Project Grant R01AG103038
- The National Institute on Aging awarded the Regents of the University of Michigan $284,108 on January 1, 2026, under the Aging Research program (CFDA 93.866) to investigate how mechanical changes in the aging brain affect microglial function and Alzheimer's disease progression. The project explores the relationship between age-related mechanical alterations in brain tissue—specifically decreased stiffness and increased viscoelasticity resulting from reduced tissue connectivity—and microglial...
- The National Institute on Aging awarded the Regents of the University of Michigan $116,079 on September 1, 2026, under the Aging Research program (CFDA 93.866) to assess how multilevel life course socioeconomic conditions relate to disparities in Alzheimer's disease and related dementias. The project examines socioeconomic trajectories at both individual and neighborhood levels in relation to cognitive decline, dementia incidence, and brain health indicators including structural magnetic...
- The National Institute on Aging awarded the Regents of the University of Michigan $654,999 on September 1, 2026, under the Aging Research program (CFDA 93.866) to assess cognitive functioning in the National Monitoring the Future (MTF) Panel Study. The award funds the addition of web-based cognitive measures to the MTF Panel, a nationally representative longitudinal study of high school seniors followed since 1975. The cognitive measures—assessing memory, numeracy, executive functioning, word...
- The National Institute on Aging awarded the Regents of the University of Michigan $655,198 on March 1, 2026, under the Aging Research program (CFDA 93.866) to develop and validate bispecific antibodies capable of delivering antisense oligonucleotides across the blood-brain barrier and into microglia following intravenous administration. The research targets non-invasive modulation of microglia gene expression, with the goal of enabling selective in vivo gene silencing in brain microglia...
- The National Institute on Aging awarded Michigan State University (doing business as Henry Ford Health+Michigan State University Health Sciences) $624,029 on September 1, 2026, for research into dimensional complexity as a biomarker for cognitive resilience in aging and dementia under the Aging Research program (CFDA 93.866). The project will develop and clinically validate dimensional complexity (DC), a novel resting-state fMRI biomarker that quantifies dynamic brain activity organization, to...
- The National Institute on Aging awarded Regents of the University of Michigan $131,760 on August 1, 2026, under the Aging Research program (CFDA 93.866) to support research on hippocampal-prefrontal interactions underlying trace memory in aging and a rodent model of Alzheimer's disease. The investigator will perform simultaneous electrophysiological recordings in the hippocampus and calcium imaging recordings in the prefrontal cortex of freely moving rats as they perform a trace conditioning...
- The National Institute on Aging awarded Michigan State University (doing business as Henry Ford Health+Michigan State University Health Sciences) $314,000 on April 1, 2026, under the Aging Research program (CFDA 93.866) to optimize and validate detection and modeling of the vascular and glymphatic systems in cerebral waste clearance using superparamagnetic iron oxide-enhanced susceptibility weighted imaging (SPIO-SWI), and to investigate cerebral waste clearance changes during Alzheimer's...
- The National Institute on Aging, part of the Department of Health and Human Services, awarded $298,419 to the Regents of the University of Michigan on February 1, 2026, under the Aging Research program (CFDA 93.866, Assistance Listing Project Grant R01AG097771). The recipient will develop advanced statistical and computational methods for analyzing immune cell data to enhance understanding of the immune system's role in aging and age-related diseases. The project addresses analytical...
- The National Institute on Aging awarded the Regents of the University of Michigan $126,969 on September 1, 2026, under the Aging Research program (CFDA 93.866) to conduct research determining the unique molecular and cellular features of limbic-predominant age-related TDP-43 encephalopathy (LATE). The recipient will compare the intrinsic properties of TDP-43 aggregates in FTLD-TDP (frontotemporal lobar degeneration with TDP-43 deposition) and LATE through high-resolution cryo-electron microscopy...
- The National Institute on Aging awarded the Regents of the University of Michigan $1,732,842 on March 1, 2026, under the Aging Research program (CFDA 93.866) to conduct a comprehensive genetic analysis of cognitive outcomes under caloric restriction using Diversity Outbred mouse panels. The research identifies genetic factors and mechanisms underlying variation in cognitive performance following adult-onset caloric restriction in aging mice, with particular focus on cognitive resilience. The...
The National Institute on Aging awarded the Regents of the University of Michigan $758,442 on September 1, 2026, under the Aging Research program (CFDA 93.866) to develop and test two pragmatic interventions aimed at increasing brain donation among older adults at risk for Alzheimer's disease and related dementias. The project, "The Brain Gifting Counseling Program: A Novel Peer-Professional Intervention to Enhance Brain Donation Among Older Adults at Risk for Alzheimer's Disease and Related Dementias," will deliver a brain gifting education toolkit and a peer-professional facilitated counseling program grounded in the transtheoretical model of health behavior change. The interventions target documented barriers to brain donation, including poor awareness, inadequate family integration, participant retention challenges, and research mistrust. Using a randomized controlled trial design, the University of Michigan will test these interventions with participants and families from the Michigan Alzheimer's Disease Research Center research registry and longitudinal cohort, leveraging interdisciplinary expertise across the Michigan Alzheimer's Disease Research Center and the University of Michigan Brain Bank. Performance occurs in Ann Arbor, Michigan, with a period of performance from September 1, 2026, through August 31, 2031.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $758.4k | 9/1/26 |