Project Grant K08DK146197
- Federal Grant Award Summary The Children's Hospital of Philadelphia Research Institute received a $836,942 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), effective September 15, 2025, through July 31, 2030. This award supports research investigating the molecular mechanisms of autophagy in intestinal regeneration and injury response. The research...
- Federal Grant Award Summary The Children's Hospital of Philadelphia Research Institute received a $171,639 Project Grant award dated July 16, 2025, from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). This career development award supports a multi-omic investigation into uremic toxin sources and accumulation in pediatric patients with kidney failure, encompassing both...
- Federal Grant Award Summary Boston Children's Hospital received a $469,042 Project Grant from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), effective September 1, 2025 through August 31, 2027. The award supports the development and optimization of a human induced pluripotent stem cell (iPSC)-derived bone marrow organoid platform designed to advance hematopoiesis...
- Federal Project Grant Award Summary Boston Children's Hospital received a $154,860 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), effective August 1, 2025, with completion targeted for May 31, 2028. This award supports fundamental research investigating the mechanisms of clonal competition in age-related clonal hematopoiesis (CH), a condition in...
- Federal Grant Award Summary The University of California, San Francisco received a $2.78 million Project Grant from the National Institute of Diabetes and Digestive and Kidney Diseases under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), awarded on September 15, 2025, with completion anticipated by September 14, 2029. This research initiative develops human pluripotent stem cell (HPSC)-derived models of the enteric nervous system to advance...
- Federal Grant Award Summary The Children's Hospital of Philadelphia Research Institute received a $812,200 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), effective August 1, 2025 through July 31, 2030. The award supports research investigating the role of enterococci bacteria in reshaping Clostridioides difficile infection (CDI) pathogenesis and virulence expression in the...
- Federal Project Grant Award Summary Cincinnati Children's Hospital Medical Center received a $2,086,360 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), effective September 11, 2025, through September 10, 2029. The award supports a multidisciplinary research initiative investigating the role of nucleotide-binding oligomerization domain-containing 2...
- Summary of Federal Project Grant Award The Children's Hospital of Philadelphia (CHOP) Research Institute received a $451,034 Project Grant award effective September 15, 2025, through August 31, 2027, under the Trans-NIH Research Support program (CFDA 93.310) funded by the National Institutes of Health (NIH) Office of the Director. The award supports the CASCADE (Cardiometabolic Risk and Comorbidities in Adults with Down Syndrome—Electronic Health Record Examination) study, which aims to...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded The Children's Hospital of Philadelphia (CHOP) a $881,303 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) on July 17, 2025, with a completion date of June 30, 2030. This award funds a comprehensive investigation into hospital-acquired infection transmission in Neonatal Intensive Care Units (NICUs) using whole genome sequencing (WGS) and diagnostic allele...
- Federal Grant Award Summary This five-year Mentored Clinical Scientist Research Career Development Award was granted on September 15, 2025, by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to The Children's Hospital of Philadelphia Research Institute. The award obligates $159,408.00 in funding through July 31, 2030, to support research investigating the role of hepatic...
The Children's Hospital of Philadelphia (CHOP) Research Institute received a $159,288 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), effective February 1, 2026, through January 31, 2031. This research initiative investigates the pathogenic mechanisms of Hirschsprung Disease Associated Enterocolitis (HAEC), the leading cause of death in children with Hirschsprung disease. The project focuses on elucidating the role of interleukin-22 (IL-22) in HAEC development and severity, with the central hypothesis that enteric nervous system signaling induces IL-22 release to enhance mucosal immunity and strengthen epithelial barrier functions that prevent enterocolitis. The funded research employs the Piebald Lethal mouse model of Hirschsprung disease and human organoid systems derived from affected patients to characterize IL-22 cellular sources and define IL-22's specific role in epithelial integrity, stem cell renewal, and differentiation. Research outcomes will deliver foundational knowledge regarding immune-targeted therapeutic mechanisms for HAEC treatment and prevention, addressing a critical gap in clinical interventions for this pediatric gastrointestinal disease.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $159.3k | 1/14/26 |