Project Grant K01AG094891
- The National Institute on Aging awarded the Regents of the University of Michigan $284,108 on January 1, 2026, under the Aging Research program (CFDA 93.866) to investigate how mechanical changes in the aging brain affect microglial function and Alzheimer's disease progression. The project explores the relationship between age-related mechanical alterations in brain tissue—specifically decreased stiffness and increased viscoelasticity resulting from reduced tissue connectivity—and microglial...
- The National Institute on Aging awarded the Regents of the University of Michigan $218,410 on September 16, 2025, under the Aging Research program (CFDA 93.866) to investigate the link between sleep disturbances and age-related memory loss. The award is classified as a Project Grant. The research examines how sleep deprivation alters the activity and connectivity of somatostatin-expressing inhibitory interneurons in the hippocampus, shifting the brain's excitatory/inhibitory balance and...
- The National Institute on Aging awarded the University of California, San Diego $182,173 on March 1, 2026, under the Aging Research program (CFDA 93.866) to investigate how noradrenergic modulation during non-rapid eye movement sleep relates to memory consolidation and to test whether precise timing of cortical slow oscillations, thalamic spindles, and hippocampal sharp wave-ripples orchestrates memory transfer from hippocampus to cortical long-term memory. The research aims to understand how...
- The National Institute on Aging awarded the Regents of the University of Michigan $654,999 on September 1, 2026, under the Aging Research program (CFDA 93.866) to assess cognitive functioning in the National Monitoring the Future (MTF) Panel Study. The award funds the addition of web-based cognitive measures to the MTF Panel, a nationally representative longitudinal study of high school seniors followed since 1975. The cognitive measures—assessing memory, numeracy, executive functioning, word...
- The National Institute on Aging awarded the Regents of the University of Michigan $116,079 on September 1, 2026, under the Aging Research program (CFDA 93.866) to assess how multilevel life course socioeconomic conditions relate to disparities in Alzheimer's disease and related dementias. The project examines socioeconomic trajectories at both individual and neighborhood levels in relation to cognitive decline, dementia incidence, and brain health indicators including structural magnetic...
- The National Institute on Aging awarded Marquette University $309,000 on May 15, 2026, under the Aging Research program (CFDA 93.866) to conduct longitudinal imaging studies in a preclinical Alzheimer's disease model aimed at identifying early biomarkers of cognitive decline. The project uses in vivo calcium imaging of prefrontal cortical neuronal ensembles and two-photon imaging of amyloid-beta deposits in a transgenic rat model to track changes in genetically defined excitatory and...
- The National Institute on Aging awarded $780,217 to the University of Connecticut Health Center on September 1, 2026, under the Aging Research program (CFDA 93.866) to conduct longitudinal imaging of prefrontal cholinergic dynamics and cognitive flexibility in an Alzheimer's disease model. The research combines chronic two-photon imaging, fluorescent acetylcholine reporting, in vivo beta-amyloid labeling, and cell-type-specific chemogenetic and optogenetic control to test whether amyloid-beta...
- The National Institute on Aging awarded the Regents of the University of Michigan $758,442 on September 1, 2026, under the Aging Research program (CFDA 93.866) to develop and test two pragmatic interventions aimed at increasing brain donation among older adults at risk for Alzheimer's disease and related dementias. The project, "The Brain Gifting Counseling Program: A Novel Peer-Professional Intervention to Enhance Brain Donation Among Older Adults at Risk for Alzheimer's Disease and...
- The National Institute on Aging awarded the University of California Irvine $221,883 on September 1, 2026, under the Aging Research program (CFDA 93.866) to investigate the role of sleep in protecting spatial memory from age-related decline. The project will conduct a single experiment using an ecologically valid ambulatory virtual environment to determine the impact of sleep on spatial memory in cognitively healthy, aged adults and evaluate a potential sleep intervention targeting memory...
- The National Institute on Aging, a component of the Department of Health and Human Services National Institutes of Health, awarded the University of Wisconsin System Office of Sponsored Programs (operating as University of Wisconsin–Milwaukee) $642,805 under the Aging Research program (CFDA 93.866) on January 15, 2026. The award funds three experiments investigating how older age affects memory integration—the ability to generalize across experiences, make inferences, and accumulate knowledge....
The National Institute on Aging awarded Regents of the University of Michigan $131,760 on August 1, 2026, under the Aging Research program (CFDA 93.866) to support research on hippocampal-prefrontal interactions underlying trace memory in aging and a rodent model of Alzheimer's disease. The investigator will perform simultaneous electrophysiological recordings in the hippocampus and calcium imaging recordings in the prefrontal cortex of freely moving rats as they perform a trace conditioning task, tracking the emergence of task-related cortical neuron responses across all stages of learning. The research combines in vivo imaging and electrophysiology with optogenetic neural circuit manipulations following learning to test whether sharp wave ripples—coordinated bursts of hippocampal activity that reverberate through the cortex—support memory trace fear consolidation. The work addresses deficits in memory consolidation and aberrant neural activity that emerge during aging and dementia, with particular focus on how disruption of sharp wave ripples impairs long-term memory retention and how these mechanisms are altered in Alzheimer's disease models. Performance occurs in Michigan. The project period runs from August 1, 2026, through April 30, 2031.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $131.8k | 7/30/26 |