This $1,269,993 federal Project Grant award from the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) supports research to understand the molecular basis of how plant cells establish the division plane during cell division. The project aims to dissect the function of cytoskeletal motor assemblies at the cortical division site and determine how they connect to molecules in the phragmoplast, the structure that forms the new cell wall during cytokinesis. Researchers at...
The National Science Foundation awarded New York University a $120,000 Project Grant under the Mathematical and Physical Sciences federal grant program (CFDA 47.049) to develop a mathematical model of mitosis. The award period is from June 15, 2022 to May 31, 2026. Under the award, NYU will build on previous work modeling cell division to create a more realistic simulation of closed mitosis. Researchers will extend their model to include a deformable elastic nuclear envelope integrating the...
This National Science Foundation Project Grant of $673,524 supports research at North Carolina State University to develop a mathematical model of mitosis through the Biological Sciences program (CFDA 47.074). The model will simulate chromosome segregation and nuclear envelope shape change coordination in fission yeast mitosis. Researchers will extend an existing mitosis model to include a deformable elastic nuclear envelope integrating the spindle, chromosomes, and nuclear envelope. They will...
This National Science Foundation award provides $1,656,474 to the University of Colorado Boulder through May 2026 to develop mathematical models of mitosis under the Biological Sciences grant program (CFDA 47.074). The university will build on previous work modeling chromosome segregation during cell division to create a new model integrating deformable nuclear envelope dynamics. Researchers aim to identify how forces within the nuclear envelope drive successful chromosome separation during...
This three-year, $719,144 project grant from the National Science Foundation's Mathematical and Physical Sciences program (CFDA 47.049) supports research at Rensselaer Polytechnic Institute to develop a mesoscale kinetic theory framework for early mitotic spindle organization. The framework will use statistical summaries and parameterization through in vitro experiments to model crosslinker-mediated interactions between microtubules during cell division. Researchers will construct a reduced...
This federal Project Grant award of $946,895 from the National Science Foundation's (NSF) Division of Molecular and Cellular Biosciences (CFDA 47.074 Biological Sciences) will fund research to advance the understanding of protein phosphorylation and its role in coordinating cell division. The project aims to identify new enzymes that carry out phosphorylation and the substrate proteins they modify to ensure proper cell division. Researchers will employ computational, biochemical, proteomic,...
This Project Grant award, valued at $257,591, was provided by the National Science Foundation's (NSF) Division of Mathematical Sciences under the Mathematical and Physical Sciences (CFDA 47.049) federal grant program. The award supports a collaborative research project between the University of California-Riverside and the University of Notre Dame to develop data-driven, multi-scale mathematical and computational models for investigating the critical signaling pathways and biophysical mechanisms...
This three-year $484,222 project grant from the National Science Foundation's Mathematical and Physical Sciences program (CFDA 47.049) supports collaborative research at the University of Colorado Boulder to develop a mesoscale kinetic theory framework for early mitotic spindle organization. The research team will combine biophysical experiments, computational modeling, and statistical analysis to build understanding of how spindle formation is affected by interactions between diverse protein...
This National Science Foundation (NSF) Division of Molecular and Cellular Biosciences Project Grant, titled "TUNING MICROTUBULE-ACTIN CROSSTALK TO CONTROL MITOTIC FIDELITY", will provide $488,281 in funding to the University of Washington from August 1, 2023 to July 31, 2026. The project aims to describe a biological phenomenon where small changes in microtubule assembly temporarily promote the delivery of molecules that interfere with the mitotic spindle's ability to properly position...
This $826,720 Project Grant award from the National Science Foundation's Biological Sciences program (CFDA 47.074) supports research at the University of California, Riverside to investigate the mechanisms that regulate plant cell division positioning. The key objectives are to: Assess whether two proteins, TANGLED1 (TAN1) and AUXIN INDUCED IN ROOT CULTURES9 (AIR9), physically interact to mediate division plane positioning in the model plant Arabidopsis thaliana. Characterize genetic...
This $661,433 Project Grant was awarded by the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) to the University of Missouri System on October 1, 2024. The project aims to examine the molecular mechanisms that orient cell divisions within tissues across multiple cell and tissue types in the model organism Drosophila melanogaster. The research leverages advanced microscopy and CRISPR genome editing techniques to better understand how regulated cell division orientation contributes to tissue shape, cell type diversity, and other key biological processes.
As part of this project, the University of Rochester is receiving a $109,619 sub-award to support the dissertation research of a PhD student, Alikhan, who is developing a mathematical model for spindle orientation that will be tested and refined through experimental work in the lab. The sub-award reflects the collaborative nature of the project, which also involves researchers from the University of North Carolina and University of Manchester.