This National Science Foundation award provides $1,656,474 to the University of Colorado Boulder through May 2026 to develop mathematical models of mitosis under the Biological Sciences grant program (CFDA 47.074). The university will build on previous work modeling chromosome segregation during cell division to create a new model integrating deformable nuclear envelope dynamics. Researchers aim to identify how forces within the nuclear envelope drive successful chromosome separation during closed mitosis. They will develop algorithms and software to simulate membrane-cytoskeleton interactions, extending existing models to include an elastic nuclear envelope boundary. Findings seek to further understanding of mitosis across life by studying nuclear envelope function. The award also supports interdisciplinary education in biophysics, cell biology, and mathematical modeling through an international online seminar series.
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