Project Grant R01AG099626
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded a $619,099 Project Grant to the University of California, Irvine under the Aging Research program (CFDA 93.866) effective February 1, 2026 through January 31, 2031. This five-year research initiative addresses a critical knowledge gap by investigating longitudinal relationships between Alzheimer's Disease (AD) pathophysiology, local sleep expression, and sleep-dependent memory across preclinical disease stages. The...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded University of California, San Diego $3,138,871 under the Aging Research program (CFDA 93.866) to conduct a comprehensive four-year research project examining human neuropeptide transmitter systems in Alzheimer's disease (AD) pathogenesis. The project, initiated September 15, 2025 and concluding August 31, 2029, will deliver scientific research services focused on defining the complete repertoire of human brain...
- Federal Grant Award Summary The Salk Institute for Biological Studies received a $785,348 Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), awarded August 15, 2025, with completion targeted for July 31, 2027. This research initiative investigates the mechanisms through which chronic sleep disruption (CSD) functions as a biological stressor affecting healthspan and lifespan, with particular attention to how CSD may interact with established...
- This federal Project Grant award of $442,938, provided by the National Institute on Aging (CFDA 93.866 Aging Research), supports research at the University of California, San Francisco (UCSF) to investigate the relationship between sleep, memory, and aging. The key objectives are to: 1) characterize how aging affects sleep patterns required for memory consolidation and synaptic plasticity during long-term memory formation; and 2) determine how upregulating the unfolded protein response can...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded a $3.22 million Project Grant under the Aging Research program (CFDA 93.866) to the University of California, Irvine on September 15, 2025, for research investigating the role of the retrosplenial cortex (RSC) in Alzheimer's disease (AD) pathogenesis. The project, which extends through August 31, 2029, will deliver scientific research products including characterization of neuronal hyperexcitability mechanisms in...
- Federal Project Grant Award Summary The University of Michigan's Regents received a $107,097 Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), awarded September 16, 2025, with completion targeted for June 30, 2027. The award funds research investigating the relationship between sleep disturbances and memory loss in aging populations, addressing a significant public health concern affecting older adults' independence and quality of life....
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded The Washington University $578,856 on February 15, 2026, under the Aging Research program (CFDA 93.866) to conduct a five-year investigation into the relationship between sleep and neurodegenerative disease. The research project, titled "Sleep Reinforces Homeostatic Set-Points in Neural Activity and Mitigates Neurodegenerative Disease," will deliver scientific findings and methodological advances in...
- Federal Project Grant Award Summary The National Institute on Aging awarded a $749,108 Project Grant to the University of California, Irvine on May 15, 2025, under the Aging Research program (CFDA 93.866) to conduct research examining the relationship between memory failures and decision-making impairment in older adults through May 2030. The project delivers integrated computational and neuroscientific research services designed to understand how different types of memory—including item memory,...
- Federal Project Grant Award Summary Washington State University received a $420,750 Project Grant award from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), effective August 5, 2025 through July 31, 2027. The award funds a comprehensive research investigation examining the reciprocal interactions between cognitive performance, beta-amyloid (Aβ) aggregation, transcriptional processing, and sleep disruption in an Alzheimer's disease model. The research employs...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded a Project Grant of $127,224 to the University of California, San Diego (UCSD) on October 24, 2025, under the Aging Research program (CFDA 93.866) to support scientific investigation into the mechanisms by which s-nitrosylated phospholipase D3 (SNO-PLD3) contributes to Alzheimer's disease (AD) pathophysiology. The research project, with a completion date of August 31, 2028, seeks to elucidate the mechanistic and...
The National Institute on Aging (NIA) awarded UC San Diego a Project Grant totaling $182,173.00 (awarded March 1, 2026, with completion targeted for February 28, 2031) under the Aging Research program (CFDA 93.866). This research grant supports scientific investigation into the noradrenergic modulation of sleep and its relationship to memory consolidation. The primary deliverables include the development of computational models examining how the locus coeruleus—a brain region that releases norepinephrine—orchestrates the coupling between cortical slow oscillations, thalamic spindles, and hippocampal sharp wave-ripples during non-rapid eye movement (NREM) sleep. These models will be tested and refined through multi-site electrophysiological recordings, circuit-selective optogenetic stimulation, and behavioral assessments in rats, with the ultimate goal of understanding how sleep-dependent memory consolidation processes may be altered in normal aging and Alzheimer's disease. The research addresses fundamental questions about how dynamic brain interactions facilitate the transfer of information from the hippocampus to cortical long-term memory during sleep, and how neuromodulatory systems influence these processes. By combining advanced experimental neuroscience techniques with computational modeling, this project will contribute to the National Institute on Aging's broader mission of understanding aging-related cognitive decline and developing potential interventions for neurodegenerative diseases affecting older adults.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $182.2k | 2/20/26 |