Project Grant R01DK141702
- This federal Project Grant award of $1,222,594.00, provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research investigating the role of glutathione peroxidase 3 (GPX3) in regulating esophageal epithelial remodeling, subepithelial fibrosis, and eosinophil recruitment in eosinophilic esophagitis (EoE). The research, led by the primary awardee Vanderbilt...
- This $153,799 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research to characterize the molecular pathways responsible for the initiation and persistence of eosinophilic esophagitis (EoE), a highly inflammatory condition of the esophagus. The University of Utah will conduct RNA sequencing of esophageal tissues during food elimination and reintroduction diets to...
- The National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research federal grant program (CFDA 93.855), awarded a $3,375,359 Project Grant to The Children's Hospital of Philadelphia (CHOP) to conduct research on the impact of cytokine signaling on epithelial reprogramming and barrier dysfunction in eosinophilic esophagitis (EOE). The project aims to examine the specific roles of STAT3 and STAT1 in regulating STAT6-driven epithelial barrier...
- This Project Grant award of $226,980 was provided by the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research (CFDA 93.855) federal grant program. The funding will support research at Thomas Jefferson University to investigate the role of the GPR15-C10ORF99 pathway in T cell homing during eosinophilic esophagitis (EoE). EoE is a chronic inflammatory disease characterized by eosinophilic infiltration of the esophagus, which can lead...
- This federal Project Grant award of $183,600.00 was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant will support a 5-year research and career development plan for the principal investigator, Dr. Amiko Uchida, to investigate how dietary changes impact the gut microbiome composition and function in patients with eosinophilic esophagitis (EoE), a chronic...
- This $784,280 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research program) will support research to investigate the role of post-transcriptional modifications in regulating esophageal basal cell function and regeneration. The primary recipient, The Trustees of Columbia University in the City of New York, will use a combination of mouse genetics, sequencing, and CRISPR/Cas9...
- This Project Grant award of $234,000 was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant supports research at the University of Colorado-Denver to investigate the role of the Aiolos transcriptional regulator in the pathogenesis of inflammatory bowel disease. The researchers aim to utilize CRISPR-Cas9 genome editing to examine how Aiolos regulates T cell...
- This Project Grant award, funded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), aims to investigate the role of the MRGPRX4 receptor in mediating bile acid-induced activation and sensitization of esophageal nociceptive C-fibers. The $565,338 award will support a 5-year research project at The Johns Hopkins University to characterize the expression of MRGPRX4 in...
- This federal Project Grant award of $458,047.00 was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant aims to understand how extracellular vesicles (EVs) from intestinal epithelial cells (enterocytes) mediate cell-to-cell communication and function as effectors of inflammation in inflammatory bowel disease (IBD). Specific objectives include identifying...
- This federal Project Grant award of $630,847 was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The award supports research conducted by Children's Mercy Hospital in Kansas City, Missouri to study the role of the SIGIRR gene in regulating intestinal barrier function and preventing necrotizing enterocolitis (NEC) in preterm infants. The key focus areas include...
This federal Project Grant award, funded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), aims to investigate the role of rare genetic variants in the NOD2 gene in the pathogenesis of eosinophilic esophagitis (EOE). The $2,086,360 award to Children's Hospital Medical Center in Cincinnati, OH will fund a 4-year research project to examine how NOD2 variants impair epithelial barrier integrity and drive inflammatory responses in the esophagus, using human induced pluripotent stem cell-derived esophageal organoids. The project will explore the mechanistic pathways, including NF-kB signaling and reactive oxygen species production, that contribute to epithelial dysfunction in EOE. This research extends previous genome-wide association studies that have implicated genetic factors in the development of this chronic allergic inflammatory disorder.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $2.1m | 9/10/25 |