This three-year $484,222 project grant from the National Science Foundation's Mathematical and Physical Sciences program (CFDA 47.049) supports collaborative research at the University of Colorado Boulder to develop a mesoscale kinetic theory framework for early mitotic spindle organization. The research team will combine biophysical experiments, computational modeling, and statistical analysis to build understanding of how spindle formation is affected by interactions between diverse protein components. Methodologically, the work aims to evolve a physically interpretable structural theory of early spindle formation through clearly linked stages of increasing complexity. The key novelty is construction of a reduced statistical description treating the spindle and protein concentrations through summaries, parameterized through designed in vitro experiments. This will enable interrogation of physical assumptions regarding how crosslinker behavior scales from microtubule pairs to bundles. Outreach for students is also supported to emphasize collaborative methodologies across mathematics, physics and biology for life sciences problems.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $242.1k | 6/28/22 |