Project Grant R21DK142111
- This Project Grant award, valued at $801,000.00, was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The funding supports research at The Children's Hospital Corporation, doing business as Boston Children's Hospital, to investigate the role of stress granules in red blood cell development, particularly during stress conditions. The research aims to uncover the...
- This federal Project Grant award of $154,860 from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847) supports research on the mechanisms of clonal competition in age-related clonal hematopoiesis. The grant, awarded to The Children's Hospital Corporation (Boston Children's Hospital), aims to investigate factors that drive the expansion of "super-competitor" clones bearing DNMT3A mutations, which are associated with increased risk of hematologic diseases...
- This $681,562 Project Grant awarded by the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) aims to investigate approaches for enhancing the metabolic maturity and functionality of human pluripotent stem cell-derived islet organoids, with the goal of improving their survival and efficacy for transplantation as a treatment for type 1 diabetes. The research will examine the use of pharmacological agents...
- This federal Project Grant award of $133,328 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research at The General Hospital Corporation, doing business as Massachusetts General Hospital (MGH), to dissect the roles of the PPM1D and TP53 genes in hematopoietic stem cells and clonal hematopoiesis. The research aims to understand how mutations in these genes...
- This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $143,968.00 to support research on early detection and treatment of hematopoietic stem cell transplant-associated thrombotic microangiopathy (HSCT-TMA). The research aims to examine whether markers of endothelial injury and complement overactivation can predict HSCT-TMA, as well...
- This $200,000 federal Project Grant award was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant supports research at Baylor College of Medicine in Houston, Texas to investigate how proteostatic (protein homeostasis) stress influences the fate and function of hematopoietic stem cells (HSCs). The research aims to systematically map how specific proteostatic...
- This $2,024,340 Project Grant was awarded on August 15, 2025 by the National Heart Lung and Blood Institute (NHLBI), part of the National Institutes of Health, under the Cardiovascular Diseases Research federal grant program (CFDA 93.837). The grant supports a multi-year research effort at Boston Children's Hospital to optimize outcomes for hematopoietic stem cell transplantation (HCT), an essential treatment for high-risk non-malignant and malignant hematologic diseases. The research project...
- This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) provides $1,123,357.00 to support research on the bone marrow microenvironment and its role in regulating blood cell production. The research, to be conducted by the Children's Hospital Medical Center in Cincinnati, Ohio, aims to define the spatial organization and specialized vascular microenvironments within the bone marrow that recruit and...
- This federal Project Grant award, with a total funding amount of $645,617, was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant is aimed at understanding the dysfunction of hematopoietic stem cells in refractory Crohn's disease, a condition that is resistant to traditional treatments. The research will profile hematopoietic stem cell populations...
- This federal Project Grant award for $836,942 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) supports research into the role of autophagy (self-digestion) in intestinal regeneration and stem cell activity. The research aims to investigate how autophagy contributes to injury resistance and the ability of certain intestinal cell types to re-acquire stem cell-like...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), is for the transformation of a human-induced pluripotent stem cell (iPSC)-derived bone marrow organoid to study hematopoiesis. The key objectives are to perform cellular mapping of the organoid, optimize it for the study of hematopoietic development, and culture the organoid under specific conditions. The total funding amount is $469,042, with the award period running from Sep 1, 2025 to Aug 31, 2027. The work will be conducted by The Children's Hospital Corporation, doing business as Boston Children's Hospital, a premier pediatric medical research institution in Massachusetts.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $469.0k | 8/29/25 |