Project Grant K08DK141964
- This $1,558,188 federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), will fund research to investigate how changes in transcription factor and heterochromatin states in embryos and adult livers impact hepatocyte development, homeostasis, and regeneration. The project, led by researchers at the University of Pennsylvania, will utilize advanced...
- This federal Project Grant award of $122,454, provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research investigating the role of the GIMAP5 gene in maintaining liver homeostasis. The primary recipient, Yale University, is conducting studies to determine how loss of function in the GIMAP5 gene leads to capillarization and dedifferentiation of liver...
- This Project Grant award of $806,192 was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant supports research to delineate how a deficiency in the ATP-binding cassette protein MRP9 causes injury to cholangiocytes, the cells that line the bile ducts, in chronic cholestatic liver diseases. The research is being conducted by the Children's Hospital Medical...
- This $166,752 federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research program) supports a 5-year career development training program at Boston University Medical Campus focused on studying the basic mechanistic underpinnings of alpha-1 antitrypsin deficiency (AATD) associated liver disease. The goal is to develop new treatments for these patients while simultaneously...
- This federal Project Grant award for $664,769.00, provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), is supporting research conducted by Oregon Health & Science University to develop allogeneic hepatocyte (liver cell) transplantation without the need for immunosuppression. The research aims to overcome key barriers to wider adoption of liver cell therapy,...
- This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $658,426 to The Children's Hospital of Philadelphia (CHOP) to conduct research on chronic STAT3 signaling and its impact on CD8 T cell dysfunction. The key objectives are to investigate the role of the CD39/adenosine axis in impairing CD8 T cell function in the context of STAT3 gain-of-function (GOF) disease, and to...
- This $3,176,680 federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) supports research at the University of California, San Francisco (UCSF) to investigate the role of the scavenger receptor MARCO in regulating the balance between regulatory and immunogenic immune responses in the neonatal liver. The research aims to elucidate how MARCO expressed on liver macrophages...
- The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $3,233,421 Project Grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to Yale University. The grant, with a performance period of September 1, 2025 to August 31, 2029, will support research to investigate the role of neutrophils in the pathogenesis of cholangiopathies - chronic liver diseases affecting bile ducts. The research aims to elucidate the...
- This federal Project Grant award for $836,942 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) supports research into the role of autophagy (self-digestion) in intestinal regeneration and stem cell activity. The research aims to investigate how autophagy contributes to injury resistance and the ability of certain intestinal cell types to re-acquire stem cell-like...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $441,375 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to Children's Hospital Medical Center (UEI JZD1HLM2ZU83) to conduct research on the "Transcriptional Mechanisms of Chronic Inflammation in Genetically Diverse Tissue Macrophages." The project will focus on understanding the genetic factors and regulatory mechanisms that contribute to the development of metabolic...
This federal Project Grant award of $159,408, provided by the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research), supports research at The Children's Hospital of Philadelphia (CHOP) to elucidate the role of effector CD8 T-cell and Kupffer cell interferon-gamma interaction in pediatric activated T-cell acute liver failure. The 5-year project aims to help the principal investigator become an independent academic investigator in the field of liver immunology. The research focuses on understanding the dysregulated immune responses that result in pediatric acute liver failure, with a specific emphasis on the hepatic interferon-gamma response in pediatric activated T-cell hepatitis/ALF.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $159.4k | 9/11/25 |