This Project Grant award, valued at $257,591, was provided by the National Science Foundation's (NSF) Division of Mathematical Sciences under the Mathematical and Physical Sciences (CFDA 47.049) federal grant program. The award supports a collaborative research project between the University of California-Riverside and the University of Notre Dame to develop data-driven, multi-scale mathematical and computational models for investigating the critical signaling pathways and biophysical mechanisms that regulate organ development and epithelial cell function, with a focus on the fruit fly wing disc as a model system. The research aims to provide mechanistic insights into how hormonal signaling, morphogen-driven pattern formation, and cytoskeletal regulators synergistically impact epithelial organ architecture. Key innovations include simulation acceleration via neural networks and a data-driven, machine learning-enabled pipeline to calibrate candidate models and optimize experimental design. The project, which runs from September 1, 2024 to August 31, 2027, also includes efforts to increase the diversity of students pursuing graduate education in mathematical biology, applied mathematics, and bioengineering.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $257.6k | 8/23/24 |