Project Grant K99MH139907

Award Date 6/1/25
Completion Date 5/31/27
Dollars Obligated $160K
Federal Grant Program
93.242
Assistance Type
Project Grant
Place of Performance
California, USA
Similar Awards
The University of Pittsburgh is conducting a $420,685 project grant titled "Accelerated Neuromodulation of Prefrontal Circuitry During Clozapine Treatment" funded by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242). This two-year project seeks to explore the use of accelerated intermittent theta burst stimulation (iTBS) to enhance working memory and functional connectivity in individuals with treatment-resistant...
This $420,519 Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) will fund research to explore the use of temporal interference (TI) electrical neurostimulation as a non-invasive method for deep brain stimulation. The project aims to characterize the effects of TI on brain activity and functional connectivity using combined TI and fMRI in human subjects (Aim 1), and then apply TI to the dorsal anterior cingulate...
The National Institute of Mental Health (NIMH) awarded a $147,656 Project Grant (CFDA 93.242 - Mental Health Research Grants) to Beth Israel Deaconess Medical Center, Inc. in Boston, MA. The grant, with an award date of December 3, 2024 and ultimate completion date of June 9, 2026, will fund a study to develop a data-driven framework for mapping the effects of transcranial electrical stimulation on audiovisual integration and hallucinations. The research aims to determine if cathodal...
This $246,000 Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) aims to investigate the role of the dentate gyrus, a part of the hippocampus, in the pathophysiology of psychosis. The primary objective is to reverse-translate discoveries from post-mortem human brain analyses to modulate dentate gyrus excitatory neuron activity in an age-dependent manner using chemogenetic techniques. The project will...
The National Institute of Mental Health (NIMH) awarded a Project Grant (CFDA 93.242 - Mental Health Research Grants) in the amount of $565,921 to the University of Texas Health Science Center at Houston. The grant, titled "Alternative Stimulation Mode and Location for Auditory Hallucination Neuromodulation Treatment," aims to use a novel approach to design repetitive transcranial magnetic stimulation (rTMS) treatment for auditory hallucinations in patients with schizophrenia spectrum...
The General Hospital Corporation, doing business as Massachusetts General Hospital (MGH), was awarded a $459,250 federal Project Grant from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242). The 2-year grant, running from August 15, 2023 to August 14, 2025, will fund research to investigate the state-dependent effects of transcranial alternating current stimulation (TACS) on theta-gamma cross-frequency coupling and fronto-parietal...
The National Institute of Mental Health (NIMH) awarded a $498,429 Project Grant (CFDA 93.242 - Mental Health Research Grants) to the Children's Research Institute in Washington, D.C. The project, titled "Identifying the Multi-Modal Factors that Determine Individual Response to tDCS," aims to apply advanced machine learning algorithms to a unique multimodal dataset of over 225 transcranial direct current stimulation (tDCS) sessions. The goal is to determine which factors, such as...
This federal Project Grant award for $2,516,931.00, provided by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242), will support a multidisciplinary research project to investigate the neural circuit mechanisms underlying auditory hallucinations (AH) in schizophrenia. The project aims to use a novel computational circuit-level model combined with translational experiments in humans and mice to elucidate the role of dopaminergic...
This $735,932 federal Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), aims to elucidate the cellular and neuronal mechanisms underlying positive symptoms of schizophrenia. The grantee, St. Jude Children's Research Hospital, will conduct research to characterize disruptions in thalamocortical projections and abnormal neuronal activity in the auditory cortex of mouse models harboring genetic risk factors for...
This Project Grant award from the National Institute of Mental Health (NIMH) under CFDA 93.242 - Mental Health Research Grants, provides $231,547 to George Mason University to conduct research on the regulation of hippocampal network dynamics and spatial memory deficits associated with schizophrenia. The research aims to examine how specific signaling pathways downstream of NMDA receptor activation, particularly those involving the GluN2B subunit, impact theta and slow gamma oscillations,...

This $160,272 Project Grant awarded by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) supports a research project titled "Theta Burst Modulation of Hippocampal-Cortical Rhythms in Schizophrenia." The overarching goal is to investigate whether connectivity-guided theta burst stimulation (TBS) can alter hippocampal neural activity and cognitive function in patients with schizophrenia. The project will involve a combination of invasive brain stimulation experiments using intracranial recordings as well as non-invasive TBS delivered via transcranial magnetic stimulation and scalp electroencephalography in schizophrenia patients. The research aims to advance the understanding of how the hippocampus responds to theta burst stimulation and explore the potential of using this form of neuromodulation to improve hippocampal physiology and cognitive function in schizophrenia. The 2-year project will be conducted at Stanford University, which has significant expertise in human intracranial electrophysiology, hippocampal memory function, and brain stimulation research.

Generated 6/17/25, 3:19 AM