Project Grant R61MH140799
- Federal Grant Award Summary The National Institute of Mental Health (NIMH) awarded The Leland Stanford Junior University a Project Grant totaling $160,272 under the Mental Health Research Grants program (CFDA 93.242) for the period of June 1, 2025, through May 31, 2027. This research project, titled "Theta Burst Modulation of Hippocampal-Cortical Rhythms in Schizophrenia," investigates whether connectivity-guided theta burst stimulation (TBS) can alter hippocampal neural activity and...
- The National Institute of Mental Health (NIMH) awarded a $784,096 Project Grant to The Leland Stanford Junior University (Stanford University) through the Mental Health Research Grants program (CFDA 93.242). The goal of this 5-year grant, running from May 1, 2025 to Feb 28, 2030, is to investigate optimized methods for measuring brain excitability in depression using repetitive transcranial magnetic stimulation (rTMS). The research aims to establish reliable markers of prefrontal excitability...
- Federal Grant Award Summary The National Institute of Mental Health (NIMH) awarded The Leland Stanford Junior University a $1.45M Project Grant under the Mental Health Research Grants program (CFDA 93.242) on April 15, 2025, to develop an engineered bioprinting platform for studying neural migration in brain assembloids. The project, scheduled for completion by February 28, 2030, will deliver a novel magnetic three-dimensional bioprinting technology termed SPOT to enhance the quality,...
- Federal Grant Award Summary The National Institute of Mental Health (NIMH) awarded The Leland Stanford Junior University a $744,121 Project Grant (CFDA 93.242: Mental Health Research Grants) effective July 14, 2025, through April 30, 2030, to develop Foundation Models (FMs) for human functional neuroimaging with applications to psychiatric disorders. The research initiative aims to create an integrated framework combining foundation models with explainable artificial intelligence (XAI)...
- Federal Grant Award Summary Ampa Inc. received a $1.2M Project Grant from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242), awarded September 15, 2025, with completion targeted for August 31, 2027. The award funds development and validation of NextGenTM, a next-generation transcranial magnetic stimulation (TMS) system designed to democratize access to advanced depression treatment. The system incorporates three key innovations:...
- Federal Grant Award Summary The National Institute of Mental Health (NIMH) awarded McLean Hospital a $777,016 Project Grant under the Mental Health Research Grants program (CFDA 93.242) effective July 1, 2025, through April 30, 2030. This research project investigates the synaptic mechanisms of continuous theta burst stimulation (cTBS), an FDA-cleared repetitive transcranial magnetic stimulation (rTMS) protocol used to treat treatment-resistant depression. The primary deliverables include...
- Federal Grant Award Summary The National Institute of Mental Health (NIMH) awarded The Leland Stanford Junior University a $2.41 million Project Grant under the Mental Health Research Grants program (CFDA 93.242) effective August 8, 2025, through July 31, 2030. The award funds the Center for Responsible and Effective AI Technology Enhancement of Treatments for PTSD (CREATE), a multidisciplinary research center tasked with developing and evaluating large language model (LLM)-based artificial...
- Federal Grant Award Summary The Laureate Institute for Brain Research, Inc. received a $514,178 Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242), effective July 1, 2025, through April 30, 2030. The award funds a five-year research initiative investigating the mechanistic relationships between brain circuits and negative valence system behaviors in treatment-resistant depression (TRD) using low-intensity...
- Federal Grant Award Summary The National Institute of Mental Health (NIMH) awarded The Washington University a Project Grant of $284,333.00 under the Mental Health Research Grants program (CFDA 93.242), effective August 4, 2025, through June 30, 2029. The award supports research on mechanism-based dose titration for modifying brain electrophysiology during antidepressant therapy, with a specific focus on treatment-resistant depression (TRD). The project develops personalized medicine...
- Federal Grant Award Summary The National Institute of Mental Health (NIMH) awarded $818,253 to The Regents of the University of California, San Francisco under the Mental Health Research Grants program (CFDA 93.242) beginning July 1, 2025, and extending through April 30, 2030. This Project Grant supports a five-year research investigation examining neuromodulatory system abnormalities in late-life depression (LLD), with specific focus on the associations between structural and functional brain...
The National Institute of Mental Health (NIMH) awarded The Leland Stanford Junior University a Project Grant totaling $1,066,793 under the Mental Health Research Grants program (CFDA 93.242) effective April 1, 2026, with completion targeted for January 31, 2028. This research project develops and validates a personalized intermittent theta-burst stimulation (ITBS) protocol for treating treatment-resistant depression (TRD) by utilizing early transcranial magnetic stimulation–electroencephalography (TMS-EEG) potentials as biomarkers for neuromodulation optimization. The study addresses the critical gap that while repetitive transcranial magnetic stimulation (rTMS) benefits approximately half of TRD patients, stimulation parameters remain suboptimized for individual patients. The project employs a two-phase R61/R33 study design. The R61 phase will demonstrate target engagement through prefrontal excitability changes in 80 TRD patients, characterizing how ITBS parameters affect early local TMS-evoked potentials (EL-TEPs) during abbreviated protocols. The subsequent R33 phase will validate findings and establish clinical correlations in 106 new TRD patients by comparing EL-TEP-guided personalized ITBS protocols against standard approaches. By personalizing ITBS pulse count and intensity to maximize EL-TEP suppression, Stanford's research team seeks to enhance neural target engagement and improve clinical outcomes for individuals with treatment-resistant depression, ultimately advancing precision medicine approaches to neuromodulation therapy.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $1.1m | 3/11/26 |