Project Grant 2133276
- This National Science Foundation award provides $1,656,474 to the University of Colorado Boulder through May 2026 to develop mathematical models of mitosis under the Biological Sciences grant program (CFDA 47.074). The university will build on previous work modeling chromosome segregation during cell division to create a new model integrating deformable nuclear envelope dynamics. Researchers aim to identify how forces within the nuclear envelope drive successful chromosome separation during...
- The National Science Foundation awarded New York University a $120,000 Project Grant under the Mathematical and Physical Sciences federal grant program (CFDA 47.049) to develop a mathematical model of mitosis. The award period is from June 15, 2022 to May 31, 2026. Under the award, NYU will build on previous work modeling cell division to create a more realistic simulation of closed mitosis. Researchers will extend their model to include a deformable elastic nuclear envelope integrating the...
- This three-year, $719,144 project grant from the National Science Foundation's Mathematical and Physical Sciences program (CFDA 47.049) supports research at Rensselaer Polytechnic Institute to develop a mesoscale kinetic theory framework for early mitotic spindle organization. The framework will use statistical summaries and parameterization through in vitro experiments to model crosslinker-mediated interactions between microtubules during cell division. Researchers will construct a reduced...
- The National Science Foundation awarded a $1,715,342 project grant to The Regents of the University of California, San Francisco under the Biological Sciences program (CFDA 47.074) to elucidate the mechanisms that regulate nuclear size in cells. Over three years from August 2022 through July 2025, the researchers will develop a quantitative model proposing that nuclear size is specified by physical factors such as osmotic pressure and membrane tension. They will test this osmotic model of...
- This $1.2 million National Science Foundation project grant, awarded under the Biological Sciences program (CFDA 47.074), will fund research at the University of North Carolina at Chapel Hill from March 2023 through February 2027 toward developing a revised model of the cell cycle that captures reversible and irreversible cell cycle arrest. The principal investigator will define the molecular mechanisms governing the transition between reversible quiescence and irreversible senescence, as well...
- This $1,269,993 federal Project Grant award from the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) supports research to understand the molecular basis of how plant cells establish the division plane during cell division. The project aims to dissect the function of cytoskeletal motor assemblies at the cortical division site and determine how they connect to molecules in the phragmoplast, the structure that forms the new cell wall during cytokinesis. Researchers at...
- This Project Grant award from the National Science Foundation (NSF) Engineering program (CFDA 47.041) provides $393,371 to the Texas A&M Engineering Experiment Station (Tees) to conduct research on the mechanics of the nuclear envelope (NE) - the physical barrier between the cytoplasm and the nucleus in eukaryotic cells. The overarching goals are to: 1) discover the link between NE structure and its mechanical properties, and 2) identify principles for designing new biologically-inspired...
- This three-year $484,222 project grant from the National Science Foundation's Mathematical and Physical Sciences program (CFDA 47.049) supports collaborative research at the University of Colorado Boulder to develop a mesoscale kinetic theory framework for early mitotic spindle organization. The research team will combine biophysical experiments, computational modeling, and statistical analysis to build understanding of how spindle formation is affected by interactions between diverse protein...
- This Project Grant award from the National Science Foundation's (NSF) Mathematical and Physical Sciences Federal Grant Program (CFDA 47.049) provides $380,000 to Northeastern University to develop a new generation of computational models for studying eukaryotic cell motility. The research aims to better understand how cells move through complex tissues, which is critical for both healthy developmental processes and the spread of cancer. The project will involve a collaborative effort between...
- This federal Project Grant award of $454,367.00 was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) to North Carolina State University. The award supports research to determine the mechanisms that govern force production during cytokinesis, the process of cell division. The research aims to reveal how the contractile ring, composed of actin filaments and myosin, generates the forces needed to...
This National Science Foundation Project Grant of $673,524 supports research at North Carolina State University to develop a mathematical model of mitosis through the Biological Sciences program (CFDA 47.074). The model will simulate chromosome segregation and nuclear envelope shape change coordination in fission yeast mitosis. Researchers will extend an existing mitosis model to include a deformable elastic nuclear envelope integrating the spindle, chromosomes, and nuclear envelope. They will identify how nuclear envelope forces and deformation drive successful chromosome segregation in closed mitosis by modeling and measuring envelope shape, spindle dynamics, and chromosome movement with nuclear envelope perturbations. New algorithms and software will also be developed for membrane-cytoskeleton interaction simulation, an area currently difficult to model. The award period is from June 15, 2022 through May 31, 2026.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $336.8k | 6/9/22 |