Project Grant R01DK142437
- This Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), provides $339,000.00 to New York University (NYU) School of Medicine to conduct research on the genetic factors underlying Hirschsprung disease, a rare developmental disorder. The research aims to comprehensively characterize the genetic basis of Hirschsprung disease by analyzing whole genome sequencing data...
- This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $722,908 to The Children's Hospital of Philadelphia to conduct research aimed at finding new ways to prevent and treat Hirschsprung disease-associated enterocolitis (HAEC), a life-threatening bowel inflammation. The key goals are to analyze stool metabolites, stool microbes, and gut...
- This $2,618,975 Project Grant was awarded on September 8, 2025 by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), part of the National Institutes of Health, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The funding supports a 5-year research project led by the University of Texas Health Science Center at Houston to advance the development and functional capabilities of tissue-engineered intestine as a potential cure...
- This federal Project Grant award of $176,244 from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847) to the University of California, San Francisco supports a 5-year research and training plan focused on the mechanisms underlying ciliary kidney diseases. The grant recipient, Dr. Gabriel Loeb, will investigate whether the transcription factor GLIS3 is regulated by the polycystin proteins and acts downstream of them to prevent kidney cyst formation. This work aims...
- This federal Project Grant award, with a total funding amount of $645,617, was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant is aimed at understanding the dysfunction of hematopoietic stem cells in refractory Crohn's disease, a condition that is resistant to traditional treatments. The research will profile hematopoietic stem cell populations...
- The National Institute of Child Health and Human Development (NICHD) awarded a $441,375 Project Grant under the Child Health and Human Development Extramural Research program (CFDA 93.865) to Children's Hospital Medical Center in Cincinnati, Ohio. The project aims to develop "Microglia-Integrated Brain Organoids for Gaucher Disease Modeling and Therapeutic Discovery". The grant will support the creation of brain organoid models that incorporate microglia to study the mechanisms of...
- This federal Project Grant award of $630,847 was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The award supports research conducted by Children's Mercy Hospital in Kansas City, Missouri to study the role of the SIGIRR gene in regulating intestinal barrier function and preventing necrotizing enterocolitis (NEC) in preterm infants. The key focus areas include...
- This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), totals $129,619 and will fund research on the interactions between the gut microbiome, intestinal development, and metabolic health in the context of fetal growth restriction (FGR). The overarching goal is to investigate how impaired intestinal and gut microbial development in FGR increases the...
- This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $164,700 to the University of California, Davis to investigate the mechanosensitive regulation of intestinal smooth muscle cell calcium signaling during gut development. The overarching goal is to improve understanding of the underlying mechanisms contributing to prematurity-related...
- This $2,970,076 federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) aims to investigate the developmental programming of adult intestinal stem cells (ISCs) and how an obesogenic maternal environment during pre- and postnatal development can establish a maladaptive pre-pathological ground state in offspring. Using genetically engineered mouse and organoid models, the...
This federal Project Grant award of $2,781,801 from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research) supports research to better understand Hirschsprung disease, a severe congenital gastrointestinal disorder. The grant, awarded to the University of California, San Francisco, aims to systematically explore the impacts of known Hirschsprung disease mutations on the development of the enteric nervous system using human pluripotent stem cell-derived models. The research will employ single-cell transcriptomics, functional assays, and transplantation experiments in mouse models to unravel mutation-specific effects on enteric nervous system function and identify potential therapeutic targets. The anticipated outcomes are expected to drive the inception of broad-spectrum therapeutic strategies and personalized treatment approaches to improve quality of life for individuals affected by Hirschsprung disease.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $2.8m | 9/9/25 |