Project Grant R01AI187174
- The Children's Hospital of Philadelphia (CHOP) was awarded a $881,303 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The grant aims to use whole genome sequencing and diagnostic allele surveillance to determine the transmission and persistence dynamics of bacterial infections in neonatal intensive care units (NICUs). The project will assess the impact of patient, pathogen, and...
- The National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855), awarded a $136,104 Project Grant to Tufts University School of Medicine. The grant, awarded on October 24, 2025, will support research to investigate the effect of Clostridioides difficile's (C. difficile) spatial distribution and toxin gene expression within the colon on disease severity. The research will utilize fluorescent reporter strains...
- This $233,250 Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) aims to optimize culture and metagenomic methods to detect multi-strain Clostridioides difficile (C. difficile) colonization and infection. The 2-year project seeks to enhance the recovery of multiple and cryptic C. difficile strains from stool samples by employing a combination of culture conditions. Additionally, the project will...
- This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $521,030.00 to the University of North Carolina at Chapel Hill to conduct research on the role of phenotypic heterogeneity in the fitness of Clostridioides difficile, a leading cause of antibiotic-associated disease. The goal is to define the interplay between stochastic and regulatory mechanisms underlying the...
- This $241,500 Project Grant, awarded by the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) and dated Aug 21, 2025, supports research conducted by the University of California, Davis to accelerate microbiota recovery and restore colonization resistance against Clostridioides difficile infection. The project aims to: (1) determine whether treatment with the probiotic Anaerostipes caccae can accelerate microbiota recovery after...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $161,859 Project Grant under the Allergy and Infectious Diseases Research (CFDA 93.855) program to Texas A&M University System Health Science Center (TAMU HSC) to conduct research on discovering novel antivirulence drug targets for Clostridioides difficile infection (CDI). The research aims to identify genetic mechanisms that regulate the production of virulence toxins by C. difficile, with the goal of finding...
- This $780,162 Project Grant from the National Institutes of Health's National Institute of Allergy and Infectious Diseases will fund research at Old Dominion University from August 2022 through July 2026 exploring the role of nutrient and stress sensing in regulating Clostridioides difficile physiology and behavior within the host. The research aims to determine how the stringent response regulates disease-relevant bacterial processes and characterize enzymes that mediate alarmone metabolism...
- This Project Grant award, valued at $184,651, was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855). The award will support research at Duke University focused on improving the understanding of the progression from Clostridioides difficile (C. difficile) carriage to active infection. Specifically, the research aims to: 1) Identify metagenomic and metabolomic risk factors present...
- This $894,552 project grant from the National Institutes of Health's National Institute of Allergy and Infectious Diseases Allergy and Infectious Diseases Research program (CFDA 93.855) will fund research at the University of Nevada, Las Vegas to probe the effect of a high-fat/high-protein diet on Clostridioides difficile infection. Specifically, the researchers will examine how such a diet impacts inflammation, intestinal permeability, and the gut microbiome before and after antibiotic...
- This Project Grant award of $2,872,722 from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to elucidate the role of penicillin-binding proteins (PBPs) in the Clostridioides difficile life cycle and develop new PBP inhibitors to target C. difficile sporulation. The research aims to enhance the understanding of PBPs across bacterial species and provide new insights into the unique...
The Children's Hospital of Philadelphia (CHOP) was awarded a $812,200 Project Grant from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) to conduct research on the role of enterococci in reshaping Clostridioides difficile infection (CDI). The 5-year project aims to provide a molecular blueprint of CDI and mechanistic insights into how the gut microbiota impacts C. difficile virulence. Leveraging advanced imaging mass spectrometry, the research will investigate how opportunistic pathogens like enterococci remodel the gut metabolic environment, which can influence C. difficile energy production and disease severity. This work seeks to deepen the understanding of polymicrobial interactions during enteric infections, which is crucial for improving prevention and treatment strategies for CDI, a significant global health challenge.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $812.2k | 7/25/25 |