Project Grant K23DK144665

Award Date 7/16/25
Completion Date 3/31/30
Dollars Obligated $172K
Federal Grant Program
93.847
Assistance Type
Project Grant
Place of Performance
Pensilvania, EE. UU.
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  1. Characterize novel and known contributions of gut microbes to the biosynthetic pathways of selected uremic toxins using a multi-meta-omics approach.
  2. Identify differences in toxin accumulation and clearance between children requiring continuous veno-venous hemodiafiltration vs. those with chronic kidney disease stage 5 requiring chronic dialysis.

This 5-year project leverages existing CHOP infrastructure and sample biobanks to support the research and career development of the early-stage investigator leading the effort. The award aims to advance the candidate's capabilities in multi-omics, biostatistics, and clinical trial design to become an independent translational researcher focused on improving monitoring and interventions for modifiable toxins in pediatric kidney failure.

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