBS) protocol for treatment-resistant depression (TRD). The research delivers neurophysiological biomarker development and clinical validation services through a two-phase study...
- Federal Grant Award Summary The National Institute of Mental Health (NIMH) awarded the University of Pennsylvania a $221,302 Project Grant on March 1, 2026, under the Mental Health Research Grants program (CFDA 93.242). This two-year exploratory research project (R21 grant mechanism) aims to systematically assess the impact of mandatory National Institutes of Health (NIH) neuroethics requirements on the ethical design and conduct of brain-related human subjects research. The primary deliverables...
- Federal Grant Award Summary The National Institute of Mental Health (NIMH) awarded the University of Texas Health Science Center at Houston a $1,125,194 Project Grant under the Mental Health Research Grants program (CFDA 93.242) on August 15, 2025, to conduct a two-year clinical research study examining bilateral prefrontal and insular transcranial magnetic stimulation (TMS) for treating depression in schizophrenia spectrum disorders. The project addresses a critical clinical need, as depression...
- Federal Grant Award Summary The National Institute of Mental Health (NIMH) awarded University of Miami a $731,258 Project Grant, effective March 1, 2026, through November 30, 2030, under the Mental Health Research Grants program (CFDA 93.242). This research project aims to map neural dynamics associated with Major Depressive Disorder (MDD) and Generalized Anxiety Disorder (GAD) by utilizing high-stakes, real-world events as stimuli. The study will employ functional magnetic resonance imaging...
- Federal Grant Award Summary Magnetic Tides, Inc. received a $1.65M Project Grant from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) awarded on August 18, 2025, with a completion date of July 31, 2028. The award funds a three-year research initiative to develop and validate Kilohertz Transcranial Magnetic Perturbation (KTMP), a novel non-invasive brain stimulation technology designed to treat anhedonia in patients with Major...
- Federal Grant Award Summary Magnetic Tides, Inc. received a $557,588 Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242), effective August 15, 2025 through August 14, 2026. The award funds development of a two-coil Kilohertz Transcranial Magnetic Perturbation (KTMP) system that advances non-invasive brain stimulation (NIBS) technology. The primary deliverables include construction of a KTMP amplifier system capable...
The National Institute of Mental Health (NIMH) awarded the University of Pennsylvania a $762,440 Project Grant (CFDA 93.242 – Mental Health Research Grants) effective April 1, 2026, through January 31, 2031, to develop and validate a standardized protocol using interleaved transcranial magnetic stimulation (TMS) and functional magnetic resonance imaging (fMRI) for assessing the therapeutic mechanisms of neuromodulatory TMS treatments targeting anxiety disorders, posttraumatic stress disorder (PTSD), and depression. The primary deliverable is a proof-of-concept protocol measuring the effects of continuous theta burst stimulation (CTBS) applied to the right dorsolateral prefrontal cortex (DLPFC) on TMS-evoked bold (blood oxygen level-dependent) responses and anxiety measures in approximately 140 high-anxious subjects, comparing active stimulation against sham conditions to establish causal relationships between right DLPFC neuromodulation and downstream neural circuit activity. This research addresses a critical gap in understanding the mechanistic basis of TMS treatment efficacy by establishing a translational methodology that directly measures brain activity changes induced by therapeutic stimulation protocols. Expected research outputs include peer-reviewed publications, mechanistic insights into TMS-anxiety reduction pathways, and a validated assessment framework applicable to advancing novel TMS-based treatments for anxiety disorders and PTSD—outcomes aligned with NIMH's mission to transform understanding and treatment of mental illnesses through rigorous basic and clinical research.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $762.4k | 3/25/26 |