Project Grant R21MH141540
- Federal Grant Award Summary The National Institute of Mental Health (NIMH) awarded The Leland Stanford Junior University a Project Grant totaling $160,272 under the Mental Health Research Grants program (CFDA 93.242) for the period of June 1, 2025, through May 31, 2027. This research project, titled "Theta Burst Modulation of Hippocampal-Cortical Rhythms in Schizophrenia," investigates whether connectivity-guided theta burst stimulation (TBS) can alter hippocampal neural activity and...
- Federal Grant Award Summary The National Institute of Mental Health (NIMH) awarded The Washington University a Project Grant of $284,333.00 under the Mental Health Research Grants program (CFDA 93.242), effective August 4, 2025, through June 30, 2029. The award supports research on mechanism-based dose titration for modifying brain electrophysiology during antidepressant therapy, with a specific focus on treatment-resistant depression (TRD). The project develops personalized medicine...
- Federal Project Grant Award Summary The University of Wisconsin-Madison received a $1.56 million Project Grant from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) to conduct a four-year research study (August 1, 2025 – July 31, 2029) optimizing the integration of human and digital support components within the Healthy Minds Program (HMP), a widely-used meditation application for treating depression and anxiety. The research...
- Federal Grant Award Summary Indiana University received a $420,519 Project Grant from the National Institute of Mental Health under the Mental Health Research Grants program (CFDA 93.242) effective May 15, 2025 through May 14, 2027. The award funds research into Temporal Interference (TI) electrical neurostimulation as a non-invasive deep brain stimulation technology. The project will deliver two primary research products: (1) characterization of TI's effects on blood oxygen level-dependent...
- Federal Grant Award Summary The National Institute of Mental Health (NIMH) awarded McLean Hospital a $777,016 Project Grant under the Mental Health Research Grants program (CFDA 93.242) effective July 1, 2025, through April 30, 2030. This research project investigates the synaptic mechanisms of continuous theta burst stimulation (cTBS), an FDA-cleared repetitive transcranial magnetic stimulation (rTMS) protocol used to treat treatment-resistant depression. The primary deliverables include...
- This federal Project Grant award of $498,429, provided by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242), supports research to identify the key factors that determine an individual's response to transcranial direct current stimulation (tDCS). The research aims to apply machine learning algorithms to a large, multimodal dataset of over 225 tDCS-fMRI sessions to determine which factors, such as baseline task performance, brain...
- Federal Project Grant Award Summary The National Institute of Mental Health (NIMH) awarded the Research Institute at Nationwide Children's Hospital a $392,500 project grant under the Mental Health Research Grants program (CFDA 93.242) to conduct research characterizing the role of sleep brain dynamics in the emergence of depression in adolescents. The project, spanning from May 1, 2025, to April 30, 2027, will investigate biological markers of depression onset in high-risk adolescent...
- Federal Grant Award Summary The University of Chicago received a $410,000 Project Grant from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242), awarded on July 1, 2025, with completion targeted for June 30, 2027. This exploratory research project delivers investigative services and methodological development aimed at understanding how noninvasive brain stimulation affects hippocampal-dependent memory function. The research utilizes...
- Federal Project Grant Award Summary The National Institute of Mental Health (NIMH) awarded The Leland Stanford Junior University a Project Grant totaling $1,066,793 under the Mental Health Research Grants program (CFDA 93.242) effective April 1, 2026, with completion targeted for January 31, 2028. This research project develops and validates a personalized intermittent theta-burst stimulation (ITBS) protocol for treating treatment-resistant depression (TRD) by utilizing early transcranial...
- Federal Grant Award Summary The Medical College of Wisconsin, Inc. received a $521,266 Project Grant from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242), awarded on March 15, 2026, with a completion date of January 31, 2031. This award supports basic neuroscience research investigating the role of mechanistic target of rapamycin (mTOR) signaling in midbrain dopamine neurons and its relationship to hyperactivity and impulsivity...
The University of Wisconsin-Madison received a $427,625 Project Grant from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) for the period April 1, 2026 through March 31, 2028. The grant funds research to develop and optimize Temporal Interference Transcranial Electric Stimulation (TI-TES) as a neuromodulatory technique for targeting thalamic circuits in healthy subjects during non-rapid eye movement sleep. The research aims to identify optimal TI-TES parameters for enhancing sleep spindle activity—a biomarker implicated in schizophrenia spectrum disorder—and to determine differential effects on fast and slow spindle subtypes and related neural coupling patterns. The project delivers empirical data through a controlled experimental design utilizing personalized, multipolar TI-TES combined with high-density electroencephalography during N2 sleep stages in study participants. The research objectives include: (1) identifying optimal TI-TES frequency and location parameters for enhancing spindle frequency activity, and (2) characterizing selective effects on distinct spindle subtypes, slow waves, and slow oscillation-spindle coupling. This foundational research in healthy subjects is designed to generate the evidence base necessary for future clinical translation toward restoring normal spindle activity in schizophrenia spectrum disorder patients through personalized thalamic stimulation approaches.Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $427.6k | 3/9/26 |