Project Grant RF1AG097660
- The National Institute on Aging awarded Vanderbilt University Medical Center $707,033 on September 1, 2026, under the Aging Research program (CFDA 93.866) to develop and validate novel statistical machine learning approaches that leverage baseline neuroimaging data to increase the statistical power and cost-effectiveness of clinical trials in Alzheimer's disease and late-life depression. The project addresses the challenge of efficiently utilizing rich neuroimaging datasets collected at baseline...
- The National Institute on Aging, part of the Department of Health and Human Services National Institutes of Health, awarded the University of Pittsburgh $2,003,400 on September 15, 2025, under the Aging Research program (CFDA 93.866) to characterize white matter injury in Alzheimer's disease. The research investigates risk factors for and consequences of white matter injury in brain regions affected by Alzheimer's pathology using a novel, spatially precise measurement method called unhealthy...
- The National Institute on Aging awarded the University of Virginia $583,815 on August 15, 2026, under the Aging Research program (CFDA 93.866) to support research into oligodendrocyte lineage dysfunction during aging and Alzheimer's disease. The project aims to understand how myelin loss—a pathology common to both aging and Alzheimer's disease—develops in the central nervous system and to identify therapeutic targets for cognitive impairment. The research focuses on oligodendrocyte precursor...
- The National Institute on Aging awarded Vanderbilt University Medical Center $3,079,819 for a Project Grant (R01AG092663) on January 1, 2026, under the Aging Research program (CFDA 93.866). The award funds research probing mechanistic links between endothelial aging and dementia. The recipient will passage human induced pluripotent stem cells differentiated to endothelial cells (hiPSC-ECs) obtained from healthy adults and individuals with vascular contributions to cognitive impairment and...
- The National Institute on Aging, part of the Department of Health and Human Services, awarded $435,875 to Vanderbilt University on May 15, 2026, under the Aging Research program (CFDA 93.866) to define characteristics of a resilient organelle interactome during aging. The research applies advanced 3D electron microscopy and artificial intelligence-based image analysis to map organelle interactions in Caenorhabditis elegans model organisms across the aging process. The work compares age-dependent...
- The National Institute on Aging awarded Texas A&M University $640,059 on September 1, 2026, under the Aging Research program (CFDA 93.866) to investigate cerebellar changes in aging and cognitive decline through longitudinal neuroimaging and functional analysis. The project examines how cerebellar structure, white matter circuits, and task-based functional activation change over time in older adults, with particular focus on individuals experiencing subjective cognitive decline—self-reported...
- The National Institute on Aging awarded Vanderbilt University $105,627 under the Aging Research program (CFDA 93.866) on August 5, 2026, to support an F30 predoctoral fellowship investigating how somatic mutations in hematopoietic stem cells contribute to aging-related diseases through clonal expansion of mutated blood cells. The research focuses on mosaic chromosomal alterations (MCAs), large-scale mutations linked to lymphoid malignancies and infection susceptibility. Aim 1 examines the...
- The National Institute on Aging awarded New York University $466,125 under the Aging Research program (CFDA 93.866) on January 15, 2026, to develop innovative magnetic resonance imaging analysis tools for identifying microstructural biomarkers of skeletal muscle health across the lifespan. The project, titled "(Micro)structural Biomarkers of Skeletal Muscle Health Across the Lifespan," addresses sarcopenia—a leading cause of disability and mortality in aging populations—by creating...
- The National Institute on Aging awarded the University of Virginia $2.877 million on July 1, 2026, under the Aging Research program (CFDA 93.866) to investigate microglia's role in neurovascular coupling and hypertensive cerebral small vessel disease. The project will test the hypothesis that microglial dysregulation of cerebral blood flow leads to hypertensive vascular dementia and endothelial rarefaction as common pathological events with Alzheimer's disease. Aim 1 will employ laser speckle...
- The National Institute on Aging awarded New York University $6.203 million on September 15, 2025, under the Aging Research program (CFDA 93.866) to examine peripheral immune markers and vascular dysfunction as contributors to cognitive decline and Alzheimer's disease. The research integrates circulating biomarkers—platelet aggregation, neutrophil activity, and proteomic data—with advanced imaging to assess associations between vascular and immune dysfunction and cerebrovascular burden, amyloid...
The National Institute on Aging awarded Vanderbilt University Medical Center $2,129,341 on August 15, 2026, under the Aging Research program (CFDA 93.866) to conduct multiscale functional assessment of white matter across the life span. The research investigates blood oxygenation level-dependent (BOLD) signals in white matter using functional magnetic resonance imaging (fMRI) to characterize how white matter function evolves across developmental, adult, and aging stages. The project quantifies white matter engagement—the degree to which local white matter activity predicts distributed cortical dynamics—and characterizes tract-type-specific and depth-dependent BOLD spectra and hemodynamic response profiles to identify how myelination, vascular architecture, and neurovascular efficiency shape intrinsic white matter signal dynamics. The work also examines white matter hyperintensities and lesion-prone regions to determine how disruptions in microstructure and neurovascular coupling affect local function and tissue vulnerability across the lifespan. The award runs through July 31, 2030, with place of performance in Forest Hills, Tennessee. This is a Project Grant, the standard assistance type for investigator-initiated research under the National Institute on Aging's mission to support biomedical and behavioral research directed toward greater understanding of aging processes and age-related diseases.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $340.7k | 8/17/26 | ||
| Not listed | $1.8m | 8/13/26 |